Mycifradin Side Effects
Generic Name: neomycin
Note: This page contains information about the side effects of neomycin. Some of the dosage forms included on this document may not apply to the brand name Mycifradin.
For the Consumer
Applies to neomycin: oral solution, oral tablet
In addition to its needed effects, some unwanted effects may be caused by neomycin (the active ingredient contained in Mycifradin). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking neomycin:Rare
- Any loss of hearing
- difficulty in breathing
- greatly decreased frequency of urination or amount of urine
- increased amount of gas
- increased thirst
- light-colored, frothy, fatty-appearing stools
- ringing or buzzing or a feeling of fullness in the ears
- skin rash
Minor Side Effects
Some of the side effects that can occur with neomycin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common:
- Irritation or soreness of the mouth or rectal area
- nausea or vomiting
For Healthcare Professionals
Applies to neomycin: compounding powder, oral solution, oral tablet
Since oral neomycin (the active ingredient contained in Mycifradin) is absorbed systemically after oral administration, its use may result in nephrotoxicity, neurotoxicity and/or ototoxicity, even at recommended doses and in patients with normal renal function.[Ref]
The major renal side effect of oral neomycin (the active ingredient contained in Mycifradin) is nephrotoxicity, which has occurred even at recommended doses and in patients with normal renal function.[Ref]
Early signs of nephropathy include mild proteinuria, sloughing of renal tubular epithelial cells, formation of cellular casts, and decreases in creatinine clearance. Often there is a high output renal failure where daily urine volume may appear unchanged until significant increases in serum creatinine and BUN levels occur.
Neomycin damages renal tubules by causing tubular epithelial cell necrosis. It is considered the most nephrotoxic aminoglycoside.[Ref]
Early symptoms of neomycin-induced auditory toxicity may manifest as high tone hearing loss, tinnitus, or a feeling of fullness in the ear, or its onset may be asymptomatic. If ototoxicity occurs, the onset of hearing loss is between several days to 6 weeks after therapy begins; however, it may not occur for months or years after neomycin (the active ingredient contained in Mycifradin) has been discontinued. Symptoms of vestibulotoxicity may include tinnitus, vertigo and ataxia.
Neomycin is considered more ototoxic than vestibulotoxic. It progressively accumulates in the inner ear and which leads to sensory hair cell loss in the in the cochlea and damage to the stria vascularis. In an animal study, neomycin was found to be more ototoxic than gentamicin, kanamycin and dihydrostreptomycin.
One case report series describes 5 cases of hearing impairment associated with long-term oral neomycin therapy for hepatic encephalopathy. Doses ranged from 2 to 12 g/day and were administered for 8 to 28 months; in 2 cases paromomycin was also administered. Renal failure did not occur.[Ref]
Nervous system side effects associated with oral neomycin therapy have included neuromuscular blockade, respiratory paralysis, and eighth cranial nerve damage with hearing loss, even at recommended doses and in patients with normal renal function. Symptoms of neurotoxicity include numbness, tingling, muscle twitching, and convulsions.[Ref]
Oral neomycin (the active ingredient contained in Mycifradin) therapy may result in overgrowth of nonsusceptible organisms, especially fungi.[Ref]
A case of fatal Candida albicans pyelonephritis and septicemia following preoperative bowel preparation with oral neomycin and bacitracin has been reported.[Ref]
Gastrointestinal side effects most commonly include nausea, vomiting and diarrhea. Clostridium difficile colitis has also been reported with oral neomycin (the active ingredient contained in Mycifradin) therapy.[Ref]
1. "Product Information. Neomycin (neomycin)" Pharma-Tek, Huntington, NY.
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3. Lowry LD, May M, Pastore P "Acute histopathologic inner ear changes in deafness due to neomycin: a case report." Ann Otol Rhinol Laryngol 82 (1973): 876-80
4. Hasfurther DL, Bailey PL "Failure of neuromuscular blockade reversal after rocuronium in a patient who received oral neomycin." Can J Anaesth 43 (1996): 617-20
5. Berk DP, Chalmers T "Deafness complicating antibiotic therapy of hepatic encephalopathy." Ann Intern Med 73 (1970): 393-6
6. Greenberg LH, Momary H "Audiotoxicity and nephrotoxicity due to orally administered neomycin." JAMA 194 (1965): 237-8
7. Langman AW "Neomycin ototoxicity." Otolaryngol Head Neck Surg 110 (1994): 441-4
8. Thomas J, Marion MS, Hinojosa R "Neomycin ototoxicity." Am J Otolaryngol 13 (1992): 54-5
9. Ward KM, Rounthwaite FJ "Neomycin ototoxicity." Ann Otol Rhinol Laryngol 87 (1978): 211-5
10. Crosby DL "Fatal candidiasis following colonic sterilisation with neomycin and bacitracin." Br J Urol 39 (1967): 479-81
11. Bolton RP "Clostridium difficile-associated colitis after neomycin treated with metronidazole." Br Med J 2 (1979): 1479-80
12. Faergeman O "Effects and side-effects of treatment of hypercholesterolemia with cholestyramine and neomycin." Acta Med Scand 194 (1973): 165-7
Not all side effects for Mycifradin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about Mycifradin (neomycin)
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