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Fidaxomicin Side Effects

Medically reviewed by Last updated on Apr 1, 2023.

Applies to fidaxomicin: oral powder for suspension, oral tablet.

Serious side effects of Fidaxomicin

Along with its needed effects, fidaxomicin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fidaxomicin:

Less common

Incidence not known

Other side effects of Fidaxomicin

Some side effects of fidaxomicin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to fidaxomicin: oral granule for reconstitution, oral tablet.


Very common (10% or more): Nausea (up to 11%)

Common (1% to 10%): Vomiting, abdominal pain, diarrhea, constipation, gastrointestinal hemorrhage, upper abdominal pain

Uncommon (0.1% to 1%): Abdominal distension, flatulence, dry mouth

Frequency not reported: Abdominal tenderness, dyspepsia, dysphagia, intestinal obstruction, megacolon, lower abdominal pain[Ref]


Common (1% to 10%): Hypokalemia, hyperkalemia, hypomagnesemia

Uncommon (0.1% to 1%): Anorexia, decreased appetite

Frequency not reported: Hyperglycemia, metabolic acidosis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Dysgeusia[Ref]


Common (1% to 10%): Pyrexia, peripheral edema, fatigue

Uncommon (0.1% to 1%): Chills

Frequency not reported: Increased blood alkaline phosphatase, decreased blood bicarbonate[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Anemia, neutropenia

Frequency not reported: Decreased platelet count[Ref]


Postmarketing reports: Hypersensitivity reactions (dyspnea, angioedema, rash, pruritus)[Ref]


Common (1% to 10%): Dyspnea, pneumonia[Ref]


Common (1% to 10%): Insomnia[Ref]


Common (1% to 10%): Hypotension[Ref]


Common (1% to 10%): Pruritus

Uncommon (0.1% to 1%): Rash

Frequency not reported: Drug eruption, urticaria, follicular rash, maculopapular rash, exfoliative rash[Ref]


Common (1% to 10%): Back pain[Ref]


Uncommon (0.1% to 1%): Increased ALT

Frequency not reported: Increased hepatic enzymes, increased AST[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals. 2011.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.