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Maxzide Side Effects

Generic Name: hydrochlorothiazide / triamterene

Note: This page contains information about the side effects of hydrochlorothiazide / triamterene. Some of the dosage forms included on this document may not apply to the brand name Maxzide.

For the Consumer

Applies to hydrochlorothiazide / triamterene: oral capsule, oral tablet

In addition to its needed effects, some unwanted effects may be caused by hydrochlorothiazide / triamterene. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking hydrochlorothiazide / triamterene:

Incidence not known:
  • Abdominal or stomach pain
  • agitation
  • back or leg pains
  • black, tarry stools
  • bleeding gums
  • blisters, hives, or itching
  • bloating
  • blood in the urine or stools
  • blue lips and fingernails
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clay-colored stools
  • cloudy urine
  • cold sweats
  • coma
  • confusion
  • constipation
  • convulsions
  • cough or hoarseness
  • coughing that sometimes produces a pink frothy sputum
  • dark urine
  • decreased urine output
  • depression
  • difficult, fast, noisy breathing, sometimes with wheezing
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • drowsiness
  • dry mouth
  • fast, slow, or irregular heartbeat
  • fever with or without chills
  • flushed, dry skin
  • fruit-like breath odor
  • general body swelling
  • general feeling of discomfort, illness, or weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • hostility
  • incoherent speech
  • increased hunger
  • increased sweating
  • increased thirst
  • increased urination
  • indigestion
  • irritability
  • joint pain, stiffness, or swelling
  • lethargy
  • loss of appetite
  • loss of consciousness
  • lower back or side pain
  • metallic taste
  • mood changes
  • muscle pain, cramps, weakness, or twitching
  • nausea or vomiting
  • nervousness
  • nosebleeds
  • numbness or tingling in the hands, feet, or lips
  • pain in the groin or genitals
  • painful or difficult urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red or purple spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • seizures
  • sharp back pain just below the ribs
  • shortness of breath
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomachache
  • stupor
  • sugar in the urine
  • swelling of the face, ankles, hands, feet, or lower legs
  • swollen or painful glands
  • thickening of bronchial secretions
  • tightness in the chest
  • troubled breathing
  • unexplained weight loss
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • weak pulse
  • weakness or heaviness of the legs
  • wheezing
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking hydrochlorothiazide / triamterene, get emergency help immediately:

Symptoms of overdose:
  • Face is warm or hot to touch
  • frequent urination
  • increased volume of pale, dilute urine
  • loss of strength or energy
  • pain or weakness in the hands or feet
  • redness to face
  • reflexes are unusually strong
  • trembling

Minor Side Effects

Some of the side effects that can occur with hydrochlorothiazide / triamterene may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Decreased interest in sexual intercourse
  • feeling of constant movement of self or surroundings
  • inability to have or keep an erection
  • increased sensitivity of the skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • redness or other discoloration of the skin
  • sensation of spinning
  • severe sunburn
  • welts

For Healthcare Professionals

Applies to hydrochlorothiazide / triamterene: oral capsule, oral tablet


Frequency not reported: Diabetes mellitus, hyperkalemia, hyperglycemia, hyperuricemia, hypokalemia, hyponatremia, acidosis, hypochloremia, thirst, minor serum electrolyte changes, marked fluctuations in serum potassium levels[Ref]


Frequency not reported: Pancreatitis, nausea, vomiting, diarrhea, constipation, abdominal pain, dry mouth, sialadenitis[Ref]


Frequency not reported: Acute renal failure, interstitial nephritis, renal stones composed primarily of triamterene, BUN elevated, serum creatinine elevated[Ref]

There is no evidence that stone formation is increased in patients taking triamterene containing drugs.[Ref]


Frequency not reported: Rash, urticaria, photosensitivity, purpura[Ref]


Frequency not reported: Arrhythmias, postural hypotension, undesirable decrease in blood pressure[Ref]


Frequency not reported: Glycosuria, abnormal urinary sediment, impotence[Ref]


Frequency not reported: Leukopenia, thrombocytopenia, megaloblastic anemia

Frequency not reported: Thrombocytopenic purpura, megaloblastic anemia[Ref]


Frequency not reported: Jaundice, liver enzyme abnormalities[Ref]


Frequency not reported: Muscle cramps, systemic lupus erythematosus[Ref]

Nervous system

Frequency not reported: Dizziness, headache[Ref]


Frequency not reported: Weakness, fatigue[Ref]


Frequency not reported: Anaphylaxis[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Maxzide (hydrochlorothiazide-triamterene)." Lederle Laboratories, Wayne, NJ.

Not all side effects for Maxzide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.