Guaifenesin / hydromorphone Side Effects
Applies to guaifenesin / hydromorphone: oral syrup
Nervous system side effects of guaifenesin have included dizziness and headache. Central nervous system adverse effects of hydromorphone have included mental depression, dizziness, lightheadedness, respiratory depression (which is sometimes fatal), stupor, delirium, somnolence, agitation, and dysphoria.[Ref]
Opiates may result in psychotic symptoms in some patients.[Ref]
Other side effects of hydromorphone have included withdrawal symptoms, such as agitation, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting and sweating, after either abrupt cessation or fast tapering of narcotic analgesics.[Ref]
Gastrointestinal side effects of guaifenesin have included upset stomach and vomiting with higher than recommended doses. Doses recommended for expectoration are rarely associated with gastrointestinal upset. Gastrointestinal side effects of hydromorphone have included nausea, vomiting, constipation, and dry mouth.[Ref]
Cardiovascular adverse effects have included rare reports of hypotension, shock and arrhythmias.[Ref]
Genitourinary side effects of hydromorphone have included ureteral spasm, spasm of vesicle sphincters, and urinary retention.[Ref]
Dermatologic side effects of guaifenesin have included rash. Narcotic-induced rash has also been reported.[Ref]
1. Bellville JW, Forrest WH, Elashoff J, Laska E "Evaluating side effects of analgesics in a cooperative clinical study." Clin Pharmacol Ther 9 (1968): 303-13
2. Covington EC, Gonsalves-Ebrahim L, Currie KO, et al "Severe respiratory depression from patient-controlled analgesia in renal failure." Psychosomatics 30 (1989): 226-8
3. "Product Information. Dilaudid Cough Syrup (guaifenesin-hydromorphone)" Knoll Pharmaceutical Company, Mount Olive, NJ.
4. D'Souza M "Unusual reaction to morphine." Lancet 07/11/87 (1987): 98
5. Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):
6. "Product Information. Robitussin (guaifenesin)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
7. White MJ, Berghausen EJ, Dumont SW, et al "Side effects during continuous epidural infusion of morphine and fentanyl." Can J Anaesth 39 (1992): 576-82
8. Miser AW, Chayt KJ, Sandlund JT, Cohen PS, Dothage JA, Miser JS "Narcotic withdrawal syndrome in young adults after the therapeutic use of opiates." Am J Dis Child 140 (1986): 603-4
9. Portenoy RK, Foley KM "Chronic use of opioid analgesics in non-malignant pain: report of 38 cases." Pain 25 (1986): 171-86
10. Cohen J, Tattersfield H, Lloyd D, Cantopher T "A request for a strong analgesic." Practitioner 234 (1990): 691-4
11. Petersen TK, Husted SE, Rybro L, et al "Urinary retention during I.M. and extradural morphine analgesia." Br J Anaesth 54 (1982): 1175-8
12. de Cuyper C, Goeteyn M "Systemic contact dermatitis from subcutaneous hydromorphone." Contact Dermatitis 27 (1992): 220-3
Not all side effects for guaifenesin / hydromorphone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about guaifenesin/hydromorphone
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.