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Phenergan VC Side Effects

Generic Name: phenylephrine / promethazine

Note: This page contains side effects data for the generic drug phenylephrine / promethazine. It is possible that some of the dosage forms included below may not apply to the brand name Phenergan VC.

For the Consumer

Applies to phenylephrine / promethazine: oral syrup

Get emergency medical help if you have any of these signs of an allergic reaction while taking phenylephrine / promethazine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • seizure (convulsions);

  • weak or shallow breathing;

  • jaundice (yellowing of the skin or eyes);

  • confusion, hallucinations;

  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;

  • uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • dizziness, drowsiness;

  • dry mouth, nose, or throat;

  • blurred vision; or

  • constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to phenylephrine / promethazine: oral syrup


Cardiovascular side effects have included increased or decreased blood pressure.[Ref]

Nervous system

Nervous system side effects have included sedation, sleepiness, dizziness, confusion, disorientation, restlessness, anxiety, nervousness, tremor, weakness, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion.[Ref]


Ocular side effects have included blurred vision.[Ref]


Gastrointestinal side effects have included dry mouth, nausea, and vomiting.[Ref]


Hematologic side effects have included rare cases of leukopenia, thrombocytopenia, and agranulocytosis.[Ref]


Dermatologic side effects have included rash and rarely photosensitivity.[Ref]


Respiratory side effects have included respiratory distress.[Ref]


1. "Product Information. Phenergan VC (phenylephrine-promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

It is possible that some side effects of Phenergan VC may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.