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Maldemar Side Effects

Generic Name: scopolamine

Note: This document contains side effect information about scopolamine. Some of the dosage forms listed on this page may not apply to the brand name Maldemar.

For the Consumer

Applies to scopolamine: transdermal patch extended release

Along with its needed effects, scopolamine (the active ingredient contained in Maldemar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking scopolamine:

Incidence not known
  • Blurred vision
  • chest pain or discomfort
  • difficulty with urinating
  • dilation of the pupils
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • eye pain
  • flushing or redness of the skin
  • mood or mental changes
  • muscle weakness
  • nausea or vomiting
  • rash
  • redness of the white part of the eyes
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • shortness of breath
  • slow or irregular heartbeat
  • sweating
  • unusual tiredness
  • unusually warm skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking scopolamine:

Symptoms of overdose
  • Anxiety
  • blurred or loss of vision
  • change in consciousness
  • decrease in frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • disturbed color perception
  • double vision
  • dry mouth
  • dry, flushed skin
  • fast, pounding, or irregular heartbeat or pulse
  • halos around lights
  • headache
  • hyperventilation
  • irritability
  • loss of consciousness
  • nervousness
  • night blindness
  • overbright appearance of lights
  • painful urination
  • pounding in the ears
  • seizures
  • shaking
  • sleepiness
  • trouble with sleeping
  • tunnel vision
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

For Healthcare Professionals

Applies to scopolamine: compounding powder, injectable solution, oral tablet, transdermal film extended release


Common (1% to 10%): Tachycardia
Frequency not reported: Blood pressure decreased, flushing, bradycardia, palpitations, arrhythmias, fatal acute myocardial infarction, fatal cardiac arrest[Ref]


Very common (10% or more): Dry mouth (29%)
Frequency not reported: Vomiting[Ref]

Nervous system

Recurrent classic migraine attacks developed in a 20-year-old naval crew member who had been treated continuously with transdermal scopolamine (the active ingredient contained in Maldemar) for 5 months. The initial attack occurred within 24 hours of diagnosis of scopolamine intoxication. The patient had no self or family history of migraines. The attacks, presenting with prodrome and aura, followed by severe throbbing left headache, nausea, photophobia and sonophobia lasting 6 to 8 hours, recurred every 10 to 14 days for more than a year. Common triggers of migraines and other precipitating factors could not be identified in this case.[Ref]

Very common (10% or more): Dizziness (12.4%), somnolence
Rare (less than 0.1%): Memory impairment, disturbance in attention
Postmarketing reports: Headache, amnesia, coordination abnormalities, speech disorder, vertigo[Ref]


Very common (10% or more): Disturbances of visual accommodation (cycloplegia, including blurred vision, myopia, and mydriasis)
Common (1% to 10%): Visual impairment, eyelid irritation
Very rare (less than 0.01%): Pupillary dilatation which may precipitate acute glaucoma (particularly narrow angle glaucoma)
Frequency not reported: Photophobia, increased ocular pressure
Postmarketing reports: Dry eyes, eye pruritic, angle closure glaucoma, amblyopia, eyelid irritation[Ref]


Common (1% to 10%): Urinary retention
Postmarketing reports: Dysuria[Ref]


Common (1% to 10%): Agitation, confusion, hallucinations
Rare (less than 0.1%): Disorientation, restlessness, visual hallucinations
Postmarketing reports: Acute psychosis[Ref]


Frequency not reported: Allergic reaction, anaphylactic reaction, hypersensitivity reactions, fatal anaphylactic shock[Ref]


Common (1% to 10%): Skin irritation
Very rare (less than 0.01%): Generalized rash
Frequency not reported: Dyshidrosis, skin dryness, rash
Postmarketing reports: Erythema[Ref]


Frequency not reported: Injection site pain
Postmarketing reports: Application site burning (patch)[Ref]


Common (1% to 10%): Pharyngitis[Ref]


Frequency not reported: Hyperthermia at high temperatures due to decreased sweating[Ref]


Frequency not reported: Thirst[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Therapeutic Goods Administration "Medicines Safety Update, Volume 8 Number 4, August-September 2017 Available from: URL:" ([2017, Sep 13]):

4. Medicines and Healthcare products Regulatory Agency "Hyoscine butylbromide (Buscopan) injection: risk of serious adverse effects in patients with underlying cardiac disease. Available from: URL:" ([2017, Apr 03]):

5. "Product Information. Transderm-Scop (scopolamine (hyoscine (scopolamine)))." Sandoz Inc, Broomfield, CO.

6. "Product Information. Scopolamine (scopolamine (hyoscine (scopolamine)))." Perrigo, L. Company, Allegan, MI.

Some side effects of Maldemar may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.