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Natrecor Side Effects

Generic Name: nesiritide

Note: This page contains side effects data for the generic drug nesiritide. It is possible that some of the dosage forms included below may not apply to the brand name Natrecor.

In Summary

Common side effects of Natrecor include: asymptomatic hypotension, hypotension, symptomatic hypotension, and increased serum creatinine. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to nesiritide: intravenous powder for solution

As well as its needed effects, nesiritide (the active ingredient contained in Natrecor) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking nesiritide, check with your doctor immediately:

More common:
  • Low blood pressure
Less common:
  • Bluish lips or skin
  • chest pain, tightness, or discomfort
  • cool, clammy skin
  • difficulty in breathing or shortness of breath
  • dizziness
  • fainting
  • lightheadedness
  • fast, slow, or irregular heartbeat
  • unusual tiredness or weakness

Minor Side Effects

Some nesiritide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Headache
Less common:
  • Abdominal or stomach pain
  • anxiety
  • back pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings on the skin
  • change in vision
  • confusion
  • coughing or spitting up blood
  • fever
  • increased cough
  • itching skin
  • leg cramps
  • nausea
  • pain or irritation at the injection site
  • pale skin, unusual bleeding or bruising
  • rash
  • sleepiness or unusual drowsiness
  • sleeplessness
  • sweating
  • trembling or shakiness
  • vomiting

For Healthcare Professionals

Applies to nesiritide: intravenous powder for injection


The most frequently reported side effects were hypotension, headache, nausea, renal impairment, and back pain.[Ref]


Very common (10% or more): Hypotension (12%)[Ref]


Very common (10% or more): GFR decreased (up to 31.4%), serum creatinine increased (up to 28%)[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness[Ref]


Postmarketing reports: Pruritus, rash[Ref]


Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Hypoglycemia[Ref]


Common (1% to 10%): Nausea[Ref]


Postmarketing reports: Infusion site extravasation[Ref]


Postmarketing reports: Hypersensitivity reaction[Ref]


1. "Product Information. Natrecore (nesiritide)" Scios Inc, Sunnyvale, CA.

It is possible that some side effects of Natrecor may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.