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Mipomersen Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 17, 2023.

Applies to mipomersen: subcutaneous solution.

Warning

Mipomersen is available only from a certified pharmacy.

You should not use mipomersen if you have active liver disease or abnormal liver function tests. Tell your doctor right away if you have liver symptoms, such as vomiting, fever, stomach pain, itching, tiredness, dark urine, or jaundice (yellowing of the skin or eyes).

Mipomersen can cause your liver enzymes to get too high. Your blood will need to be tested often. Your treatments may be stopped based on the results of these tests.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using mipomersen and call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to mipomersen: subcutaneous solution.

Cardiovascular

Common (1% to 10%): Hypertension (7%), angina pectoris (4%), palpitations (3%)[Ref]

Dermatologic

Very common (10% or more): [All injection site reactions (84%)], erythema (59%), pain (56%), hematoma (32%), pruritus (29%), swelling (18%), discoloration (17%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (14%)

Common (1% to 10%): Vomiting (4%), abdominal pain (3%)[Ref]

Hepatic

Very common (10% or more): Alanine aminotransferase (ALT) increased (10%)

Common (1% to 10%): Hepatic steatosis (7%), aspartate aminotransferase (AST) increased (6%), liver function test abnormal (5%), hepatic enzyme increased (3%)[Ref]

Immunologic

Rare (less than 0.1%): One case of hypersensitivity with angioedema was reported[Ref]

Metabolic

Common (1% to 10%): Proteinuria (9%), peripheral edema (5%)[Ref]

Musculoskeletal

Common (1% to 10%): Pain in extremity (7%), musculoskeletal pain (4%)[Ref]

Nervous system

Very common (10% or more): Fatigue (15%), headache (12%)

Common (1% to 10%): Pyrexia (8%), chills (6%)[Ref]

Oncologic

Common (1% to 10%): Neoplasms [benign and malignant] (4%)[Ref]

Psychiatric

Common (1% to 10%): Insomnia (3%)[Ref]

Renal

Rare (less than 0.1%): One case of glomerular nephritis was reported[Ref]

References

1. Product Information. Kynamro (mipomersen). Genzyme Corporation. 2013.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.