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Natrecor Side Effects

Generic name: nesiritide

Medically reviewed by Last updated on May 21, 2023.

Note: This document contains side effect information about nesiritide. Some dosage forms listed on this page may not apply to the brand name Natrecor.

Applies to nesiritide: intravenous powder for injection.


You should not use this medicine if you have very low blood pressure, or if your heart cannot pump blood properly.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to nesiritide: intravenous powder for injection.


The most frequently reported side effects were hypotension, headache, nausea, renal impairment, and back pain.[Ref]


Very common (10% or more): Hypotension (12%)[Ref]


Very common (10% or more): GFR decreased (up to 31.4%), serum creatinine increased (up to 28%)[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness[Ref]


Postmarketing reports: Pruritus, rash[Ref]


Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Hypoglycemia[Ref]


Common (1% to 10%): Nausea[Ref]


Postmarketing reports: Infusion site extravasation[Ref]


Postmarketing reports: Hypersensitivity reaction[Ref]


1. Product Information. Natrecor (nesiritide). Scios Inc. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.