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Polymyxin B use while Breastfeeding

Drugs containing Polymyxin B: Maxitrol, Neosporin, Pediotic, Polysporin First Aid Antibiotic Ointment, Cortisporin Otic, Polytrim, Neosporin Ophthalmic, Triple Antibiotic HC Ophthalmic Ointment, Polysporin Ophthalmic, Antibiotic Ear, Show all 92 »Cortomycin, Cortisporin Ophthalmic Suspension, Terramycin with Polymyxin B Sulfate, Dexacidin, Neo-Polycin HC, Cortomycin Eye Ointment, Neo/PolyB/HC, Cortomycin Suspension, Neotricin HC, AK-Spore, Neocidin Ophthalmic Solution, Casporyn HC, Neoptic, Neocin-PG, Poly-Dex, Ocu-Trol, Dexacine, Ocu-Spore-G, AK-Spore HC Otic Suspension, Methadex, Cortisporin Cream, Terak, Poly Pred, Antibiotic with Pramoxine, Neosporin + Pain Relief Cream, Antibiotic Plus Pain Relief, Neosporin G U Irrigant, Statrol, Otobiotic, Oti-Sone, Drotic, Cort-Biotic, Cortatrigen, UAD Otic, Otocort Sterile Suspension, Otimar, Cortatrigen Modified, Otocort Sterile Solution, Masporin Otic, AK-Trol, NPD Ophthalmic Ointment, Dexasporin, Neocin, Tribiotic Plus, Mycitracin Triple Antibiotic, Medi-Quik, Septa, Ocu-Cort, Ocu-Spore-B, Neosporin Ophthalmic Ointment, Ocutricin, Curad Triple Antibiotic, AK-Spore Ointment, Triple Antibiotic Ophthalmic Ointment, Neocidin, Neo-Polycin, Sx1 Medicated Post-Operative System, First Aid Triple Antibiotic with Pain Reliever, ProCoMycin, Cortisporin Ointment, Triple Antibiotic, NEO TO GO!, Cortisporin Ophthalmic Ointment, Polycin-B, Neo-Poly-Dex, Ophthocort, Betadine Plus Antibiotic and Pain Reliever, Betadine Antibiotic, Polytracin, Duospore, Neo-Poly-Bac, AK-Poly-Bac, Neosporin + Pain Relief Neo To Go! First Aid Antibiotic, Polycin, Polytracin Ophthalmic, Triple Antibiotic Plus, Spectrocin Plus, Lanabiotic, Mycitracin Plus Pain Reliever, Neosporin + Pain, Itch, Scar, Neosporin + Pain Relief Ointment, Campho-Phenique Maximum Strength

Medically reviewed by Last updated on Mar 23, 2020.

Polymyxin B Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because it is poorly absorbed after topical application, polymyxin B is considered a low risk to the nursing infant.[1] Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[2]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Clindamycin, Mupirocin


Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24:167-97. [PubMed: 16677965]
Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. [PubMed: 14623482]

Substance Identification

Substance Name

Polymyxin B

CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Anti-Infective Agents
  • Antibacterial Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

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