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Nexavar Side Effects

Generic name: sorafenib

Medically reviewed by Drugs.com. Last updated on Jan 16, 2024.

Note: This document contains side effect information about sorafenib. Some dosage forms listed on this page may not apply to the brand name Nexavar.

Applies to sorafenib: oral tablet.

Serious side effects of Nexavar

Along with its needed effects, sorafenib (the active ingredient contained in Nexavar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sorafenib:

More common

Less common

Incidence not known

Other side effects of Nexavar

Some side effects of sorafenib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to sorafenib: oral tablet.

Gastrointestinal

Very common (10% or more): Diarrhea (39%), nausea, vomiting, constipation, abdominal pain, mouth pain

Common (1% to 10%): Stomatitis, dry mouth, glossodynia, dyspepsia, dysphagia, gastroesophageal reflux disease, mucosal inflammation

Uncommon (0.1% to 1%): Pancreatitis, gastritis, GI perforations[Ref]

Dermatologic

Very common (10% or more): Pruritus (20%), dry skin (13%), erythema (10%), rash, alopecia, hand foot skin reaction

Common (1% to 10%): Keratoacanthoma/squamous cell cancer of the skin, dermatitis exfoliative, acne, skin desquamation, hyperkeratosis

Uncommon (0.1% to 1%): Eczema, erythema multiforme

Rare (less than 0.1%): Radiation recall dermatitis, Stevens-Johnson syndrome (SJS), leucocytoclastic vasculitis, toxic epidermal necrolysis (TEN)[Ref]

Endocrine

Common (1% to 10%): Hypothyroidism

Uncommon (0.1% to 1%): Hyperthyroidism[Ref]

Cardiovascular

Very common (10% or more): Hypertension (41%)

Common (1% to 10%): Congestive heart failure, myocardial ischemia, myocardial infarction

Rare (less than 0.1%): QT prolongation[Ref]

Hematologic

Very common (10% or more): Lymphopenia, GI hemorrhage, respiratory tract hemorrhage, cerebral hemorrhage, hypertension

Common (1% to 10%): Leukopenia, neutropenia, anemia, thrombocytopenia, flushing

Uncommon (0.1% to 1%): Hypertensive crisis, INR abnormal, prothrombin level abnormal[Ref]

Respiratory

Very common (10% or more): Cough (15%), dysphonia (13%), dyspnea (12%)

Common (1% to 10%): Rhinorrhea, dysphonia, hoarseness, epistaxis

Uncommon (0.1% to 1%): Interstitial lung disease-like events (e.g., pneumonitis, radiation pneumonitis, acute respiratory distress)[Ref]

Nervous system

Very common (10% or more): Headache

Common (1% to 10%): Peripheral sensory neuropathy, dysgeusia, paresthesia, dizziness

Uncommon (0.1% to 1%): Reversible posterior leukoencephalopathy (sometimes fatal)

Frequency not reported: Encephalopathy (sometimes fatal)[Ref]

Musculoskeletal

Very common (10% or more): Pain in extremity (15%), joint pain (10%), arthralgia, bone pain

Common (1% to 10%): Myalgia, muscle spasm

Rare (less than 0.1%): Rhabdomyolysis[Ref]

Immunologic

Common (1% to 10%): Folliculitis, influenza-like illness[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity reactions (e.g., skin reactions, urticaria), anaphylactic reaction

Rare (less than 0.1%): Angioedema[Ref]

Metabolic

Very common (10% or more): Anorexia (11%), hypophosphatemia, weight loss, increased amylase, increased lipase

Common (1% to 10%): Hypocalcemia, hypokalemia, hyponatremia

Uncommon (0.1% to 1%): Dehydration, transient increase in blood alkaline phosphatase[Ref]

Psychiatric

Common (1% to 10%): Depression[Ref]

Genitourinary

Common (1% to 10%): Erectile dysfunction, urinary tract infection

Uncommon (0.1% to 1%): Gynecomastia[Ref]

Hepatic

Common (1% to 10%): Transient increase in transaminases

Uncommon (0.1% to 1%): Bilirubin increased, jaundice, cholecystitis, cholangitis

Rare (less than 0.1%): Drug induced hepatitis (sometimes fatal), nephrotic syndrome[Ref]

Other

Very common (10% or more): Fatigue (17%), pain

fever

Common (1% to 10%): Tinnitus, asthenia[Ref]

Frequently asked questions

References

1. Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc. 2005.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.