Optimine Side Effects
Generic name: azatadine
Note: This document contains side effect information about azatadine. Some dosage forms listed on this page may not apply to the brand name Optimine.
Applies to azatadine: oral tablet.
Nervous system
Nervous system side effects have commonly included central nervous system depression with resulting drowsiness. Azatadine (the active ingredient contained in Optimine) has also caused dizziness and affected coordination.[Ref]
The drowsiness caused by azatadine may subside in some patients following prolonged use. Patients should be warned against driving, as well as concomitant ingestion of alcohol and other sedative-hypnotic drugs, while taking azatadine.
At dosages above what is normally recommended, dystonic reactions have occurred.[Ref]
Gastrointestinal
Gastrointestinal side effects have included dry mouth and constipation due to anticholinergic effects. Patients have also experienced epigastric distress and nausea. Increased appetite has been reported.[Ref]
Cardiovascular
Cardiovascular side effects have included hypotension, tachycardia, and palpitations.[Ref]
Ocular
Ocular side effects have included blurred vision, diplopia, and dry eyes due to cholinergic blockade.[Ref]
Genitourinary
Genitourinary side effects have included dysuria, urinary hesitancy, decrease in urinary flow, and in rare cases, acute urinary retention. These urinary tract effects may have been due to azatadine (the active ingredient contained in Optimine) s anticholinergic effects.[Ref]
Hematologic
Hematologic side effects have included reports of bone marrow suppression, thrombocytopenia, and aplastic anemia.[Ref]
Respiratory
Respiratory side effects have included thickening of bronchial secretions.[Ref]
Hypersensitivity
Hypersensitivity reactions to azatadine (the active ingredient contained in Optimine) have included rash and urticaria.[Ref]
More about Optimine (azatadine)
- Check interactions
- Drug images
- Dosage information
- During pregnancy
- Drug class: antihistamines
- Breastfeeding
Related treatment guides
References
1. Schuller DE, Turkewitz D "Adverse effects of antihistamines." Postgrad Med 79 (1986): 75-86
2. "Azatadine (optimine)--a new antihistamine." Med Lett Drugs Ther 19 (1977): 77-9
3. Luscombe DK, Nicholls PJ, Spencer PS "Effect of azatadine on human performance." Br J Clin Pract 34 (1980): 75-9
4. Small P, Barrett D, Biskin N "Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation." Ann Allergy 64 (1990): 129-31
5. Joske DJ "Dystonic reaction to azatadine." Med J Aust 141 (1984): 449
6. Wilson JD, Hillas JL, Somerfield SD "Azatadine maleate (Zadine): evaluation in the management of allergic rhinitis." N Z Med J 94 (1981): 79-81
7. Kaminszczik I, Barbon L "Relieving symptoms of upper respiratory allergies and the common cold: azatadine maleate/pseudoephedrine sulfate syrup versus placebo." J Int Med Res 11 (1983): 101-7
8. Luscombe DK, Nicholls PJ, Parish PA "Comparison of the effects of azatadine maleate and terfenadine on human performance." Pharmatherapeutica 3 (1983): 370-5
9. "Product Information. Optimine (azatadine)." Schering Corporation (2001):
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.