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Nuplazid Side Effects

Generic name: pimavanserin

Medically reviewed by Last updated on Dec 2, 2022.

Note: This document contains side effect information about pimavanserin. Some dosage forms listed on this page may not apply to the brand name Nuplazid.


More frequent side effects include: peripheral edema. Continue reading for a comprehensive list of adverse effects.

Applies to pimavanserin: oral capsule, oral tablet.


Oral route (Tablet)

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Pimavanserin is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson's disease psychosis.

Serious side effects of Nuplazid

Along with its needed effects, pimavanserin (the active ingredient contained in Nuplazid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pimavanserin:

Incidence not known

  • Chest pain, discomfort, or tightness
  • fainting
  • irregular or slow heart rate
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • trouble breathing

Other side effects of Nuplazid

Some side effects of pimavanserin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • confusion
  • nausea
  • rapid weight gain
  • unusual weight gain or loss

Less common

  • Change in walking and balance
  • clumsiness or unsteadiness
  • difficulty having a bowel movement

Incidence not known

  • Sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to pimavanserin: oral capsule, oral tablet.


The most commonly reported side effects are peripheral edema and confusional state.[Ref]


Common (1% to 10%): Constipation, nausea

Postmarketing reports: Tongue swelling[Ref]


Hallucinations included visual, auditory, tactile, and somatic hallucinations.[Ref]

Common (1% to 10%): Confusional state, hallucinations[Ref]


Common (1% to 10%): Peripheral edema

Frequency not reported: QT interval prolongation[Ref]

Nervous system

Common (1% to 10%): Gait disturbance[Ref]


Common (1% to 10%): Fatigue[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Postmarketing reports: Circumoral edema, rash, urticaria[Ref]


Postmarketing reports: Angioedema[Ref]


Postmarketing reports: Dyspnea, throat tightness[Ref]

Frequently asked questions


1. "Product Information. Nuplazid (pimavanserin)." Accelis Pharma (2016):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.