Palforzia Side Effects

Generic name: peanut allergen powder

Medically reviewed by Drugs.com. Last updated on May 21, 2023.

Note: This document provides detailed information about Palforzia Side Effects associated with peanut allergen powder. Some dosage forms listed on this page may not apply specifically to the brand name Palforzia.

Applies to peanut allergen powder: oral capsule, oral powder.

Important warnings This medicine can cause some serious health issues

Oral route (capsule; powder)

Peanut (Arachis hypogaea) Allergen Powder-dnfp can cause anaphylaxis, which may be life-threatening and can occur at any time during.

Prescribe injectable epinephrine, instruct and train patients on its appropriate use, and instruct patients to seek immediate medical care upon its use.

Do not administer Peanut (Arachis hypogaea) Allergen Powder-dnfp to patients with uncontrolled asthma.

Dose modifications may be necessary following an anaphylactic reaction.

Observe patients during and after administration of the Initial Dose Escalation and the first dose of each Up-Dosing level, for at least 60 minutes.

Because of the risk of anaphylaxis, Peanut (Arachis hypogaea) Allergen Powder-dnfp is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the Palforzia REMS.

Serious side effects of Palforzia

Along with its needed effects, peanut allergen powder (the active ingredient contained in Palforzia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking peanut allergen powder:

More common side effects

• chest tightness
• cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives, itching, skin rash
• nausea
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• stomach pain
• throat irritation and tightness
• trouble breathing
• unusual tiredness or weakness
• vomiting

Other side effects of Palforzia

Some side effects of peanut allergen powder may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• ear itching
• numbness or itching of the mouth
• runny nose
• sneezing

For healthcare professionals

Applies to peanut allergen powder: oral powder.

General adverse events

The most common adverse reactions included abdominal pain, vomiting, nausea, oral pruritus, oral paresthesia, throat irritation, cough, rhinorrhea, sneezing, throat tightness, wheezing, dyspnea, pruritus, urticaria, anaphylactic reaction, abdominal discomfort, upper abdominal pain, and ear pruritus.

The most common adverse reactions leading to discontinuation of treatment were abdominal pain, vomiting, nausea, and systemic allergic reaction, including anaphylaxis.^[Ref]

Dermatologic

• Very common (10% or more): Pruritus (up to 32.5%), urticaria (up to 28.4%)^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (up to 67.1%), vomiting (up to 36.5%), nausea (up to 32.3%), oral paresthesia (up to 13.6%), oral pruritus (up to 31.2%)
• Common (1% to 10%): Gastrointestinal reactions
• Uncommon (0.1% to 1%): Eosinophilic esophagitis^[Ref]

Abdominal pain included upper abdominal pain and abdominal discomfort.

Oral pruritus included tongue pruritus and lip pruritus.^[Ref]

Hypersensitivity

• Very common (10% or more): Anaphylactic reaction^[Ref]

Other

• Common (1% to 10%): Ear pruritus^[Ref]

Respiratory

• Very common (10% or more): Throat irritation (up to 40.3%), cough (up to 31.9%), rhinorrhea (up to 20.9%), sneezing (up to 20.2%), throat tightness (up to 14.1%), wheezing (up to 12.3%)
• Common (1% to 10%): Dyspnea^[Ref]

Further information

Palforzia side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer