Nebivolol / Valsartan Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 1, 2024.

Applies to nebivolol / valsartan: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

When pregnancy is detected, discontinue nebivolol/valsartan as soon as possible.

Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Serious side effects

Along with its needed effects, nebivolol / valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nebivolol / valsartan:

Incidence not known

• blurred vision
• chest pain or tightness
• confusion
• decreased urine output
• difficult breathing
• dilated neck veins
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• extreme fatigue
• irregular breathing
• irregular heartbeat
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• stomach pain
• sweating
• swelling of the face, fingers, feet, or lower legs
• trouble breathing
• unusual tiredness or weakness
• weakness or heaviness of the legs
• weight gain

For healthcare professionals

Applies to nebivolol / valsartan: oral tablet.

Cardiovascular adverse events

• Frequency not reported: Hypotension

Nebivolol:

• Postmarketing reports: Atrioventricular block (both second and third degree), myocardial infarction, Raynaud's phenomenon, peripheral ischemia/claudication

Valsartan:

• Postmarketing reports: Vasculitis^[Ref]

Dermatologic

• Rare (0.01% to 0.1%): Angioedema

Nebivolol:

• Postmarketing reports: Pruritus, psoriasis, various rashes, various skin disorders, urticaria, allergic vasculitis

Valsartan:

• Postmarketing reports: Angioedema, alopecia, bullous dermatitis^[Ref]

Gastrointestinal

• Postmarketing reports: Vomiting^[Ref]

Genitourinary

• Postmarketing reports: Erectile dysfunction

Nebivolol:

• Postmarketing reports: Thrombocytopenia

Valsartan:

• Postmarketing reports: Thrombocytopenia^[Ref]

Hepatic

Nebivolol:

• Postmarketing reports: Abnormal hepatic function (including increased AST, ALT, and bilirubin)

Valsartan:

• Postmarketing reports: Elevated liver enzymes, hepatitis

Valsartan:

• Postmarketing reports: Angioedema^[Ref]

Metabolic

• Common (1% to 10%): Hyperkalemia

Valsartan:

• Postmarketing reports: Hyperkalemia^[Ref]

Nervous system

• Postmarketing reports: Somnolence, syncope, vertigo

Nebivolol:

• Postmarketing reports: Acute renal failure

Valsartan:

• Postmarketing reports: Impaired renal function, renal failure^[Ref]

Respiratory

Nebivolol:

• Postmarketing reports: Acute pulmonary edema, bronchospasm^[Ref]

Further information

Nebivolol/valsartan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer