Nuplazid Side Effects
Generic name: pimavanserin
Medically reviewed by Drugs.com. Last updated on Aug 2, 2024.
Note: This document provides detailed information about Nuplazid Side Effects associated with pimavanserin. Some dosage forms listed on this page may not apply specifically to the brand name Nuplazid.
Applies to pimavanserin: oral capsule, oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
Increased Mortality in Elder Patients With Dementia Related Psychosis. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Pimavanserin is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.
Precautions
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.
Contact your doctor right away if you feel dizzy or faint, or have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Common side effects of Nuplazid
Some side effects of pimavanserin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- bloating or swelling of the face, arms, hands, lower legs, or feet
- confusion
- constipation
- nausea
- rapid weight gain
- unusual weight gain or loss
Less common side effects
- change in walking and balance
- clumsiness or unsteadiness
- difficulty having a bowel movement
Incidence not known
- sleepiness or unusual drowsiness
Serious side effects of Nuplazid
Along with its needed effects, pimavanserin (the active ingredient contained in Nuplazid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking pimavanserin:
Incidence not known
- chest pain, discomfort, or tightness
- fainting
- irregular or slow heart rate
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- trouble breathing
For healthcare professionals
Applies to pimavanserin: oral capsule, oral tablet.
General adverse events
The most commonly reported side effects are peripheral edema and confusional state.[Ref]
Gastrointestinal
- Common (1% to 10%): Constipation, nausea
- Postmarketing reports: Tongue swelling[Ref]
Psychiatric
- Common (1% to 10%): Confusional state, hallucinations[Ref]
Hallucinations included visual, auditory, tactile, and somatic hallucinations.[Ref]
Cardiovascular
- Common (1% to 10%): Peripheral edema
- Frequency not reported: QT interval prolongation[Ref]
Nervous system
- Common (1% to 10%): Gait disturbance[Ref]
Other
Genitourinary
- Common (1% to 10%): Urinary tract infection[Ref]
Dermatologic
Hypersensitivity
- Postmarketing reports: Angioedema[Ref]
Respiratory
See also:
Abilify
Abilify is an antipsychotic medicine used to treat the symptoms of schizophrenia and bipolar ...
Abilify Asimtufii
Abilify Asimtufii is used for the treatment of schizophrenia and bipolar I disorder, Abilify ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Abilify Maintena
Abilify Maintena (aripiprazole) is an atypical antipsychotic used to treat schizophrenia and ...
Abilify MyCite
Abilify MyCite is used for bipolar disorder, depression, schizophrenia
Aristada
Aristada (aripiprazole) is an antipsychotic medication. It works by changing the actions of ...
Caplyta
Caplyta is used to treat schizophrenia or depression associated with bipolar disorder. It is taken ...
Clozaril
Clozaril is used to treat severe schizophrenia symptoms in people who have not responded to other ...
References
1. (2016) "Product Information. Nuplazid (pimavanserin)." Accelis Pharma
Frequently asked questions
More about Nuplazid (pimavanserin)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (15)
- Drug images
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: atypical antipsychotics
- Breastfeeding
- En español
Patient resources
Professional resources
Related treatment guides
Further information
Nuplazid side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
