Nebivolol / Valsartan Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 1, 2024.
Applies to nebivolol / valsartan: oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
When pregnancy is detected, discontinue nebivolol / valsartan as soon as possible.
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Precautions
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.
Dizziness, lightheadedness, or fainting may occur after the first dose, especially if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.
Check with your doctor right away if you experience dizziness, fainting, confusion, muscle pain, weakness, or a fast heartbeat. Use extra care if you exercise or if the weather is hot. Heavy sweating can cause dehydration (loss of too much water) or electrolyte imbalances (loss of sodium or potassium in the body).
Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt which may cause low blood pressure.
Do not suddenly Stop taking nebivolol / valsartan without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.
This medicine may worsen the symptoms of heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort, dilated neck veins, extreme fatigue, irregular breathing, an irregular heartbeat, swelling of the face, fingers, feet, or lower legs, weight gain, or trouble breathing.
Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Do not use supplements or salt substitutes containing potassium without first checking with your doctor.
This medicine may cause serious allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery.
This medicine may cause serious kidney problem. Check with your doctor right away if you have agitation, coma, confusion, decreased urine output, decreased urine output, depression, dizziness, headache, hostility, irritability, lethargy, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face ankles, or hands, unusual tiredness or weakness.
This medicine may cover up signs of low blood sugar in patients who have diabetes or are fasting (eg, surgery, not eating regularly, vomiting), such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.
Do not take other medicines unless they have been discussed with your doctor. This includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.
Serious side effects
Along with its needed effects, nebivolol / valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking nebivolol / valsartan:
Incidence not known
- blurred vision
- chest pain or tightness
- confusion
- decreased urine output
- difficult breathing
- dilated neck veins
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- extreme fatigue
- irregular breathing
- irregular heartbeat
- nausea or vomiting
- nervousness
- numbness or tingling in the hands, feet, or lips
- stomach pain
- sweating
- swelling of the face, fingers, feet, or lower legs
- trouble breathing
- unusual tiredness or weakness
- weakness or heaviness of the legs
- weight gain
For healthcare professionals
Applies to nebivolol / valsartan: oral tablet.
Cardiovascular adverse events
- Frequency not reported: Hypotension
Nebivolol:
- Postmarketing reports: Atrioventricular block (both second and third degree), myocardial infarction, Raynaud's phenomenon, peripheral ischemia/claudication
Valsartan:
- Postmarketing reports: Vasculitis[Ref]
Dermatologic
- Rare (0.01% to 0.1%): Angioedema
Nebivolol:
- Postmarketing reports: Pruritus, psoriasis, various rashes, various skin disorders, urticaria, allergic vasculitis
Valsartan:
- Postmarketing reports: Angioedema, alopecia, bullous dermatitis[Ref]
Gastrointestinal
- Postmarketing reports: Vomiting[Ref]
Genitourinary
- Postmarketing reports: Erectile dysfunction
Nebivolol:
- Postmarketing reports: Thrombocytopenia
Valsartan:
- Postmarketing reports: Thrombocytopenia[Ref]
Hepatic
Nebivolol:
- Postmarketing reports: Abnormal hepatic function (including increased AST, ALT, and bilirubin)
Valsartan:
- Postmarketing reports: Elevated liver enzymes, hepatitis
Valsartan:
- Postmarketing reports: Angioedema[Ref]
Metabolic
- Common (1% to 10%): Hyperkalemia
Valsartan:
- Postmarketing reports: Hyperkalemia[Ref]
Nervous system
- Postmarketing reports: Somnolence, syncope, vertigo
Nebivolol:
- Postmarketing reports: Acute renal failure
Valsartan:
- Postmarketing reports: Impaired renal function, renal failure[Ref]
Respiratory
Nebivolol:
- Postmarketing reports: Acute pulmonary edema, bronchospasm[Ref]
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References
1. (2016) "Product Information. Byvalson (nebivolol-valsartan)." Actavis Pharma, Inc.
More about nebivolol / valsartan
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- Drug class: miscellaneous antihypertensive combinations
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Further information
Nebivolol/valsartan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.