Humulin 70/30 Side Effects

Generic name: insulin isophane / insulin regular

Medically reviewed by Drugs.com. Last updated on May 22, 2024.

Note: This document provides detailed information about Humulin 70/30 Side Effects associated with insulin isophane / insulin regular. Some dosage forms listed on this page may not apply specifically to the brand name Humulin 70/30.

Applies to insulin isophane / insulin regular: subcutaneous suspension.

Serious side effects of Humulin 70/30

Along with its needed effects, insulin isophane/insulin regular may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking insulin isophane/insulin regular:

Other side effects of Humulin 70/30

Some side effects of insulin isophane / insulin regular may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to insulin isophane / insulin regular: subcutaneous suspension.

General adverse events

Adverse reactions observed with insulin therapy include hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, pruritus, weight gain, and edema.^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site
• Very rare (less than 0.01%): Systemic reactions^[Ref]

Hypersensitivity side effects have included both local and systemic reactions. Local reactions have presented as erythema, swelling, heat, or subcutaneous nodules. They usually occurred within the first two weeks of therapy and then disappear. Systemic allergy is a generalized allergy to insulin which may present as a rash over the whole body, shortness of breath, wheezing, drop in blood pressure, fast pulse, or sweating. Severe cases may be life-threatening.

There have been rare reports of patients with hypersensitivity reactions to human insulins who have tolerated insulins of animal origin.^[Ref]

Cardiovascular

• Frequency not reported: Peripheral edema^[Ref]

Insulin may cause sodium retention and edema, especially if previously poor metabolic control is improved by intensified insulin therapy.^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Lipodystrophy
• Frequency not reported: Rash, pruritus^[Ref]

Metabolic

• Very common (10% or more): Hypoglycemia^[Ref]

Ocular

• Frequency not reported: Refraction anomalies, temporary worsening of diabetic retinopathy^[Ref]

Refraction anomalies may occur upon initiation of insulin; symptoms are usually transient. Intensification of insulin therapy may be associated with temporary worsening of diabetic retinopathy.^[Ref]

Local

• Frequency not reported: Injection site reactions^[Ref]

Injection site reactions including pain, redness, hives, inflammation, bruising, swelling, and itching, may occur. These reactions are usually transitory and may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique.^[Ref]

Other

• Frequency not reported: Weight gain^[Ref]

Weight gain has been attributed to the anabolic effects of insulin and the decrease in glycosuria.^[Ref]

Immunologic

• Frequency not reported: Anti-insulin antibodies^[Ref]

Nervous system

• Frequency not reported: Acute painful neuropathy^[Ref]

Fast improvement in blood glucose has been associated with acute painful neuropathy, which is generally reversible.^[Ref]

See also:

Frequently asked questions

• Are Humulin and Humalog the same thing?
• Is Novolin the same as Humulin?
• How long can Humulin be unrefrigerated?
• How long does Humulin last?
• How and where should I inject insulin?

Further information

Humulin 70/30 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer