Skip to Content

Levo-Dromoran Side Effects

Generic Name: levorphanol

Note: This document contains side effect information about levorphanol. Some of the dosage forms listed on this page may not apply to the brand name Levo-Dromoran.

For the Consumer

Applies to levorphanol: oral tablet

Along with its needed effects, levorphanol (the active ingredient contained in Levo-Dromoran) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levorphanol:

Incidence Not Known

  • Agitation
  • attempts at killing oneself
  • bluish lips or skin
  • blurred vision
  • change in consciousness
  • cold, clammy skin
  • confusion
  • decrease in the frequency of urination
  • decrease in urine volume
  • decreased urine output
  • depression
  • difficulty in passing urine (dribbling)
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extra heartbeats
  • extremely shallow or slow breathing
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • fast, weak pulse
  • hostility
  • lethargy
  • lightheadedness
  • loss of consciousness
  • muscle twitching
  • no blood pressure or pulse
  • not breathing
  • painful urination
  • rapid weight gain
  • seizures
  • stopping of the heart
  • stupor
  • sweating
  • swelling of the face, ankles, or hands
  • unconsciousness
  • unusual tiredness or weakness
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking levorphanol:

Symptoms of Overdose

  • Chest pain or discomfort
  • constricted, pinpoint, or small pupils (black part of the eye)
  • decreased awareness or responsiveness
  • difficult or troubled breathing
  • difficulty with sleeping
  • dilated neck veins
  • disorientation
  • drowsiness to profound coma
  • extreme fatigue
  • hallucination
  • headache
  • irregular, fast or slow, or shallow breathing
  • no muscle tone or movement
  • not breathing
  • pale or blue lips, fingernails, or skin
  • shortness of breath
  • sleepiness or unusual drowsiness
  • swelling of the face, fingers, feet, or lower legs
  • weight gain

Some side effects of levorphanol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence Not Known

  • Abnormal dreams
  • absence of or decrease in body movement
  • acid or sour stomach
  • belching
  • change in personality
  • changes in vision
  • delusions
  • dementia
  • discouragement
  • double vision
  • dry mouth
  • feeling sad or empty
  • heartburn
  • hives or welts
  • increase in body movements
  • indigestion
  • irritability
  • itching
  • lack of appetite
  • loss of interest or pleasure
  • loss of memory
  • nausea
  • nervousness
  • problems with memory
  • redness of the skin
  • seeing double
  • skin rash
  • stomach discomfort, upset, or pain
  • sweating
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • upper abdominal or stomach pain
  • vomiting

For Healthcare Professionals

Applies to levorphanol: compounding powder, injectable solution, oral tablet

General

The adverse effects of this drug are generally similar to the adverse effects observed with other narcotic analgesics including nausea, vomiting, altered mood and mentations, pruritus, flushing, difficulties in urination, constipation, and biliary spasm.[Ref]

Respiratory

Frequency not reported: Apnea, cyanosis, hypoventilation

Nervous system

Frequency not reported: Coma, convulsions, dizziness, lethargy, hypokinesia, dyskinesia, hyperkinesia, CNS stimulation

Postmarketing reports: Serotonin syndrome[Ref]

Cases of serotonin syndrome have been reported with concomitant use of serotonergic drugs.[Ref]

Hypersensitivity

Postmarketing reports: Anaphylaxis

Anaphylaxis has been reported with ingredients contained in the levorphanol tablets.

Cardiovascular

Frequency not reported: Cardiac arrest, shock, hypotension, arrhythmias including bradycardia and tachycardia, palpitations, extra-systoles[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, constipation, dyspepsia, biliary tract spasm, abdominal pain, dry mouth[Ref]

Genitourinary

Frequency not reported: Urinary retention, difficulty urinating[Ref]

Dermatologic

Frequency not reported: Pruritus, urticaria, rash, sweating[Ref]

Psychiatric

Frequency not reported: Suicide attempt, depression, confusion, abnormal dreams, abnormal thinking, nervousness, drug withdrawal, personality disorder, amnesia, insomnia

Renal

Frequency not reported: Kidney failure

Endocrine

Postmarketing reports: Adrenal insufficiency, androgen deficiency

Cases of adrenal insufficiency and androgen deficiency have been reported with opioid use. Adrenal insufficiency has more often been reported following use of greater than 1 month. Androgen deficiency has occurred with chronic opioid use.

Ocular

Frequency not reported: Abnormal vision, pupillary disorder, diplopia

References

1. "Multum Information Services, Inc. Expert Review Panel"

2. Covington EC, Gonsalves-Ebrahim L, Currie KO, et al "Severe respiratory depression from patient-controlled analgesia in renal failure." Psychosomatics 30 (1989): 226-8

3. Bellville JW, Forrest WH, Elashoff J, Laska E "Evaluating side effects of analgesics in a cooperative clinical study." Clin Pharmacol Ther 9 (1968): 303-13

4. "Product Information. Levo-Dromoran (levorphanol)." Roche Laboratories, Nutley, NJ.

5. D'Souza M "Unusual reaction to morphine." Lancet 07/11/87 (1987): 98

6. White MJ, Berghausen EJ, Dumont SW, et al "Side effects during continuous epidural infusion of morphine and fentanyl." Can J Anaesth 39 (1992): 576-82

7. Petersen TK, Husted SE, Rybro L, et al "Urinary retention during I.M. and extradural morphine analgesia." Br J Anaesth 54 (1982): 1175-8

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Hide