Orbivan CF Side Effects

Generic name: acetaminophen / butalbital

Medically reviewed by Drugs.com. Last updated on Dec 18, 2023.

Note: This document provides detailed information about Orbivan CF Side Effects associated with acetaminophen / butalbital. Some dosage forms listed on this page may not apply specifically to the brand name Orbivan CF.

Applies to acetaminophen / butalbital: oral capsule, oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet; capsule)

Hepatotoxicity. Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death.

Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product.

Serious side effects of Orbivan CF

Along with its needed effects, acetaminophen / butalbital may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / butalbital:

More common

• dizziness
• lightheadedness
• sleepiness
• trouble breathing

Less common

• anxiety
• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• blood in the urine or stools
• chest tightness
• chills
• cough or hoarseness
• diarrhea
• difficulty swallowing
• discouragement
• dry mouth
• excitement
• fainting
• false or unusual sense of well-being
• fast, pounding, or irregular heartbeat or pulse
• feeling sad or empty
• headache
• heavy eyelids
• high energy
• hives, itching, skin rash
• hot spells
• hyperventilation
• irregular heartbeats
• irritability
• joint or muscle pain
• lack of appetite
• loss of interest or pleasure
• lower back or side pain
• mental confusion
• nervousness
• painful or difficult urination
• pinpoint red spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• red irritated eyes
• red skin lesions, often with a purple center
• restlessness
• seizures
• shaky feeling
• sluggishness
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• trouble concentrating
• trouble sleeping
• unusual bleeding or bruising
• unusual tiredness or weakness

Incidence not known

• dark urine
• loss of appetite
• nausea or vomiting
• stomach pain, severe
• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / butalbital:

Symptoms of overdose

• black, tarry stools
• bloody or cloudy urine
• blurred vision
• change in consciousness
• chills
• confusion
• dark urine
• difficult or painful urination
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fever
• headache
• irregular, fast or slow, or shallow breathing
• itching
• light-colored stools
• loss of appetite
• loss of consciousness
• nausea
• pale or blue lips, fingernails, or skin
• sleepiness
• stomach pain
• sudden decrease in amount of urine
• sweating
• trouble breathing
• unpleasant breath odor
• unusual tiredness or weakness
• vomiting of blood
• yellow eyes or skin

Other side effects of Orbivan CF

Some side effects of acetaminophen / butalbital may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• bloated
• constipation
• continuing ringing or buzzing or other unexplained noise in the ears
• dry mouth
• earache
• excess air or gas in the stomach or intestines
• full feeling
• hearing loss
• heartburn
• increased sweating
• indigestion
• leg pain
• passing gas
• stuffy nose

For healthcare professionals

Applies to acetaminophen / butalbital: oral capsule, oral tablet.

General

The most frequently reported adverse events have included drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, abdominal pain, and intoxicated feeling.^[Ref]

Hepatic

Acetaminophen:

• Frequency not reported: Liver failure^[Ref]

Acute liver failure has been reported with acetaminophen use; many case have been associated with use at doses in excess of 4 g/day, and often involving more than 1 acetaminophen-containing product.^[Ref]

Hypersensitivity

Butalbital-Acetaminophen:

• Uncommon (0.1% to 1%): Allergic reactions
• Postmarketing reports: Anaphylaxis

Acetaminophen:

• Postmarketing reports: Anaphylaxis^[Ref]

Dermatologic

Butalbital-Acetaminophen:

• Uncommon (0.1% to 1%): Hyperhidrosis, pruritus
• Frequency not reported: Toxic epidermal necrolysis, erythema multiforme

Acetaminophen:

• Rare (less than 0.1%): Serious skin reactions such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and toxic epidermal necrolysis
• Frequency not reported: Rash^[Ref]

Several cases of dermatologic reactions including toxic epidermal necrolysis and erythema multiforme have been reported.^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Agitation, euphoria^[Ref]

Nervous system

• Common (1% to 10%): Drowsiness, lightheadedness, dizziness, sedation
• Uncommon (0.1% to 1%): Headache, shaky feeling, tingly, fainting, numbness, seizures, mental confusion, excitement or depression due to intolerance^[Ref]

Respiratory

• Common (1% to 10%): Shortness of breath
• Uncommon (0.1% to 1%): Nasal congestion^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting, abdominal pain
• Uncommon (0.1% to 1%): Dry mouth, difficulty swallowing, heartburn, flatulence, constipation^[Ref]

Hematologic

Acetaminophen:

• Frequency not reported: Thrombocytopenia, agranulocytosis^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Tachycardia^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Leg pain, muscle fatigue^[Ref]

Other

• Common (1% to 10%): Intoxicated feeling
• Uncommon (0.1% to 1%): Fatigue, high energy, heavy eyelids, sluggishness, hot spells, fever, earache, tinnitus^[Ref]

Renal

• Uncommon (0.1% to 1%): Diuresis,^[Ref]

Further information

Orbivan CF side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer