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Gabitril Side Effects

Generic Name: tiagabine

Note: This page contains information about the side effects of tiagabine. Some of the dosage forms included on this document may not apply to the brand name Gabitril.

For the Consumer

Applies to tiagabine: oral capsule, oral tablet

In addition to its needed effects, some unwanted effects may be caused by tiagabine (the active ingredient contained in Gabitril). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking tiagabine, check with your doctor or nurse as soon as possible:

More common:
  • Blue or purple spots on skin
  • difficulty in concentrating or paying attention
Less common:
  • Burning, numbness, or tingling sensations
  • clumsiness or unsteadiness
  • confusion
  • itching
  • mental depression
  • speech or language problems
Rare
  • Agitation
  • bloody or cloudy urine
  • burning, pain, or difficulty in urinating
  • frequent urge to urinate
  • generalized weakness
  • hostility
  • memory problems
  • quick to react or overreact emotionally
  • rash
  • uncontrolled back-and-forth and/or rolling eye movements
  • walking in unusual manner
Symptoms of overdose:
  • Agitation (severe)
  • clumsiness or unsteadiness (severe)
  • coma
  • confusion (severe)
  • drowsiness (severe)
  • increase in seizures
  • mental depression
  • severe muscle twitching or jerking
  • sluggishness
  • speech problems (severe)
  • weakness

Minor Side Effects

Some of the side effects that can occur with tiagabine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Chills
  • diarrhea
  • dizziness
  • drowsiness
  • fever
  • headache
  • muscle aches or pain
  • nervousness
  • sore throat
  • tremor
  • unusual tiredness or weakness
  • vomiting
Less common:
  • Abdominal pain
  • flushing
  • impaired vision
  • increased appetite
  • increased cough
  • mouth ulcers
  • muscle weakness
  • nausea
  • pain
  • trouble in sleeping

For Healthcare Professionals

Applies to tiagabine: oral tablet

Dermatologic

Very common (10% or more): Common (1% to 10%): Rash, pruritus
Uncommon (0.1% to 1%): Dermatitis bullous dermatitis, bruising
Frequency not reported: Vesiculobullous rash, exfoliative dermatitis[Ref]

Cardiovascular

Common (1% to 10%): Vasodilation[Ref]

Gastrointestinal

Very common (10% or more): Nausea (11%)
Common (1% to 10%): Abdominal pain, diarrhea, vomiting, increased appetite, mouth ulceration[Ref]

Hepatic

Very rare (less than 0.01%): Abnormal hepatic function (elevated SGPT, GGT)[Ref]

Musculoskeletal

Common (1% to 10%): Myasthenia, muscle twitching[Ref]

Immunologic

Very common (10% or more): Infection (15%)
Common (1% to 10%): Influenza syndrome[Ref]

Nervous system

Very common (10% or more): Dizziness (27%), asthenia (20%), somnolence (18%), nervousness (10%), tremor
Common (1% to 10%): Ataxia, paresthesia, abnormal gait, nystagmus, speech disorder
Uncommon (0.1% to 1%): Nonconvulsive status epilepticus
Frequency not reported: Encephalopathy[Ref]

Ocular

Very common (10% or more): Blurred vision, visual field defects
Common (1% to 10%): Amblyopia, diplopia[Ref]

Respiratory

Common (1% to 10%): Pharyngitis, cough, rhinitis[Ref]

Psychiatric

Common (1% to 10%): Difficulty with concentration/attention, insomnia, confusion, memory loss, depressed mood, emotional liability, hostility/aggression, agitation
Uncommon (0.1% to 1%): Depression, psychosis
Rare (0.01% to 0.1%): Hallucinations, delusion[Ref]

Other

Very common (10% or more): Accidental injury (17%)
Common (1% to 10%): Pain (unspecified), fatigue[Ref]

References

1. "Product Information. Tiagabine Hydrochloride (tiaGABine (tiagabine))." Teva Pharmaceuticals USA, North Wales, PA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Gabitril may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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