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Polymyxin B use while Breastfeeding

Medically reviewed by Last updated on Dec 9, 2022.

Drugs containing Polymyxin B: Neosporin, Polytrim, Cortisporin Otic, Maxitrol, Antibiotic Plus Pain Relief, Triple Antibiotic, Polysporin Ophthalmic, Pediotic, Antibiotic Ear, Terramycin with Polymyxin B Sulfate, Show all 94 »Neosporin Ophthalmic, Neosporin + Pain Relief Ointment, Polysporin First Aid Antibiotic Ointment, Septa, Polytracin Ophthalmic, Dexacine, Triple Antibiotic HC Ophthalmic Ointment, Cortisporin Ointment, Neosporin + Pain Relief Neo To Go! First Aid Antibiotic, Triple Antibiotic Plus, Neo-Poly-Dex, Methadex, Cortomycin, Otocort Sterile Suspension, Neosporin + Pain Relief Cream, Campho-Phenique Maximum Strength, Neo-Polycin HC, Cortomycin Eye Ointment, Neo-Poly-Bac, Ocu-Cort, Neotricin HC, Cortisporin Ophthalmic Ointment, ProCoMycin, First Aid Triple Antibiotic with Pain Reliever, Sx1 Medicated Post-Operative System, Neo-Polycin, Neocidin, Triple Antibiotic Ophthalmic Ointment, AK-Spore Ointment, Ocutricin, Neocin, Neosporin Ophthalmic Ointment, Ocu-Spore-B, Medi-Quik, Mycitracin Triple Antibiotic, Tribiotic Plus, Curad Triple Antibiotic, NEO TO GO!, Neosporin + Pain, Itch, Scar, Mycitracin Plus Pain Reliever, Lanabiotic, Spectrocin Plus, Neosporin + Burn Relief, Polycin, AK-Poly-Bac, Polycin-B, Simply Neosporin, Duospore, Polytracin, Betadine Antibiotic, Betadine Plus Antibiotic and Pain Reliever, Ophthocort, NPD Ophthalmic Ointment, Dexacidin, Dexasporin, AK-Trol, Ocu-Trol, Poly-Dex, Neocin-PG, Neoptic, Ocu-Spore-G, Neocidin Ophthalmic Solution, AK-Spore, Cortisporin Ophthalmic Suspension, Cortomycin Suspension, Neo/PolyB/HC, Casporyn HC, AK-Spore HC Otic Suspension, Drotic, Masporin Otic, Otocort Sterile Solution, Cortatrigen Modified, Otimar, UAD Otic, Cortatrigen, Cort-Biotic, Oti-Sone, Cortisporin Cream, Otobiotic, Statrol, Neosporin G U Irrigant, Antibiotic with Pramoxine, Poly Pred, Terak

Polymyxin B Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because it is poorly absorbed after topical application, polymyxin B is considered a low risk to the nursing infant.[1] Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[2]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Clindamycin, Mupirocin


Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24:167-97. [PubMed: 16677965]
Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. [PubMed: 14623482]

Substance Identification

Substance Name

Polymyxin B

CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Anti-Infective Agents
  • Antibacterial Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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