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Gleevec Side Effects

Generic name: imatinib

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 17, 2025.

Note: This document provides detailed information about Gleevec.

Applies to imatinib: oral tablet Side Effects associated with imatinib. Some dosage forms listed on this page may not apply specifically to the brand name Gleevec.

Applies to imatinib: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects. Be sure to keep all appointments.

Using this medicine while you are pregnant can harm your unborn baby. Use a highly effective form of birth control (especially if you are a sexually active female patient) during treatment and for 14 days after your last dose to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.

Some serious side effects such as black, tarry stools, severe stomach pain, or vomiting of blood or material that looks like coffee grounds can occur during treatment with this medicine.

While you are being treated with imatinib (the active ingredient contained in Gleevec) and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Imatinib may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have recently taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Imatinib can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

If you are rapidly gaining weight, having chest pain or discomfort, extreme tiredness or weakness, difficulty with breathing, uneven heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of heart problems or your body keeping too much water.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause slow growth. If your child is using this medicine, the doctor will need to keep track of your child's height and weight to make sure that your child is growing properly.

This medicine may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, a rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness.

This medicine may cause dizziness, drowsiness, or trouble in seeing clearly. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert or able to see well.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Serious side effects of Gleevec

Along with its needed effects, imatinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking imatinib:

More common side effects

  • abdominal or stomach pain, cramping, burning, or tenderness
  • bleeding from wound after surgery
  • bleeding gums
  • bleeding problems
  • bloating or swelling of the face, hands, lower legs, or feet
  • blood in the urine
  • bloody eye
  • bloody nose
  • blue lips and fingernails
  • blurred vision
  • body aches or pain
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • cough
  • coughing that sometimes produces a pink frothy sputum
  • coughing up blood
  • decrease in the amount of urine
  • decreased appetite
  • decreased urination
  • diarrhea
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • ear congestion
  • fever
  • general feeling of discomfort or illness
  • headache
  • inability to speak
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • irregular heartbeat
  • itching or skin rash
  • joint pain
  • large, flat, blue, or purplish patches on the skin
  • loss of appetite
  • loss of voice
  • mood changes
  • muscle aches and pain
  • muscle cramps
  • nausea and vomiting
  • noisy, rattling breathing
  • nosebleed
  • numbness or tingling in the hands, feet, or lips
  • pain or tenderness around the eyes and cheekbones
  • painful or difficult urination
  • pale skin
  • prolonged bleeding from cuts
  • rapid weight gain
  • red, black, bloody, or tarry stools
  • red or dark brown urine
  • redness of the eye
  • seizures
  • shivering
  • slurred speech
  • small red or purple spots on the skin
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stuffy or runny nose
  • sweating
  • swelling in the legs and ankles
  • swollen glands
  • temporary blindness
  • tightness in the chest
  • trouble sleeping
  • troubled breathing at rest
  • troubled breathing when moving or walking
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weakness in the arm or leg on one side of the body, sudden and severe
  • yellow eyes or skin

Incidence not known

  • anxiety
  • blistering, peeling, or loosening of the skin
  • change in vision not present before treatment
  • chest pain, possibly moving to the left arm, neck, or shoulder
  • confusion
  • delayed or slow growth in children
  • irregular, fast or slow, or shallow breathing
  • nausea, heartburn, or indigestion, severe and continuing
  • pain in the bones
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • seeing floaters, veil, or curtain appearing across part of vision
  • severe abdominal or stomach pain, cramping, or burning
  • severe constipation
  • severe vomiting
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area

Other side effects of Gleevec

Some side effects of imatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • acid or sour stomach
  • belching
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • discouragement
  • excess air or gas in the stomach or intestines
  • fear or nervousness
  • feeling sad or empty
  • feeling unusually cold
  • full or bloated feeling
  • increased bowel movements
  • irritability
  • lack or loss of strength
  • loose stools
  • loss of interest or pleasure
  • muscle stiffness
  • night sweats
  • passing gas
  • stomach discomfort, upset, or pain
  • swollen joints
  • trouble concentrating
  • weight loss

Less common side effects

  • back pain
  • bad, unusual, or unpleasant (after) taste
  • change in taste
  • watering of the eyes

For healthcare professionals

Applies to imatinib: oral capsule, oral solution, oral tablet.

Cardiovascular adverse events

Dermatologic

Gastrointestinal

Genitourinary

Hematologic

Hepatic

Hypersensitivity

Immunologic

Metabolic

Musculoskeletal

Nervous system

Ocular

Oncologic

Other

Psychiatric

Renal

Respiratory

See also:

References

1. (2022) "Product Information. Gleevec (imatinib)." Novartis Pharmaceuticals

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Frequently asked questions

Further information

Gleevec side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.