Oxytrol Side Effects

Generic name: oxybutynin

Medically reviewed by Drugs.com. Last updated on Mar 26, 2024.

Note: This document contains side effect information about oxybutynin. Some dosage forms listed on this page may not apply to the brand name Oxytrol.

For healthcare professionals

Applies to oxybutynin: oral solution, oral syrup, oral tablet, oral tablet extended release, transdermal film extended release, transdermal gel.

General adverse events

The most common (incidence 5% or greater) adverse reactions were dry mouth, constipation, diarrhea, headache, somnolence, and dizziness.^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitations
• Uncommon (0.1% to 1%): Cardiac arrhythmia tachycardia, vasodilation, hypertension, flushing
• Frequency not reported: Heat stroke^[Ref]

Dermatologic

• Very common (10% or more): Dry skin, pruritus
• Common (1% to 10%): Flushing, rash
• Frequency not reported: Angioedema, hypohidrosis^[Ref]

Endocrine

• Postmarketing reports: Decreased lactation^[Ref]

Gastrointestinal

• Very common (10% or more): Dry mouth (up to 72%), constipation (up to 15%), nausea
• Common (1% to 10%): Diarrhea, dyspepsia, abdominal pain, vomiting, flatulence, gastroesophageal reflux disease
• Uncommon (0.1% to 1%): Abdominal discomfort
• Frequency not reported: Pseudo-obstruction in patients at risk (elderly or patients with constipation and treated with other drugs that decrease intestinal motility), decreased GI motility^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity
• Frequency not reported: Anaphylactic reaction^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection, urinary hesitation, urinary retention, dysuria, increased post void retention
• Frequency not reported: Impotence, suppression of lactation, cystitis, aggravation of prostatic hypertrophy^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Fungal infection^[Ref]

Local

• Very common (10% or more): Application site pruritus (16.8%)
• Common (1% to 10%): Application site erythema, application site vesicles, application site rash, application site macules^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Anorexia, fluid retention^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Back pain^[Ref]

Nervous system

• Very common (10% or more): Dizziness (up to 17%), somnolence (up to 14%), headache, drowsiness, confusion
• Common (1% to 10%): Dysgeusia
• Uncommon (0.1% to 1%): Dysphagia, convulsions
• Frequency not reported: Cognitive disorders in elderly, convulsions, agitation, nightmares, anxiety, paranoia, symptoms of depression, hallucinations, asthenia, insomnia, restlessness, dependence to this drug (in patients with history of drug or substance abuse)^[Ref]

Ocular

• Common (1% to 10%): Blurred vision, dry eye, abnormal vision
• Uncommon (0.1% to 1%): Angle closure glaucoma
• Frequency not reported: Onset of narrow-angle glaucoma, mydriasis, intraocular hypertension, amblyopia, cycloplegia, decreased lacrimation^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Dysphonia, thirst
• Frequency not reported: Falls, accidental injury^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, nervousness
• Uncommon (0.1% to 1%): Hallucinations, confusional state, agitation, memory impairment
• Frequency not reported: Psychotic disorder, anxiety, nightmares, paranoia, abnormal behavior^[Ref]

Respiratory

• Common (1% to 10%): Cough, oropharyngeal pain, dry throat, nasal dryness
• Uncommon (0.1% to 1%): Upper respiratory tract infection, rhinitis, chest discomfort, hoarseness
• Rare (0.01% to 0.1%): Nasal congestion, throat irritation^[Ref]

Other

Concomitant use of oxybutynin (the active ingredient contained in Oxytrol) with carbamazepine and dantrolene has been associated with adverse events suggestive of carbamazepine toxicity, such as vomiting, drowsiness, confusion, unsteadiness, slurred speech, and nystagmus.

See also:

Further information

Oxytrol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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