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Polymyxin B use while Breastfeeding

Drugs containing Polymyxin B: Neosporin, Maxitrol, Cortisporin Otic, Polytrim, Triple Antibiotic, Pediotic, Antibiotic Plus Pain Relief, Neosporin Ophthalmic, Terramycin with Polymyxin B Sulfate, Antibiotic Ear, Show all 92 »Polysporin Ophthalmic, Polysporin First Aid Antibiotic Ointment, Neo-Poly-Dex, Cortisporin Ointment, Cortisporin Ophthalmic Suspension, Septa, Curad Triple Antibiotic, Neosporin + Pain Relief Ointment, Polytracin Ophthalmic, Antibiotic with Pramoxine, Neosporin + Pain, Itch, Scar, Lanabiotic, Methadex, Statrol, Campho-Phenique Maximum Strength, Neo-Polycin HC, Cortomycin Eye Ointment, Neo-Poly-Bac, Triple Antibiotic HC Ophthalmic Ointment, Ocu-Cort, Neotricin HC, Cortisporin Ophthalmic Ointment, ProCoMycin, First Aid Triple Antibiotic with Pain Reliever, Sx1 Medicated Post-Operative System, Neo-Polycin, Neocidin, Triple Antibiotic Ophthalmic Ointment, AK-Spore Ointment, Ocutricin, Neocin, Neosporin Ophthalmic Ointment, Ocu-Spore-B, Medi-Quik, Mycitracin Triple Antibiotic, Tribiotic Plus, NEO TO GO!, Neosporin + Pain Relief Neo To Go! First Aid Antibiotic, Mycitracin Plus Pain Reliever, Spectrocin Plus, Triple Antibiotic Plus, Polycin, AK-Poly-Bac, Polycin-B, Duospore, Polytracin, Betadine Antibiotic, Betadine Plus Antibiotic and Pain Reliever, Ophthocort, NPD Ophthalmic Ointment, Dexacidin, Dexasporin, AK-Trol, Dexacine, Ocu-Trol, Poly-Dex, Neocin-PG, Neoptic, Ocu-Spore-G, Neocidin Ophthalmic Solution, AK-Spore, Cortomycin Suspension, Neo/PolyB/HC, Cortomycin, Casporyn HC, AK-Spore HC Otic Suspension, Drotic, Masporin Otic, Otocort Sterile Solution, Cortatrigen Modified, Otimar, Otocort Sterile Suspension, UAD Otic, Cortatrigen, Cort-Biotic, Oti-Sone, Cortisporin Cream, Otobiotic, Neosporin G U Irrigant, Neosporin + Pain Relief Cream, Poly Pred, Terak

Medically reviewed by Last updated on Oct 6, 2021.

Polymyxin B Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because it is poorly absorbed after topical application, polymyxin B is considered a low risk to the nursing infant.[1] Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[2]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Clindamycin, Mupirocin


Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24:167-97. [PubMed: 16677965]
Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. [PubMed: 14623482]

Substance Identification

Substance Name

Polymyxin B

CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Anti-Infective Agents
  • Antibacterial Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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