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Neomycin use while Breastfeeding

Drugs containing Neomycin: Neosporin, Maxitrol, Cortisporin Otic, Triple Antibiotic, Pediotic, Cortisporin-TC, Neo-Poly-Dex, Neosporin Ophthalmic, Antibiotic Ear, Dexacine, Show all 90 »Cortomycin Eye Ointment, Cortisporin Cream, Septa, Triple Antibiotic Ophthalmic Ointment, Neo-Synalar, Neo-Polycin HC, Antibiotic Plus Pain Relief, Dexasporin, Cortisporin Ophthalmic Suspension, Triple Antibiotic Plus, Coly-Mycin S, ProCoMycin, Poly-Dex, Neo-Tab, Neosporin Ophthalmic Ointment, Ocu-Spore-G, Neoptic, Antibiotic with Pramoxine, Neocin-PG, Neocidin Ophthalmic Solution, AK-Spore, Cortomycin Suspension, Neo/PolyB/HC, Neosporin + Pain Relief Cream, Mycifradin, Casporyn HC, Neosporin G U Irrigant, Statrol, Cortomycin, Neo-Fradin, AK-Spore HC Otic Suspension, Drotic, Masporin Otic, Cortatrigen Modified, Otimar, Otocort Sterile Suspension, Myciguent, UAD Otic, Cortatrigen, Cort-Biotic, Oti-Sone, Otocort Sterile Solution, Campho-Phenique Maximum Strength, Ocu-Trol, Neo-Polycin, Medi-Quik, Ocu-Spore-B, Neocin, Ocutricin, AK-Spore Ointment, Neocidin, Sx1 Medicated Post-Operative System, Tribiotic Plus, First Aid Triple Antibiotic with Pain Reliever, Cortisporin Ointment, Cortisporin Ophthalmic Ointment, Neotricin HC, Ocu-Cort, Triple Antibiotic HC Ophthalmic Ointment, Neo-Poly-Bac, Mycitracin Triple Antibiotic, Curad Triple Antibiotic, AK-Trol, AK-Neo-Dex, Methadex, Dexacidin, NPD Ophthalmic Ointment, Neo-Decadron Cream, Neo-Dexair, Neo-Dex, Neo-Decadron Ocumeter, NEO TO GO!, Neo-Decadron, Spectrocin Plus, Lanabiotic, Mycitracin Plus Pain Reliever, Neosporin + Pain, Itch, Scar, Neosporin + Pain Relief Ointment, Neosporin + Pain Relief Neo To Go! First Aid Antibiotic, Poly Pred

Medically reviewed by Last updated on Aug 13, 2020.

Neomycin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although no information exists on the excretion of neomycin into milk, other aminoglycoside antibiotics are poorly excreted into breastmilk. Newborn infants apparently absorb small amounts of aminoglycosides, but serum levels are far below those attained when treating newborn infections and systemic effects of neomycin are unlikely. Older infants would be expected to absorb even less neomycin. Monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (e.g., thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis.

Oral, topical, ophthalmic or otic neomycin should result in very low levels in breastmilk and present negligible risk to the infant,[1][2] although topical application to the nipple may increase the risk of diarrhea in the infant. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[3]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Injection) Gentamicin, Kanamycin, Tobramycin; (Topical) Bacitracin, Clindamycin, Mupirocin, Polymyxin B


Niebyl JR. Use of antibiotics for ear, nose, and throat disorders in pregnancy and lactation. Am J Otolaryngol. 1992;13:187-92. [PubMed: 1503194]
Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24:167-97. [PubMed: 16677965]
Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. [PubMed: 14623482]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Anti-Infective Agents
  • Antibacterial Agents
  • Aminoglycosides
  • Dermatologic Agents

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Further information

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