Kanamycin use while Breastfeeding
Drugs containing Kanamycin: Kantrex
Medically reviewed by Drugs.com. Last updated on June 22, 2020.
Kanamycin Levels and Effects while Breastfeeding
Summary of Use during Lactation
If kanamycin is required by the mother, it is not a reason to discontinue breastfeeding. Kanamycin is poorly excreted into breastmilk. Newborn infants apparently absorb small amounts of other aminoglycosides, but serum levels with typical three times daily dosages are far below those attained when treating newborn infections and systemic effects of kanamycin are unlikely. Older infants would be expected to absorb even less kanamycin. Because there is little variability in the milk kanamycin levels during multiple daily dose regimens, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. Data are not available with single daily dose regimens. Monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (e.g., thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis.
Maternal Levels. After administration of a single 1 gram dose of kanamycin intramuscularly to several women (exact number not stated), average kanamycin milk levels were as follows: undetectable at 1 hour; 0.1 mg/L at 2 hours; 0.3 mg/L at 4 hours; and 0.5 mg/L at 6 hours after the dose.
In 15 women given kanamycin 500 mg intramuscularly three times daily, average kanamycin milk levels were as follows: undetectable at 0.5 hour; 2.57 mg/L at 1 hour; 2.51 mg/L at 2 hours; 2.12 mg/L at 4 hours; 2.06 mg/L at 6 hours; and 1.6 mg/L at 8 hours after the dose. Using data from this study, an exclusively breastfed infant would receive an estimated maximum daily dosage of 386 mcg/kg with this maternal dosage regimen.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Kanamycin was used as part of a six-drug regimen to treat a pregnant woman with multidrug-resistant tuberculosis during the first trimester of pregnancy and postpartum. The infant was breastfed (extent and duration not stated). At age 1.8 years, the child had failure to thrive, possibly due to tuberculosis contracted after birth, but was otherwise developing normally.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Chyo N, Sunada H, Nohara S. Clinical studies of kanamycin applied in the field of obstetrics and gynecology. Asian Med J. 1962;5:265-75.
Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5:57-60. [PubMed: 6743732]
Amiraslanova LA, Emel'ianova AI, Fursova SA, Rukhadze TG. [Various characteristics of the pharmacokinetics of ampicillin, kanamycin and cefuroxime in puerperants with endometritis]. Akush Ginekol (Mosk). 1985 Oct;(10):14-7. [PubMed: 2934996]
Drobac PC, del Castillo H, Sweetland A et al. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005;40:1689-92. [PubMed: 15889370]
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