M-Prednisolone Side Effects

Generic name: methylprednisolone

Medically reviewed by Drugs.com. Last updated on Jan 10, 2024.

Note: This document provides detailed information about M-Prednisolone Side Effects associated with methylprednisolone. Some dosage forms listed on this page may not apply specifically to the brand name M-Prednisolone.

Applies to methylprednisolone: injection powder for solution, injection solution, injection suspension.

Other dosage forms:

• oral tablet

Precautions

It is very important that your doctor check you or your child's progress at regular visits to make sure this medicine is working properly and to decide if you should continue to receive it. Blood or urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

If you are receiving this medicine for a long time, the skin at the injection site may become slightly depressed or wrinkled. Talk to your doctor if you notice any of these changes at the injection site: depressed or indented skin, or pain, redness, or sloughing (peeling) of the skin.

This medicine may cause an allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving this medicine.

If you are receiving this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. Your dose of this medicine might need to be changed for a short time while you have extra stress.

Receiving too much of this medicine or receiving it for a long time may increase your and your child's risk of having adrenal gland problems. Talk to your doctor right away if you or your child have more than one of these symptoms while receiving this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.

This medicine may cause you or your child to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you or your child are exposed to chickenpox or measles, tell your doctor right away. If you or your child start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away.

Tell your doctor if you or your child have recently spent time in a tropical climate or have unexplained diarrhea before receiving this medicine.

While you are being treated with methylprednisolone (the active ingredient contained in M-Prednisolone) injection, do not have any immunizations (vaccines) without your doctor's approval. Methylprednisolone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor.

Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine might cause thinning of the bones (osteoporosis) or slow growth in children if received for a long time. Tell your doctor if you have any bone pain or if you have an increased risk for osteoporosis. If your child is receiving this medicine, tell the doctor if you think your child is not growing properly.

This medicine may cause changes in mood or behavior for some patients. Tell your doctor right away if you or your child have depression, mood swings, a false or unusual sense of well-being, trouble with sleeping, or personality changes while receiving this medicine.

Make sure any doctor or dentist who treats you knows that you are receiving this medicine. This medicine may affect the results of certain skin tests.

Do not stop receiving this medicine suddenly without checking first with your doctor. Your doctor may want you or your child to gradually reduce the amount you are receiving before stopping it completely.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of M-Prednisolone

Along with its needed effects, methylprednisolone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking methylprednisolone:

Other side effects of M-Prednisolone

Some side effects of methylprednisolone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

See also:

For healthcare professionals

Applies to methylprednisolone: compounding powder, injectable powder for injection, injectable suspension, oral tablet.

General adverse events

The most commonly occurring side effects have included fluid retention, alteration in glucose tolerance, increased blood pressure, behavioral and mood changes, increased appetite, and weight gain; the incidence generally correlates with dosage, timing of administration, and duration of treatment.^[Ref]

Hypersensitivity

• Frequency not reported: Allergic or hypersensitivity reactions; anaphylactoid reaction, anaphylaxis, angioedema, bronchospasm^[Ref]

A European review describes cases of allergic reactions, including bronchospasm and anaphylaxis, in patients allergic to cows milk proteins receiving injectable methylprednisolone (the active ingredient contained in M-Prednisolone) products containing lactose of bovine origin. In most cases, the patients were younger than 12 years old and had childhood asthma. In some cases, the reaction was mistaken as lack of efficacy, and additional doses of were give with subsequent worsening of the patients condition. The European Union has recommended lactose-containing methylprednisolone products be reformulated to remove any trace of milk proteins by 2019.^[Ref]

Cardiovascular

• Frequency not reported: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis, edema, hypotension^[Ref]

Endocrine

• Frequency not reported: Cushingoid state, hirsutism, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), moon face^[Ref]

Gastrointestinal

• Frequency not reported: Abdominal distention, nausea, pancreatitis, peptic ulcer, perforation of the small and large intestine, ulcerative esophagitis, gastric hemorrhage, vomiting, abdominal pain, diarrhea, dyspepsia, nausea^[Ref]

Hepatic

• Frequency not reported: Hepatomegaly, elevation in liver enzymes, toxic hepatitis^[Ref]

Reversible transaminase elevations (AST, ALT) have been observed following corticosteroid therapy. These changes have generally been small and not associated with any clinical syndrome. Toxic hepatitis has been reported with high doses of cyclically pulsed IV therapy, onset has been several weeks or longer. Resolution has been reported with discontinuation; however, recurrence has been reported with rechallenge.^[Ref]

Metabolic

• Frequency not reported: Decreased carbohydrate and glucose tolerance, manifestations of latent diabetes, hypokalemic alkalosis, potassium loss, sodium retention, increased appetite, negative nitrogen balance due to protein catabolism, weight gain, metabolic acidosis, dyslipidemia, lipomatosis^[Ref]

Musculoskeletal

• Frequency not reported: Suppression of growth in pediatric patients, aseptic necrosis of femoral and humeral heads, calcinosis, Charcot-like atrophy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, postinjection flare, steroid myopathy, tendon rupture, particularly of the Achilles tendon, vertebral compression fractures, myalgia, muscle atrophy, osteonecrosis, neuropathic arthralgia, growth retardation^[Ref]

Hematologic

• Frequency not reported: Leucocytosis^[Ref]

Immunologic

• Frequency not reported: Opportunistic infection^[Ref]

Ocular

• Frequency not reported: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, blindness, chorioretinopathy^[Ref]

Blindness has been reported with corticosteroid injection to scalp, tonsillar fauces, sphenopalatine ganglion.^[Ref]

Psychiatric

• Frequency not reported: Depression, emotional instability, euphoria, insomnia, mood swings, personality changes, psychic disorders, confusional states, anxiety, abnormal behavior, irritability^[Ref]

Dermatologic

• Frequency not reported: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymosis, petechiae, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria, hypertrichosis, angioedema, skin atrophy, hyperhidrosis, pruritus^[Ref]

Local

• Frequency not reported: Injection site infections, injection site reactions^[Ref]

Nervous system

• Frequency not reported: Convulsions, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, neuritis, neuropathy, paresthesia, amnesia, dizziness^[Ref]

Other

• Frequency not reported: Vertigo, abnormal fat deposits, malaise, sterile abscess, impaired healing, fatigue^[Ref]

Oncologic

• Frequency not reported: Kaposi's sarcoma^[Ref]

Respiratory

• Frequency not reported: Pulmonary edema, pulmonary embolism, hiccups^[Ref]

Genitourinary

• Frequency not reported: Menstrual irregularities, increased or decreased motility and number of spermatozoa, increased urine calcium, glycosuria^[Ref]

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Further information

M-Prednisolone side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer