Pepto Diarrhea Control Side Effects
Generic name: loperamide
Medically reviewed by Drugs.com. Last updated on Apr 28, 2021.
Note: This document contains side effect information about loperamide. Some of the dosage forms listed on this page may not apply to the brand name Pepto Diarrhea Control.
For the Consumer
Applies to loperamide: oral capsule, oral capsule liquid filled, oral liquid, oral solution, oral suspension, oral tablet
Oral route (Capsule)
Cases of Torsades de Pointes, cardiac arrest, and death have been reported with the use of a higher than recommended dosages of loperamide hydrochloride. Loperamide hydrochloride is contraindicated in pediatric patients less than 2 years of age. Avoid loperamide hydrochloride dosages higher than recommended in adults and pediatric patients 2 years of age and older due to the risk of serious cardiac adverse reactions.
Side effects requiring immediate medical attention
Along with its needed effects, loperamide (the active ingredient contained in Pepto Diarrhea Control) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking loperamide:
Incidence not known
- Blistering, peeling, loosening of skin
- chest pain or discomfort
- decrease in urine volume
- decrease in frequency of urination
- difficulty in passing urine
- fast, pounding, or irregular heartbeat or pulse
- hives or welts, itching, rash
- irregular or slow heartbeat
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
- no blood pressure or pulse
- painful urination
- red irritated eyes
- redness of the skin
- red skin lesions, often with a purple center
- sores, ulcers, or white spots in the mouth or on the lips
- sore throat
- stopping of heart
- unusual tiredness or weakness
Side effects not requiring immediate medical attention
Some side effects of loperamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Acid or sour stomach
- dryness of mouth
- excess air or gas in the stomach or bowels
- full feeling
- passing gas
- stomach upset
For Healthcare Professionals
Applies to loperamide: compounding powder, oral capsule, oral liquid, oral suspension, oral tablet, oral tablet chewable
Uncommon (0.1% to 1%): Abdominal discomfort, abdominal pain upper, dyspepsia
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Somnolence
Rare (less than 0.1%): Loss of consciousness, stupor, depressed level of consciousness, hypertonia, coordination abnormality
Rare (less than 0.1%): Fatigue
Postmarketing reports: Death, tiredness[Ref]
Postmarketing reports: QT/QTc prolongation, Torsades de Pointes, other ventricular arrhythmias, cardiac arrest[Ref]
Uncommon (0.1% to 1%): Rash
Rare (less than 0.1%): Miosis
More about Pepto Diarrhea Control (loperamide)
Related treatment guides
1. Brown JW "Toxic megacolon associated with loperamide therapy." JAMA 241 (1979): 501-2
2. "Product Information. Loperamide Hydrochloride (loperamide)." Teva Pharmaceuticals USA, North Wales, PA.
3. Walley T, Milson D "Loperamide related toxic megacolon in Clostridium difficile colitis." Postgrad Med J 66 (1990): 582
4. "Product Information. Imodium (loperamide)." Janssen Pharmaceutica, Titusville, NJ.
5. Ericsson CD, Johnson PC "Safety and efficacy of loperamide." Am J Med 88 (1990): s10-4
6. Olm M, Gonzalez FJ, Garcia-Valdecasas JC, Fuster J, Bertran A, Milla J "Necrotising colitis with perforation in diarrhoic patients treated with loperamide." Eur J Clin Pharmacol 40 (1991): 415-6
7. Katz JP, Sturmann KM "Appendicitis associated with loperamide hydrochloride abuse." Ann Pharmacother 27 (1993): 369-70
8. Hill MA, Greason FC "Loperamide dependence." J Clin Psychiatry 53 (1992): 450
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.