Nuplazid Side Effects

Generic name: pimavanserin

Medically reviewed by Drugs.com. Last updated on Dec 1, 2023.

Note: This document provides detailed information about Nuplazid Side Effects associated with pimavanserin. Some dosage forms listed on this page may not apply specifically to the brand name Nuplazid.

Applies to pimavanserin: oral capsule, oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Increased Mortality in Elder Patients With Dementia Related Psychosis. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

Pimavanserin is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.

Common side effects of Nuplazid

Some side effects of pimavanserin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• bloating or swelling of the face, arms, hands, lower legs, or feet
• confusion
• constipation
• nausea
• rapid weight gain
• unusual weight gain or loss

Less common

• change in walking and balance
• clumsiness or unsteadiness
• difficulty having a bowel movement

Incidence not known

• sleepiness or unusual drowsiness

Serious side effects of Nuplazid

Along with its needed effects, pimavanserin (the active ingredient contained in Nuplazid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pimavanserin:

Incidence not known

• chest pain, discomfort, or tightness
• fainting
• irregular or slow heart rate
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
• trouble breathing

For healthcare professionals

Applies to pimavanserin: oral capsule, oral tablet.

General

The most commonly reported side effects are peripheral edema and confusional state.^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, nausea
• Postmarketing reports: Tongue swelling^[Ref]

Psychiatric

• Common (1% to 10%): Confusional state, hallucinations^[Ref]

Hallucinations included visual, auditory, tactile, and somatic hallucinations.^[Ref]

Cardiovascular

• Common (1% to 10%): Peripheral edema
• Frequency not reported: QT interval prolongation^[Ref]

Nervous system

• Common (1% to 10%): Gait disturbance^[Ref]

Other

• Common (1% to 10%): Fatigue^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Dermatologic

• Postmarketing reports: Circumoral edema, rash, urticaria^[Ref]

Hypersensitivity

• Postmarketing reports: Angioedema^[Ref]

Respiratory

• Postmarketing reports: Dyspnea, throat tightness^[Ref]

Frequently asked questions

• Does Nuplazid treat Parkinson's disease?

Further information

Nuplazid side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer