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Jaypirca Side Effects

Generic name: pirtobrutinib

Medically reviewed by Drugs.com. Last updated on Nov 23, 2023.

Note: This document provides detailed information about Jaypirca.

Applies to pirtobrutinib: oral tablet Side Effects associated with pirtobrutinib. Some dosage forms listed on this page may not apply specifically to the brand name Jaypirca.

Applies to pirtobrutinib: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting this medicine. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 1 week after your last dose. If you think you have become pregnant while using the medicine, tell your doctor right away.

Call your doctor right away if you start to have a cough that would not go away, weight loss, night sweats, fever, chills, flu-like symptoms (eg, runny or stuffy nose, headache, blurred vision, or feeling generally ill), painful or difficult urination, or sores, ulcers, or white spots in the mouth or on the lips. These may be signs that you have an infection.

Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal. These may be signs of bleeding problems.

Pirtobrutinib may lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

This medicine may cause heart rhythm problems (eg, atrial flutter, atrial fibrillation). Check with your doctor right away if you have a fast or irregular heartbeat, trouble breathing, lightheadedness, dizziness, or fainting.

Using this medicine may increase your risk of getting new cancers, including skin cancer. Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before and after having surgery.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Jaypirca

Along with its needed effects, pirtobrutinib (the active ingredient contained in Jaypirca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pirtobrutinib:

More common side effects

  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • body aches or pain
  • chest pain or tightness
  • cough
  • ear congestion
  • fever or chills
  • loss of voice
  • pale skin
  • pinpoint red spots on the skin
  • sneezing
  • sore throat
  • stuffy or runny nose
  • swelling
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common side effects

  • confusion
  • dizziness
  • fainting
  • fast or irregular heartbeat
  • lightheadedness
  • lower back or side pain
  • painful or difficult urination
  • persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • ulcers, sores, or white spots in the mouth
  • white, yellow, or waxy scar-like area

Other side effects of Jaypirca

Some side effects of pirtobrutinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • burning, numbness, tingling, or painful sensations
  • constipation
  • cough
  • diarrhea
  • difficulty in moving
  • joint pain
  • large, flat, blue or purplish patches in the skin
  • muscle or bone pain
  • muscle stiffness
  • nausea
  • pain, swelling, or redness in the joints
  • stomach pain
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For healthcare professionals

Applies to pirtobrutinib: oral tablet.

General adverse events

The most common adverse reactions reported were decreased neutrophils, hemoglobin, platelets, and lymphocytes, as well as fatigue, musculoskeletal pain, bruising, diarrhea, edema, dyspnea, and pneumonia.[Ref]

Dermatologic

Gastrointestinal

Hematologic

Musculoskeletal

Nervous system

Ocular

Oncologic

Other

Respiratory

See also:

References

1. (2023) "Product Information. Jaypirca (pirtobrutinib)." Lilly, Eli and Company

Frequently asked questions

Further information

Jaypirca side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.