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Fematrol Side Effects

Generic Name: bisacodyl

Note: This document contains side effect information about bisacodyl. Some of the dosage forms listed on this page may not apply to the brand name Fematrol.

For the Consumer

Applies to bisacodyl: oral tablets delayed-release, rectal suppositories, rectal suspension

Side effects include:

Some degree of abdominal discomfort, nausea, cramps, griping, and/or faintness with therapeutic doses.

Diarrhea, GI irritation, and fluid and electrolyte depletion.

Gastric irritation and the possibility of vomiting if enteric coating of tablets is disrupted. (See Advice to Patients.)

Rectal administration of bisacodyl (the active ingredient contained in Fematrol) suspensions or suppositories may cause irritation and a sensation of burning of the rectal mucosa and mild proctitis.

Hepatotoxicity if sufficient tannic acid is absorbed from bisacodyl tannex.

For Healthcare Professionals

Applies to bisacodyl: compounding powder, oral delayed release tablet, rectal enema, rectal suppository


Bisacodyl causes acute nonspecific inflammatory injury to the rectal mucosa, which can confound the assessment of patients with suspected inflammatory bowel disease.

The surreptitious abuse of laxatives is a common cause of severe chronic diarrhea. In some cases, the stool contains fecal leukocytes, which, in this case, is indicative of the irritant effect of bisacodyl (the active ingredient contained in Fematrol) (nonspecific colonic mucosal inflammation), and not necessarily of infection. Surreptitious abuse of laxatives due to bisacodyl can be determined by urinalysis for a metabolite, bisacodyl diphenol. In some cases, stool analysis for bisacodyl could be considered in the diagnostic assessment.

Abdominal cramping has been described as a mild, colicky discomfort. This can be a problem since cramping my indicate not only a side effect of bisacodyl, but underlying gastrointestinal pathology.

Abdominal distension and vomiting are less common gastrointestinal side effects.[Ref]

Gastrointestinal side effects have been reported the most frequently. These have included abdominal cramping, diarrhea, abdominal distention, and vomiting. Severe diarrhea has been reported as a possible result of surreptitious laxative abuse. The sensation of rectal "burning" with administration of bisacodyl enema has been reported.[Ref]


The metabolic consequences of some Fleet bisacodyl (the active ingredient contained in Fematrol) enema preparation kits that contain monobasic or dibasic sodium phosphate in patients with renal insufficiency can be profound. Due to the sodium and phosphate absorption, severe hypernatremia, hypophosphatemia, and hypocalcemia may occur.[Ref]

Metabolic side effects have included severe hypernatremia, hypophosphatemia, and hypocalcemia. These effects have been reported primarily with Fleet bisacodyl enema preparation kits that contain monobasic or dibasic sodium phosphate and administered to patients with renal insufficiency. Fleet bisacodyl enemas without these ingredients may be used safely in such patients.[Ref]


1. Waldman S "Letter: Drug-associated colitis." J Pediatr 88 (1976): 704-5

2. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc, Woodbridge, NJ.

3. Meisel JL, Bergman D, Graney D, Saunders DR, Rubin CE "Human rectal mucosa: proctoscopic and morphological changes caused by laxatives." Gastroenterology 72 (1977): 1274-9

4. Christie D "Drug-associated colitis (reply)." J Pediatr 88 (1976): 705

5. Fonkalsrud EW, Keen J "Hypernatremic dehydration from hypertonic enemas in congenital megacolon." JAMA 199 (1967): 584-6

6. Kacere RD, Srivatsa SS, Tremaine WJ, Ebnet LE, Batts KP "Chronic diarrhea due to surreptitious use of bisacodyl: case reports and methods for detection." Mayo Clin Proc 68 (1993): 355-7

7. Saunders DR, Haggitt RC, Kimmey MB, Silverstein FE "Morphological consequences of bisacodyl on normal human rectal mucosa: effect of a prostaglandin E1 analog on mucosal injury." Gastrointest Endosc 36 (1990): 101-4

8. McConnell TH "Fatal hypocalcemia from phosphate absorption from laxative preparation." JAMA 216 (1971): 147-8

9. Clarkston WK, Smith OJ "The use of GoLYTELY and Dulcolax in combination in outpatient colonoscopy." J Clin Gastroenterol 17 (1993): 146-8

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Fematrol (bisacodyl)

Consumer resources

Other brands: Dulcolax, Correctol, Bisa-Lax, Fleet Bisacodyl

Professional resources

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