Oxydose Side Effects
Generic name: oxycodone
Medically reviewed by Drugs.com. Last updated on Apr 19, 2023.
Note: This document provides detailed information about Oxydose Side Effects associated with oxycodone. Some dosage forms listed on this page may not apply specifically to the brand name Oxydose.
Applies to oxycodone: oral capsule, oral capsule extended release, oral solution, oral tablet, oral tablet extended release.
Important warnings
This medicine can cause some serious health issues
Common side effects of Oxydose
Some side effects of oxycodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- difficulty having a bowel movement
- drowsiness
- lack or loss of strength
- relaxed and calm feeling
Less common side effects
- abnormal dreams
- anxiety
- belching
- burning feeling in the chest or stomach
- false or unusual sense of well-being
- heartburn
- hiccups
- indigestion
- stomach discomfort or upset
- tenderness in the stomach area
- trouble sleeping
- weight loss
Rare side effects
- absent, missed, or irregular menstrual periods
- bad, unusual or unpleasant (after) taste
- bloated or full feeling
- body aches or pain
- change in taste
- change in walking and balance
- changes in vision
- clumsiness or unsteadiness
- continuous ringing or buzzing or other unexplained noise in the ears
- crying
- decreased interest in sexual intercourse
- deep or fast breathing with dizziness
- delusions of persecution, mistrust, suspiciousness, or combativeness
- dental caries or tooth decay
- depression
- difficulty with speaking
- dry skin
- dryness or soreness of the throat
- excess air or gas in the stomach or bowels
- excessive muscle tone
- feeling of constant movement of self or surroundings
- feeling of unreality
- general feeling of discomfort or illness
- headache, severe and throbbing
- hearing loss
- hoarseness
- inability to have or keep an erection
- increase in body movements
- increased appetite
- increased cough
- irritability
- loss in sexual ability, desire, drive, or performance
- loss of heat from the body
- loss of memory
- loss of strength or energy
- muscle stiffness, tension, tightness, pain, or weakness
- neck pain
- numbness of the feet, hands, and around the mouth
- passing of gas
- problems with memory
- quick to react or overreact emotionally
- rapidly changing moods
- red, swollen skin
- restlessness
- runny nose
- scaly skin
- sensation of spinning
- sense of detachment from self or body
- swelling or inflammation of the mouth
- voice changes
Serious side effects of Oxydose
Along with its needed effects, oxycodone (the active ingredient contained in Oxydose) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking oxycodone:
Less common side effects
- chills
- cold sweats
- confusion
- difficult or labored breathing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fever
- tightness in the chest
- twitching
Rare side effects
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blood in the urine
- burning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain
- cough
- decrease in the frequency of urination
- decreased urine output
- difficult or painful urination
- difficulty in passing urine (dribbling)
- difficulty with swallowing
- dizziness
- dry mouth
- fainting
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling of warmth or heat
- flushing or redness of the skin, especially on the face and neck
- frequent urination
- headache
- hives, itching, or skin rash
- increase in heart rate
- increased thirst
- increased volume of pale, dilute urine
- lightheadedness
- muscle pain or cramps
- nausea
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid breathing
- rapid weight gain
- seizures
- severe constipation
- severe vomiting
- stomach pain
- sunken eyes
- sweating
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- thirst
- trembling or shaking of the hands or feet
- unusual tiredness or weakness
- unusual weight gain or loss
- vomiting
- wrinkled skin
Incidence not known
- blurred vision
- choking
- clay-colored stools
- cold, clammy skin
- dark urine
- darkening of the skin
- diarrhea
- fast, weak pulse
- gagging
- irregular, fast, slow, or shallow breathing
- loss of appetite
- loss of consciousness
- pale or blue lips, fingernails, or skin
- unpleasant breath odor
- very slow heartbeat
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking oxycodone:
Symptoms of overdose
- change in consciousness
- chest pain or discomfort
- cold, clammy skin
- constricted, pinpoint, or small pupils (black part of the eye)
- coughing that sometimes produces a pink frothy sputum
- decreased awareness or responsiveness
- increased sweating
- irregular, fast, or slow, or shallow breathing
- loss of consciousness
- no muscle tone or movement
- pale or blue lips, fingernails, or skin
- sleepiness or unusual drowsiness
- slow or irregular heartbeat
- swelling in the legs and ankles,
For healthcare professionals
Applies to oxycodone: compounding powder, oral capsule, oral capsule extended release, oral concentrate, oral solution, oral tablet, oral tablet extended release.
General adverse events
The most commonly reported adverse reactions in adults included constipation, nausea, somnolence, dizziness, vomiting, pruritus, headache, dry mouth, asthenia, and sweating. In pediatric patients, the most frequently observed adverse reactions included vomiting, nausea, headache, pyrexia, and constipation.[Ref]
Nervous system
- Very common (10% or more): Headache (14%, pediatrics)
- Common (1% to 10%): Dizziness (pediatrics)
- Frequency not reported: Confusion, hypertonia, hypesthesia, nervousness, neuralgia, personality disorder, tremor, migraine
- Postmarketing reports: Serotonin syndrome, hyperalgesia, allodynia[Ref]
Respiratory
- Frequency not reported: Apnea, respiratory arrest, bronchitis, cough increased, dyspnea, epistaxis, laryngismus, lung disorder, pharyngitis, rhinitis, sinusitis[Ref]
Severe adverse effects such as respiratory depression can be treated with the opioid antagonist naloxone.[Ref]
Gastrointestinal
- Very common (10% or more): Nausea (23% to 27%), constipation (23% to 26%), vomiting (12% to 14%)
- Frequency not reported: Abdominal pain, anorexia, diarrhea, dyspepsia, dysphagia, gingivitis, glossitis[Ref]
In pediatric studies with the oral extended release product, gastrointestinal adverse events were reported in 40% of patients 11 to 16 years of age (56 of 140); vomiting, nausea, constipation, and diarrhea were experienced by 21%, 15%, 9%, and 6%, respectively. Abdominal pain and gastroesophageal reflux disease were reported in 1% to less than 5% of patients.[Ref]
Psychiatric
- Frequency not reported: Paranoia, psychosis, hallucinations, agitation, anxiety[Ref]
Dermatologic
- Common (1% to 10%): Pruritus, hyperhidrosis, rash
- Frequency not reported: Herpes simplex, rash, sweating, urticaria[Ref]
Hepatic
- Frequency not reported: Increased hepatic enzymes
Cardiovascular
- Frequency not reported: QTc prolongation at higher doses, deep thrombophlebitis, heart failure, hemorrhage, hypotension, palpitation, tachycardia, edema, peripheral edema, vasodilation, circulatory collapse[Ref]
Genitourinary
- Common (1% to 10%): Dysuria, urinary retention
- Frequency not reported: Urinary tract infection[Ref]
Hypersensitivity
- Frequency not reported: Allergic reaction
- Postmarketing reports: Anaphylaxis[Ref]
Immunologic
- Frequency not reported: Flu syndrome, infection, sepsis[Ref]
Metabolic
- Common (1% to 10%): Decreased appetite (pediatrics)
- Frequency not reported: Gout, hyperglycemia, iron deficiency anemia
- Postmarketing reports: Hypoglycemia[Ref]
Musculoskeletal
- Frequency not reported: Back pain, neck pain, arthralgia, arthritis, bone pain, myalgia, pathological fracture[Ref]
Ocular
- Frequency not reported: Photosensitivity reaction, amblyopia[Ref]
Other
- Very common (10% or more): Pyrexia (11%, pediatrics)
- Frequency not reported: Chills and fever, accidental injury[Ref]
Endocrine
Opioids:
- Postmarketing reports: Adrenal insufficiency, androgen deficiency[Ref]
References
1. Leow KP, Smith MT, Watt JA, Williams BE, Cramond T (1992) "Comparative oxycodone pharmacokinetics in humans after intravenous, oral, and rectal administration." Ther Drug Monit, 14, p. 479-84
2. (2001) "Product Information. OxyContin (oxycodone)." Purdue Frederick Company
3. (2023) "Product Information. Xtampza ER (oxyCODONE)." Patheon, SUPPL-21
4. Leow KP, Smith MT, Williams B, Cramond T (1992) "Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer." Clin Pharmacol Ther, 52, p. 487-95
5. Glare P, Walsh D (1991) "Dose-ranging study of oxycodone for advanced cancer pain (meeting abstract)." Proc Annu Meet Am Soc Clin Oncol, 10, a1201
6. Glare PA, Walsh TD (1993) "Dose-ranging study of oxycodone for chronic pain in advanced cancer." J Clin Oncol, 11, p. 973-8
7. Sunshine A, Olson NZ, Zighelboim I, Decastro A (1993) "Ketoprofen, acetaminophen plus oxycodone, and acetaminophen in the relief of postoperative pain." Clin Pharmacol Ther, 54, p. 546-55
8. Cerner Multum, Inc. "UK Summary of Product Characteristics."
9. (2016) "Product Information. Xtampza ER (oxycodone)." Patheon
10. Fishbain DA, Goldberg M, Rosomoff RS, Rosomoff H (1988) "Atypical withdrawal syndrome (organic delusional syndrome) secondary to oxycodone detoxification ." J Clin Psychopharmacol, 8, p. 441-2
11. Fanoe S, Jensen GB, Sjogren P, Korsgaard MP, Grunnet M (2008) "Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro." Br J Clin Pharmacol, 67, p. 172-9
12. Gardos G (1977) "Dyskinesia after discountinuation of compound analgesic containing oxycodone ." Lancet, 1, p. 759-60
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More about Oxydose (oxycodone)
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- Reviews (2)
- Latest FDA alerts (3)
- Dosage information
- During pregnancy
- Drug class: Opioids (narcotic analgesics)
- Breastfeeding
Patient resources
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Professional resources
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Further information
Oxydose side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.