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Ixabepilone Side Effects

Medically reviewed by Last updated on Jul 21, 2023.

Applies to ixabepilone: intravenous powder for solution.


Intravenous route (Powder for Solution)

Ixabepilone in combination with capecitabine is contraindicated in patients with AST or ALT greater than 2.5 times the ULN or bilirubin greater than 1 time the ULN due to an increased risk of toxicity and neutropenia-related death.

Serious side effects of Ixabepilone

Along with its needed effects, ixabepilone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ixabepilone:

More common

Less common

Other side effects of Ixabepilone

Some side effects of ixabepilone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to ixabepilone: intravenous powder for injection.


Very common (10% or more): Neutropenia (Grade 4) (36%), leukopenia (41%)

Common (1% to 10%): Febrile neutropenia, infection with neutropenia, anemia, thrombocytopenia

Frequency not reported: Coagulopathy, lymphopenia, hemorrhage[Ref]


Common (1% to 10%): Flushing, rash, dyspnea, bronchospasm, anaphylaxis[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (all Grades) (67%), sensory neuropathy (65%), peripheral neuropathy (Grade 3 or 4) (23%), motor neuropathy (16%), taste disorder (12%)

Common (1% to 10%): Headache, dizziness

Frequency not reported: Cognitive disorder, syncope, cerebral hemorrhage, abnormal coordination, lethargy[Ref]


Common (1% to 10%): Myocardial ischemia, ventricular dysfunction, hot flush

Uncommon (0.1% to 1%): Supraventricular arrhythmia

Frequency not reported: Myocardial infarction, supraventricular arrhythmia, left ventricular dysfunction, angina pectoris, atrial flutter, cardiomyopathy, myocardial ischemia, hypotension, thrombosis, embolism, hypovolemic shock, vasculitis[Ref]


Very common (10% or more): Myalgia/arthralgia (39%), musculoskeletal pain (23%)

Frequency not reported: Muscular weakness, muscle spasms, trismus[Ref]


Very common (10% or more): Nausea (53%), abdominal pain (24%), constipation (22%), stomatitis/mucositis, diarrhea

Common (1% to 10%): Dehydration, gastroesophageal reflux disease

Frequency not reported: Enterocolitis, ileus, colitis, impaired gastric emptying, esophagitis, dysphagia, gastritis, GI hemorrhage[Ref]


Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (64%), alopecia (31%), nail disorder (24%), skin rash (17%), skin hyperpigmentation (14%)

Common (1% to 10%): Pruritus, skin exfoliation

Frequency not reported: Erythema multiforme

Postmarketing reports: Radiation recall[Ref]


Common (1% to 10%): Upper respiratory tract infection, dyspnea, cough

Frequency not reported: Pneumonia, laryngitis, lower respiratory tract infection, pneumonitis, hypoxia, respiratory failure, acute pulmonary edema, dysphonia, pharyngolaryngeal pain[Ref]


Frequency not reported: Acute hepatic failure, jaundice, increased transaminases, increased blood alkaline phosphatase, increased gamma-glutamyltransferase[Ref]


Frequency not reported: Nephrolithiasis, renal failure[Ref]


Very common (10% or more): Anorexia (34%), weight loss (11%)

Frequency not reported: Hyponatremia, metabolic acidosis, hypokalemia, hypovolemia[Ref]


Common (1% to 10%): Increased lacrimation[Ref]


Very common (10% or more): Fatigue/asthenia (60%), pyrexia (10%)

Common (1% to 10%): Edema, pain, chest pain

Frequency not reported: Chills[Ref]


Frequency not reported: Sepsis, infection, neutropenic infection, bacterial infection[Ref]


Common (1% to 10%): Insomnia[Ref]


Frequency not reported: Urinary tract infection[Ref]


1. Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb. 2007.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.