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Levo-Dromoran Side Effects

Generic Name: levorphanol

Note: This page contains information about the side effects of levorphanol. Some of the dosage forms included on this document may not apply to the brand name Levo-Dromoran.

For the Consumer

Applies to levorphanol: oral tablet

In addition to its needed effects, some unwanted effects may be caused by levorphanol (the active ingredient contained in Levo-Dromoran). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking levorphanol:

Incidence not known:
  • Agitation
  • attempts at killing oneself
  • bluish lips or skin
  • blurred vision
  • change in consciousness
  • cold, clammy skin
  • confusion
  • decrease in the frequency of urination
  • decrease in urine volume
  • decreased urine output
  • depression
  • difficulty in passing urine (dribbling)
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extra heartbeats
  • extremely shallow or slow breathing
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • fast, weak pulse
  • hostility
  • lethargy
  • lightheadedness
  • loss of consciousness
  • muscle twitching
  • no blood pressure or pulse
  • not breathing
  • painful urination
  • rapid weight gain
  • seizures
  • stopping of the heart
  • stupor
  • sweating
  • swelling of the face, ankles, or hands
  • unconsciousness
  • unusual tiredness or weakness
  • wheezing

If any of the following symptoms of overdose occur while taking levorphanol, get emergency help immediately:

Symptoms of overdose:
  • Chest pain or discomfort
  • constricted, pinpoint, or small pupils (black part of the eye)
  • decreased awareness or responsiveness
  • difficult or troubled breathing
  • difficulty with sleeping
  • dilated neck veins
  • disorientation
  • drowsiness to profound coma
  • extreme fatigue
  • hallucination
  • headache
  • irregular, fast or slow, or shallow breathing
  • no muscle tone or movement
  • not breathing
  • pale or blue lips, fingernails, or skin
  • shortness of breath
  • sleepiness or unusual drowsiness
  • swelling of the face, fingers, feet, or lower legs
  • weight gain

Minor Side Effects

Some of the side effects that can occur with levorphanol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Abnormal dreams
  • absence of or decrease in body movement
  • acid or sour stomach
  • belching
  • change in personality
  • changes in vision
  • delusions
  • dementia
  • discouragement
  • double vision
  • dry mouth
  • feeling sad or empty
  • heartburn
  • hives or welts
  • increase in body movements
  • indigestion
  • irritability
  • itching
  • lack of appetite
  • loss of interest or pleasure
  • loss of memory
  • nausea
  • nervousness
  • problems with memory
  • redness of the skin
  • seeing double
  • skin rash
  • stomach discomfort, upset, or pain
  • sweating
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • upper abdominal or stomach pain
  • vomiting

For Healthcare Professionals

Applies to levorphanol: compounding powder, injectable solution, oral tablet


The adverse effects of levorphanol (the active ingredient contained in Levo-Dromoran) are generally similar to the adverse effects observed with other narcotic analgesics.[Ref]

Nervous system

Opioids may result in psychotic symptoms in some patients.[Ref]

Nervous system side effects include mental and respiratory depression, stupor, delirium, somnolence, and dysphoria.[Ref]


Other side effects including withdrawal symptoms after either abrupt cessation or fast tapering of narcotic analgesics may occur and include agitation, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting and sweating.[Ref]


Cardiovascular adverse effects include hypotension and arrhythmias rarely.[Ref]


Gastrointestinal side effects including nausea, vomiting, and constipation are relatively common effects of narcotic analgesics.[Ref]


Genitourinary side effects including urinary retention has been reported for other narcotic analgesics.[Ref]


Dermatologic side effects including rashes have been reported rarely. Narcotic induced rashes may be related to direct stimulation of histamine release.[Ref]


1. "Multum Information Services, Inc. Expert Review Panel"

2. Covington EC, Gonsalves-Ebrahim L, Currie KO, et al "Severe respiratory depression from patient-controlled analgesia in renal failure." Psychosomatics 30 (1989): 226-8

3. Bellville JW, Forrest WH, Elashoff J, Laska E "Evaluating side effects of analgesics in a cooperative clinical study." Clin Pharmacol Ther 9 (1968): 303-13

4. "Product Information. Levo-Dromoran (levorphanol)." Roche Laboratories, Nutley, NJ.

5. D'Souza M "Unusual reaction to morphine." Lancet 07/11/87 (1987): 98

6. White MJ, Berghausen EJ, Dumont SW, et al "Side effects during continuous epidural infusion of morphine and fentanyl." Can J Anaesth 39 (1992): 576-82

7. Portenoy RK, Foley KM "Chronic use of opioid analgesics in non-malignant pain: report of 38 cases." Pain 25 (1986): 171-86

8. Petersen TK, Husted SE, Rybro L, et al "Urinary retention during I.M. and extradural morphine analgesia." Br J Anaesth 54 (1982): 1175-8

Not all side effects for Levo-Dromoran may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.