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Maxipime Side Effects

Generic name: cefepime

Medically reviewed by Last updated on Sep 5, 2023.

Note: This document contains side effect information about cefepime. Some dosage forms listed on this page may not apply to the brand name Maxipime.

Applies to cefepime: injection powder for solution.

Serious side effects of Maxipime

Along with its needed effects, cefepime (the active ingredient contained in Maxipime) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cefepime:

More common

Less common


Incidence not known

Other side effects of Maxipime

Some side effects of cefepime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


For Healthcare Professionals

Applies to cefepime: injectable powder for injection, intravenous powder for injection, intravenous solution.


The most commonly reported side effects included positive Coombs' Test (without hemolysis), localized reactions, increased ALT, and diarrhea.[Ref]


Very common (10% or more): Positive Coombs' Test without hemolysis (up to 18.7%)

Common (1% to 10%): Abnormal partial thromboplastin time (PTT), abnormal prothrombin time (PT), anemia, eosinophilia, PT prolonged, PTT prolonged

Uncommon (0.1% to 1%): Decreased hematocrit, decreased neutrophils/neutropenia, decreased platelets/thrombocytopenia/transient thrombocytopenia, decreased white blood cell counts/leukopenia/transient leukopenia

Rare (0.01% to 0.1%): Transient neutropenia

Frequency not reported: Agranulocytosis, aplastic anemia, hemolytic anemia

Postmarketing reports: Pancytopenia[Ref]

Agranulocytosis, aplastic anemia, hemolytic anemia, neutropenia, pancytopenia, thrombocytopenia, and transient leukopenia were reported with cephalosporin use.[Ref]


Liver dysfunction and cholestasis were reported with cephalosporin use.[Ref]

Common (1% to 10%): Alkaline phosphatase increased, blood bilirubin increased, increased ALT, increased AST, increased total bilirubin

Postmarketing reports: Cholestasis, liver dysfunction[Ref]


Local reactions included inflammation, pain, phlebitis, and rash, and occurred irrespective to this drug in patients who received IV infusion.[Ref]

Common (1% to 10%): Infusion site reactions/local reactions, injection site inflammation, injection site pain

Uncommon (0.1% to 1%): Infusion site inflammation[Ref]


Common (1% to 10%): Diarrhea, nausea, vomiting

Uncommon (0.1% to 1%): Colitis, oral candidiasis, oral moniliasis, pseudomembranous colitis

Rare (0.01% to 0.1%): Abdominal pain, constipation

Frequency not reported: Clostridium difficile-associated diarrhea, gastrointestinal disorder[Ref]

Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including diarrhea, nausea, and vomiting.[Ref]


Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including rash and pruritus.

The most frequently reported side effect in pediatric patient was rash.

Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis were reported with cephalosporin use.[Ref]

Common (1% to 10%): Pruritus, rash/skin rash

Uncommon (0.1% to 1%): Erythema, urticaria

Frequency not reported: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]


Common (1% to 10%): Fever/pyrexia

Uncommon (0.1% to 1%): Inflammation, pain

Rare (0.01% to 0.1%): Chills[Ref]

Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including fever.[Ref]


Common (1% to 10%): Phlebitis/infusion site phlebitis

Rare (0.01% to 0.1%): Vasodilation

Frequency not reported: Hemorrhage[Ref]

Hemorrhage was reported with cephalosporin use.[Ref]


Common (1% to 10%): Decreased phosphorus

Uncommon (0.1% to 1%): Decreased calcium, hypocalcemia, increased calcium, increased phosphorus, increased potassium

Frequency not reported: False positive glycosuria[Ref]

Hypocalcemia occurred more frequently in older patients.

False positive glycosuria was reported with cephalosporin use.[Ref]

Nervous system

Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including headache.

Encephalopathy included coma, confusion, consciousness disorder, hallucinations, and stupor.

Coma, consciousness disorder, convulsions, encephalopathy, myoclonus, and stupor were reported with cephalosporin use.[Ref]

Common (1% to 10%): Headache

Rare (0.01% to 0.1%): Convulsions, dizziness, dysgeusia, paresthesia, taste perversion

Very rare (less than 0.01%): Seizures

Frequency not reported: Altered state of consciousness/consciousness disorder, coma, encephalopathy, myoclonus, neurotoxicity, stupor

Postmarketing reports: Aphasia, nonconvulsive status epilepticus[Ref]


Rare (0.01% to 0.1%): Dyspnea[Ref]


Uncommon (0.1% to 1%): Blood creatinine increased/increased creatinine, blood urea increased/increased blood urea nitrogen (BUN), transient increase in serum creatinine, transient increase in serum urea, transient uremia

Frequency not reported: Renal dysfunction, renal failure, toxic nephropathy[Ref]

Renal failure and toxic nephropathy were reported with cephalosporin use.[Ref]


Uncommon (0.1% to 1%): Vaginal infection, vaginitis

Rare (0.01% to 0.1%): Genital pruritus[Ref]


Rare (0.01% to 0.1%): Anaphylactic reaction, angioedema

Frequency not reported: Anaphylactic shock, anaphylaxis, hypersensitivity reactions[Ref]

Anaphylactic shock and anaphylaxis were reported with cephalosporin use.[Ref]


Rare (0.01% to 0.1%): Candidiasis, unspecified moniliasis[Ref]


Frequency not reported: Confusion/state of confusion, hallucinations[Ref]

Confusion and hallucinations were reported with cephalosporin use.[Ref]


1. (2001) "Product Information. Maxipime (cefepime)." Bristol-Myers Squibb

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.