Margetuximab Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 20, 2024.

Applies to margetuximab: intravenous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for at least 4 months after the last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

This medicine may cause heart problems (eg, left ventricular dysfunction). Check with your doctor right away if you have chest pain, decreased urine output, dilated neck veins, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, tightness in the chest, trouble breathing, unusual tiredness or weakness, or weight gain.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of margetuximab

Along with its needed effects, margetuximab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking margetuximab:

Other side effects of margetuximab

Some side effects of margetuximab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to margetuximab: intravenous solution.

General adverse events

• Very common (10% or more): Fatigue/Asthenia (57%), pyrexia (19%), infusion related reaction (13%)
• Common (1% to 10%): Fatal adverse reactions (1.1%)^[Ref]

Immunologic

• Common (1% to 10%): Immunogenicity (1.7%)^[Ref]

Musculoskeletal

• Very common (10% or more): Myalgia (14%), arthralgia (14%), extremity pain (11%)^[Ref]

Hepatic

• Very common (10% or more): Increased serum alanine aminotransferase (32%), increased serum aspartate aminotransferase (23%), increased serum alkaline phosphatase (21%)^[Ref]

Respiratory

• Very common (10% or more): Cough (14%), dyspnea (13%)
• Uncommon (0.1% to 1%): Aspiration pneumonia (0.4%), viral pneumonia(0.8%)^[Ref]

Hematologic

• Very common (10% or more): Decreased hemoglobin (52%;), decreased leukocytes (40%), decreased lymphocytopenia (31%), increased INR (24%;), increased aPTT (32%)
• Common (1% to 10%): Febrile neutropenia (1.5%), neutropenia/neutrophil count decrease (1.5%)^[Ref]

Nervous system

• Very common (10% or more): Headache (19%), peripheral neuropathy (16%)
• Common (1% to 10%): Dizziness (10%), insomnia (6%)^[Ref]

Renal

• Very common (10% or more): Increased serum creatinine (68%)^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension (5%), left ventricular dysfunction (1.9%), syncope (1.5%)^[Ref]

Dermatologic

• Very common (10% or more): Alopecia (18%), palmar-plantar erythrodysesthesia (13%)
• Common (1% to 10%): Skin rash (6%)^[Ref]

Endocrine

• Common (1% to 10%): Decreased weight (6%), increased serum lipase (30%),^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (17%), constipation (19%), increased serum lipase (30%), decreased appetite (14%), nausea (33%), vomiting (21%), diarrhea (25%)
• Common (1% to 10%): Dysgeusia (6%), stomatitis (10%)^[Ref]

See also:

Further information

Margetuximab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer