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Margetuximab Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 20, 2024.

Applies to margetuximab: intravenous solution.

Important warnings This medicine can cause some serious health issues

Intravenous route (solution)

Warning: Left Ventricular Dysfunction and Embryo-fetal Toxicity. Left Ventricular Dysfunction: Margetuximab-cmkb may lead to reductions in left ventricular ejection fraction (LVEF).

Evaluate cardiac function prior to and during treatment.

Discontinue margetuximab-cmkb treatment for a confirmed clinically significant decrease in left ventricular function.Embryo-fetal Toxicity: Exposure to margetuximab-cmkb during pregnancy can cause embryo-fetal harm.

Advise patients of the risk and need for effective contraception.

Serious side effects of margetuximab

Along with its needed effects, margetuximab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking margetuximab:

More common side effects

  • back pain
  • chest pain or tightness
  • chills
  • cough
  • decreased urine output
  • difficulty in moving
  • dilated neck veins
  • fever
  • flushing
  • headache
  • irregular breathing
  • irregular heartbeat
  • muscle aches, cramps, pain, or stiffness
  • nausea and vomiting
  • pain in the joints
  • redness, swelling, pain of the skin
  • scaling of the skin on the hands and feet
  • swelling of the face, fingers, feet, or lower legs
  • swollen joints
  • tingling of the hands and feet
  • trouble breathing
  • ulceration of the skin
  • unusual tiredness or weakness
  • weakness
  • weight gain

Other side effects of margetuximab

Some side effects of margetuximab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • arm or leg pain
  • burning, numbness, tingling, or painful sensations
  • constipation
  • decreased appetite
  • diarrhea
  • hair loss, thinning of hair
  • stomach pain
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For healthcare professionals

Applies to margetuximab: intravenous solution.

General adverse events

Immunologic

Musculoskeletal

Hepatic

Respiratory

Hematologic

Nervous system

Renal

Cardiovascular

Dermatologic

Endocrine

Gastrointestinal

References

1. (2021) "Product Information. Margenza (margetuximab)." Almirall

Further information

Margetuximab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.