Humulin 70 / 30 Side Effects
Generic name: insulin isophane / insulin regular
Medically reviewed by Drugs.com. Last updated on Dec 8, 2021.
Note: This document contains side effect information about insulin isophane / insulin regular. Some of the dosage forms listed on this page may not apply to the brand name Humulin 70 / 30.
For the Consumer
Side effects requiring immediate medical attention
Incidence not known
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred vision
- cold sweats
- cool, pale skin
- decreased urine
- difficulty swallowing
- dry mouth
- fast heartbeat
- hives, itching, or rash
- increased hunger
- increased thirst
- irregular heartbeat
- loss of appetite
- mood changes
- muscle pain or cramps
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- slurred speech
- tightness in the chest
- tingling of the hands or feet
- unusual tiredness or weakness
- unusual weight gain or loss
Side effects not requiring immediate medical attention
Some side effects of insulin isophane/insulin regular may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Weight gain
- redness, swelling, or itching at the injection site
For Healthcare Professionals
Applies to insulin isophane / insulin regular: subcutaneous suspension
Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site
Very rare (less than 0.01%): Systemic reactions[Ref]
Hypersensitivity side effects have included both local and systemic reactions. Local reactions have presented as erythema, swelling, heat, or subcutaneous nodules. They usually occurred within the first two weeks of therapy and then disappear. Systemic allergy is a generalized allergy to insulin which may present as a rash over the whole body, shortness of breath, wheezing, drop in blood pressure, fast pulse, or sweating. Severe cases may be life-threatening.
There have been rare reports of patients with hypersensitivity reactions to human insulins who have tolerated insulins of animal origin.[Ref]
Insulin may cause sodium retention and edema, especially if previously poor metabolic control is improved by intensified insulin therapy.[Ref]
Frequency not reported: Peripheral edema[Ref]
Uncommon (0.1% to 1%): Lipodystrophy
Frequency not reported: Rash, pruritus[Ref]
Very common (10% or more): Hypoglycemia[Ref]
Injection site reactions including pain, redness, hives, inflammation, bruising, swelling, and itching, may occur. These reactions are usually transitory and may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique.[Ref]
Frequency not reported: Injection site reactions[Ref]
Weight gain has been attributed to the anabolic effects of insulin and the decrease in glycosuria.[Ref]
Frequency not reported: Weight gain[Ref]
Frequency not reported: Anti-insulin antibodies[Ref]
Frequency not reported: Acute painful neuropathy[Ref]
Fast improvement in blood glucose has been associated with acute painful neuropathy, which is generally reversible.[Ref]
Frequently asked questions
- Are Humulin and Humalog the same thing?
- Is Novolin the same as Humulin?
- How long can Humulin be unrefrigerated?
- How and where should I inject insulin?
- How long does Humulin last?
More about Humulin 70 / 30 (insulin isophane / insulin regular)
- Drug interactions
- Dosage information
- During pregnancy
- Reviews (1)
- Drug images
- Pricing & coupons
- En español
- Drug class: insulin
Related treatment guides
1. "Product Information. Humulin 70 / 30 (insulin isophane-insulin regular)." Lilly, Eli and Company, Indianapolis, IN.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.