Lurbinectedin Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 21, 2022.
Applies to lurbinectedin: intravenous powder for solution.
Serious side effects of Lurbinectedin
Along with its needed effects, lurbinectedin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking lurbinectedin:
- Black, tarry stools
- bleeding gums
- bloody urine
- bone, joint, or muscle pain
- chest pain or tightness
- dark urine
- difficult or labored breathing
- general feeling of discomfort or illness
- loss of appetite
- lower back or side pain
- painful or difficult urination
- pale skin
- pale stools
- pinpoint red spots on the skin
- sore throat
- stomach pain or tenderness
- thickening of bronchial secretions
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes or skin
- Swelling of the feet or lower legs
Incidence not known
- Muscle cramps, spasms, or stiffness
- pain, discomfort, itching, redness, or swelling at the injection site
Other side effects of Lurbinectedin
Some side effects of lurbinectedin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Burning, numbness, tingling, or painful sensations
- change in or loss of taste
- unsteadiness or awkwardness
For Healthcare Professionals
Applies to lurbinectedin: intravenous powder for injection.
Very common (10% or more): Leucocytes decreased (79%), lymphocytes decreased (79%), hemoglobin decreased (74%), neutrophils decreased (71%),
Common (1% to 10%): Febrile neutropenia[Ref]
Very common (10% or more): Alanine aminotransferase increased (66%), aspartate aminotransferase increased (26%)
Common (1% to 10%): Grade 3 elevations of ALT and AST, Grade 4 elevations of ALT and AST[Ref]
Very common (10% or more): Dyspnea (31%), cough (e.g., cough, productive cough) (20%), respiratory infection (e.g., upper respiratory tract infection, viral upper respiratory tract infection, respiratory tract infection, bronchitis) (18%), pneumonia (10%), lung infection (10%)
Common (1% to 10%): Pneumonitis[Ref]
The most common adverse reactions, including laboratory abnormalities (20% or more) were leukopenia, lymphopenia, fatigue, anemia, neutropenia, increased creatinine, increased alanine aminotransferase, increased glucose, thrombocytopenia, nausea, decreased appetite, musculoskeletal pain, decreased albumin, constipation, dyspnea, decreased sodium, increased aspartate aminotransferase, vomiting, cough, decreased magnesium, and diarrhea.[Ref]
Common (1% to 10%): Dysgeusia[Ref]
Very common (10% or more): Creatinine increased (69%)[Ref]
Very common (10% or more): Chest pain (10%)[Ref]
More about lurbinectedin
Related treatment guides
1. "Product Information. Zepzelca (lurbinectedin)." Jazz Pharmaceuticals (2020):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.