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Kanamycin Side Effects

For the Consumer

Applies to kanamycin: injection solution

Along with its needed effects, kanamycin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking kanamycin:

Incidence not known
  • Agitation
  • black, tarry stools
  • bloody or cloudy urine
  • bluish lips or skin
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • coma
  • confusion
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • decreased urine output
  • depression
  • difficulty with breathing
  • difficulty with moving
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • feeling of constant movement of self or surroundings
  • feeling of fullness in the ears
  • fever
  • headache
  • irritability
  • lethargy
  • loss of balance
  • loss or change in hearing
  • muscle pain or stiffness
  • muscle twitching
  • nausea
  • not breathing
  • pain in lower back or side
  • pain in the joints
  • painful or difficult urination
  • pale skin
  • rapid weight gain
  • seizures
  • sensation of spinning
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • sweating
  • swelling of the face, ankles, or hands
  • swollen glands
  • thirst
  • trembling or shaking of the hands or feet
  • trouble with hearing
  • troubled breathing with exertion
  • uncontrolled eye movements
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of kanamycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Diarrhea
  • increased amount of gas
  • light-colored, frothy, or fatty-appearing stools
  • skin rash
  • sudden loss of weight
  • vomiting

For Healthcare Professionals

Applies to kanamycin: compounding powder, injectable solution, oral capsule

General

The major toxic effects associated with kanamycin therapy are ototoxicity and nephrotoxicity. It is considered one of the more toxic aminoglycosides.[Ref]

Nervous system

Nervous system side effects have included neuromuscular blockade, ototoxicity resulting in loss of vestibular function secondary to hair cell damage, and irreversible or partially reversible bilateral hearing loss. Nystagmus, vertigo, nausea, vomiting, and acute Meniere's syndrome are signs of vestibular dysfunction. Cochlear damage may be asymptomatic and may initially manifest as minor changes in audiometric test results at higher frequencies. Aminoglycosides have been associated with acute muscular paralysis, apnea, peripheral neuropathy and encephalopathy (numbness, paresthesia, muscle twitching, seizures), and myasthenia gravis-like syndrome. Neurotoxicity may occur after intrapleural, intraperitoneal, or parenteral administration. Patients with renal impairment may be at a higher risk.[Ref]

Renal

Renal side effects have included nephrotoxicity, albuminuria, presence of red and white cells and granular casts, azotemia, oliguria, and increased serum creatinine and BUN.[Ref]

Dermatologic

Dermatologic reactions have included skin rash.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and diarrhea.[Ref]

Local

Local reactions have included pain at the injection site after intramuscular injection.[Ref]

Metabolic

Metabolic side effects associated with prolonged kanamycin treatment have included malabsorption syndrome manifested as increased fecal fat, decreased serum carotene, and decreased xylose absorption.[Ref]

References

1. "Product Information. Kanamycin (kanamycin)." Raway Pharmacal Inc, Accord, NY.

2. Peloquin CA, Berning SE, Nitta AT, et al. "Aminoglycoside Toxicity: Daily versus Thrice-Weekly Dosing for Treatment of Mycobacterial Diseases." Clin Infect Dis 38 (2004): 1538-44

Some side effects of kanamycin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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