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Generic name: ixabepiloneIX-ab-EP-i-lone ]
Drug class: Mitotic inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 23, 2022.

What is Ixempra?

Ixempra is an injectable cancer medicine.

Ixempra is used to treat advanced breast cancer.

Ixempra is used alone or with another cancer medicine called capecitabine. Ixempra is usually given after other treatments have failed.


You should not use Ixempra along with capecitabine if you have liver problems.

Do not use Ixempra if you are pregnant. It could harm the unborn baby. You should not receive Ixempra if you are allergic to ixabepilone, or to a medication ingredient called Cremophor (synthetic castor oil). You may not be able to receive Ixempra if you have severe liver disease, or severely low platelets or white blood cell counts.

Before you receive Ixempra, tell your doctor if you have liver disease, heart disease, nerve problems, diabetes, bone marrow suppression, or a weak immune system.

Ixabepilone can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, easy bruising, unusual bleeding, burning when you urinate).

Tell your doctor at once if you develop signs of infection, such as fever, chills, body aches, flu symptoms, pale skin, easy bruising or bleeding, or sores in your mouth and throat. Avoid drinking alcohol during your treatment with Ixempra.

Before taking this medicine

You should not be treated with Ixempra if you are allergic to Cremophor (synthetic castor oil).

You may not be able to receive Ixempra if you have:

To make sure Ixempra is safe for you, tell your doctor if you have ever had:

Ixabepilone may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while using Ixempra.

How is Ixempra given?

Ixempra is given as an infusion into a vein. A healthcare provider will give you this injection.

Ixempra is usually given every 3 weeks.

Ixempra must be given slowly, and the infusion can take up to 3 hours to complete.

About 1 hour before you receive Ixempra, you may be given other medications to help prevent certain side effects.

Ixabepilone can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

Dosing information

Usual Adult Dose for Breast Cancer:

40 mg/m2 IV over 3 hours every 3 weeks (the dosage for patients with a BSA exceeding 2.2 m2 should be calculated based on a 2.2 m2 body surface area)

-Premedicate all patients approximately 1 hour prior to administration of this drug to minimize the chance of a hypersensitivity reaction with an H1 antagonist (e.g., diphenhydramine 50 mg orally or equivalent) and an H2 antagonist (e.g., ranitidine 150 to 300 mg orally or equivalent)
-If a patient experiences a hypersensitivity reaction in one cycle, premedicate in subsequent cycles with a corticosteroid (e.g., dexamethasone 20 mg IV 30 minutes prior to infusing this drug or orally 60 minutes prior to infusion) in addition to the H1 and H2 antagonists. Extension of the infusion time should also be considered.

-In combination with capecitabine for the treatment of patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated. Anthracycline resistance is defined as progression while on therapy or within 6 months in the adjuvant setting or 3 months in the metastatic setting). Taxane resistance is defined as progression while on therapy or within 12 months in the adjuvant setting or 4 months in the metastatic setting.
-As monotherapy for the treatment of metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes, and capecitabine.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Ixempra injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Ixempra?

Avoid drinking alcohol.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Grapefruit may interact with ixabepilone and lead to unwanted side effects. Avoid the use of grapefruit products.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Ixempra side effects

Get emergency medical help if you have signs of an allergic reaction to Ixempra: itching, hives, rash; feeling dizzy or faint; warmth or tingly feeling; difficulty breathing, chest tightness; pounding heartbeats or fluttering in your chest; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common Ixempra side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Ixempra?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with ixabepilone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ixempra only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.