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Nebivolol / valsartan Side Effects

In Summary

More frequently reported side effects include: increased serum potassium. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to nebivolol / valsartan: oral tablet

As well as its needed effects, nebivolol / valsartan may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking nebivolol / valsartan, check with your doctor immediately:

Incidence not known:
  • Abdominal or stomach pain
  • blurred vision
  • chest pain
  • confusion
  • decreased urine output
  • difficult breathing
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing
  • unusual tiredness or weakness
  • weakness or heaviness of the legs
  • weight gain

For Healthcare Professionals

Applies to nebivolol / valsartan: oral tablet


Frequency not reported: Hypotension

Postmarketing reports: Atrioventricular block (both second and third degree), myocardial infarction, Raynaud's phenomenon, peripheral ischemia/claudication

Postmarketing reports: Vasculitis[Ref]


Rare (0.01% to 0.1%): Angioedema

Postmarketing reports: Pruritus, psoriasis, various rashes, various skin disorders, urticaria, allergic vasculitis

Postmarketing reports: Angioedema, alopecia, bullous dermatitis[Ref]


Postmarketing reports: Vomiting[Ref]


Postmarketing reports: Erectile dysfunction

Postmarketing reports: Thrombocytopenia

Postmarketing reports: Thrombocytopenia[Ref]


Postmarketing reports: Abnormal hepatic function (including increased AST, ALT, and bilirubin)

Postmarketing reports: Elevated liver enzymes, hepatitis

Postmarketing reports: Angioedema[Ref]


Common (1% to 10%): Hyperkalemia

Postmarketing reports: Hyperkalemia[Ref]

Nervous system

Postmarketing reports: Somnolence, syncope, vertigo

Postmarketing reports: Acute renal failure

Postmarketing reports: Impaired renal function, renal failure[Ref]


Postmarketing reports: Acute pulmonary edema, bronchospasm[Ref]


1. "Product Information. Byvalson (nebivolol-valsartan)." Actavis Pharma, Inc., Parsippany, NJ.

It is possible that some side effects of nebivolol / valsartan may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.