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Larotrectinib Side Effects

Medically reviewed by Last updated on Apr 12, 2022.

For the Consumer

Applies to larotrectinib: oral capsule, oral solution

Side effects requiring immediate medical attention

Along with its needed effects, larotrectinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking larotrectinib:

More common

  • Being forgetful
  • black, tarry, stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • chills
  • confusion as to time, place, or person
  • cough
  • discouragement
  • dizziness
  • falls
  • fear, nervousness
  • feeling sad or empty
  • fever
  • headache
  • holding false beliefs that cannot be changed by fact
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • loss of memory
  • lower back or side pain
  • nervousness
  • painful or difficult urination
  • pale skin
  • pounding in the ears
  • problems with memory
  • problems with speech or speaking
  • rapid weight gain
  • seeing, hearing, or feeling things that are not there
  • sleepiness or unusual drowsiness
  • slow or fast heartbeat
  • sore throat
  • tightness in the chest
  • tingling of the hands or feet
  • trouble breathing
  • trouble concentrating
  • trouble sleeping
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • unusual weight gain or loss

Less common

  • Chest pain or discomfort
  • confusion
  • decreased urination
  • diarrhea
  • dry mouth
  • fainting
  • heartburn
  • increase in heart rate
  • increased thirst
  • indigestion
  • irregular heartbeat
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • lightheadedness
  • loss of consciousness
  • muscle pain, cramps, or weakness
  • nausea
  • problems with movement or walking
  • rapid, shallow breathing
  • seizures
  • severe stomach pain, cramping, or burning
  • sunken eyes
  • swelling of the face, ankles, or hands
  • vomiting
  • vomiting of material that looks like coffee grounds, severe and continuing
  • wrinkled skin
  • yellow skin or eyes

Side effects not requiring immediate medical attention

Some side effects of larotrectinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • constipation
  • decreased appetite
  • difficulty in moving
  • increased weight
  • joint pain or swelling
  • muscle stiffness
  • pain in the arms or legs
  • stuffy nose

Less common

  • Lack or loss of strength

For Healthcare Professionals

Applies to larotrectinib: oral capsule, oral solution


Very common (10% or more): Anemia (42%), hypoalbuminemia (35%), neutropenia (23%)[Ref]


Very common (10% or more): Arthralgia (14%), myalgia (14%), muscular weakness (13%), back pain (12%), pain in extremity (12%)[Ref]


Very common (10% or more): Peripheral edema (15%), increased weight (15%), decreased appetite (13%)[Ref]


Common (1% to 10%): Delirium, memory impairment[Ref]


Very common (10% or more): Hepatotoxicity (45%), Increased ALT (45%), increased AST (45%), increased alkaline phosphatase (30%)[Ref]


Very common (10% or more): Cough (26%), dyspnea (18%), nasal congestion (10%)[Ref]


Very common (10% or more): Fatigue (37%), pyrexia (18%), fall (10%)[Ref]


The most common adverse reactions (20% or greater) were fatigue, nausea, dizziness, vomiting, anemia, increased AST, cough, increased ALT, constipation, and diarrhea.[Ref]

Nervous system

Very common (10% or more): Neurotoxicity (53%), dizziness (28%), headache (14%)

Common (1% to 10%): Dysarthria, gait disturbance, tremor, paresthesia

Uncommon (0.1% to 1%): Grade 4 encephalopathy[Ref]


Very common (10% or more): Hypertension (11%)[Ref]


Very common (10% or more): Nausea (29%), vomiting (26%), constipation (23%), diarrhea (22%), abdominal pain (13%)[Ref]

Frequently asked questions


1. "Product Information. Vitrakvi (larotrectinib)." Bayer Pharmaceutical Inc (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.