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Nuplazid Side Effects

Generic Name: pimavanserin

Note: This document contains side effect information about pimavanserin. Some of the dosage forms listed on this page may not apply to the brand name Nuplazid.

In Summary

More frequent side effects include: peripheral edema. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pimavanserin: oral tablet

Along with its needed effects, pimavanserin (the active ingredient contained in Nuplazid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pimavanserin:

Incidence not known

Some side effects of pimavanserin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • confusion
  • nausea
  • rapid weight gain
  • unusual weight gain or loss
Less common
  • Change in walking and balance
  • clumsiness or unsteadiness
  • difficulty having a bowel movement (stool)

For Healthcare Professionals

Applies to pimavanserin: oral tablet


The most commonly reported side effects are peripheral edema and confusional state.[Ref]


Common (1% to 10%): Constipation, nausea
Postmarketing reports: Tongue swelling[Ref]


Common (1% to 10%): Confusional state, hallucinations[Ref]

Hallucinations included visual, auditory, tactile, and somatic hallucinations.[Ref]


Common (1% to 10%): Peripheral edema
Frequency not reported: QT interval prolongation[Ref]

Nervous system

Common (1% to 10%): Gait disturbance[Ref]


Common (1% to 10%): Fatigue[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Postmarketing reports: Circumoral edema, rash, urticaria[Ref]


Postmarketing reports: Angioedema[Ref]


Postmarketing reports: Dyspnea, throat tightness[Ref]


1. "Product Information. Nuplazid (pimavanserin)." Accelis Pharma, East Windsor, NJ.

Some side effects of Nuplazid may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.