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Generic Name: pimavanserin (PIM a VAN ser in )
Brand Names: Nuplazid

Medically reviewed on September 19, 2016

What is Nuplazid?

Nuplazid (pimavanserin) is an antipsychotic medicine that works by changing the actions of chemicals in the brain.

Nuplazid is used to treat hallucinations and delusions caused by psychosis that is related to Parkinson's disease.

Nuplazid may also be used for purposes not listed in this medication guide.

Important information

Nuplazid is not approved for use in psychotic conditions related to dementia. Pimavanserin may increase the risk of death in older adults with dementia-related conditions.

Before taking this medicine

Nuplazid is not approved for use in psychotic conditions related to dementia and not to Parkinson's disease. Nuplazid may increase the risk of death in older adults with dementia-related conditions.

You should not use Nuplazid if you are allergic to pimavanserin.

Nuplazid can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all the medicines you use.

To make sure Nuplazid is safe for you, tell your doctor if you have:

  • a heart rhythm disorder;

  • personal or family history of long QT syndrome;

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

  • liver disease; or

  • kidney disease.

It is not known whether Nuplazid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether pimavanserin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby while taking Nuplazid.

How should I take Nuplazid?

Nuplazid is usually taken once daily. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take Nuplazid with or without food.

Your Nuplazid dose may need to be adjusted up or down if you use certain other medications, especially an antibiotic or antifungal medicine, heart or blood pressure medicine, seizure medication, or drugs to treat HIV, hepatitis, or tuberculosis. It is very important to tell your doctor if you start or stop using any other medications.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Store at room temperature away from moisture and heat.

Nuplazid dosing information

Usual Adult Dose of Nuplazid for Psychosis:

Recommended dose: 34 mg (as two 17 mg tablets) orally once a day

-This drug does not require titration.

Use: Treatment of hallucinations and delusions associated with Parkinson's disease psychosis

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause nausea and vomiting.

What should I avoid while taking Nuplazid?

Avoid drinking alcohol. Dangerous side effects could occur.

Nuplazid side effects

Get emergency medical help if you have signs of an allergic reaction to Nuplazid: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or pounding heartbeats;

  • headache with chest pain; or

  • severe dizziness.

Common Nuplazid side effects may include:

  • confusion; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Nuplazid?

Taking Nuplazid with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with pimavanserin, and your Nuplazid dose may need to be adjusted if you also use other medications. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • donepezil;

  • droperidol;

  • hydrocodone, methadone;

  • ondansetron;

  • St. John's wort;

  • an antidepressant - citalopram, escitalopram, nefazodone;

  • an antibiotic - azithromycin, ciprofloxacin, clarithromycin, erythromycin, gatifloxacin, levofloxacin, moxifloxacin, pentamidine, telithromycin;

  • antifungal medicine - fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole;

  • anti-malaria medication - chloroquine, halofantrine;

  • antiviral medicine to treat hepatitis or HIV/AIDS - atazanavir, boceprevir, cobicistat, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir;

  • cancer medicine - arsenic trioxide, imatinib, oxaliplatin vandetanib;

  • heart or blood pressure medicine - nicardipine, quinidine;

  • heart rhythm medicine - amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, procainamide, quinidine, sotalol;

  • medicine to treat a psychiatric disorder - asenapine, chlorpromazine, haloperidol, pimozide, thioridazine, ziprasidone;

  • seizure medicine - carbamazepine, phenytoin; or

  • tuberculosis medicine - isoniazid, rifampin.

This list is not complete and many other drugs can interact with pimavanserin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Nuplazid only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.