Bisacodyl use while Breastfeeding
Drugs containing Bisacodyl: Dulcolax, Bisac-Evac, Dulcolax Laxative, Correctol, Laxative Gentle Suppositories, Bisco-Lax, Colax, Doxidan Tablet, Ducodyl, Fleet Bisacodyl, Show all 36 »
Bisacodyl Levels and Effects while Breastfeeding
Summary of Use during Lactation
Bisacodyl is not absorbed from the gastrointestinal tract, and its active metabolite, which is absorbed, is not detectable in breastmilk. Bisacodyl can be taken during breastfeeding and no special precautions are required.
Drug Levels
Maternal Levels. Sixteen postpartum women who were not breastfeeding, but were producing at least 200 mL of milk daily by breast pump were given either oral enteric-coated bisacodyl tablets (Dulcolax) 10 mg daily or oral liquid sodium picosulfate (Laxoberal) 10 mg daily for 7 days. Both drugs are prodrugs metabolized to the active drug, bis-(p-hydroxyphenyl)-2-pyridyl-2-methane (BHPM). All breastmilk was collected daily from the day before drug administration to 2 days after the last dose. Free and conjugated BHPM were undetectable (<1 mcg/L) in all milk samples.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Docusate, Magnesium Hydroxide, Psyllium, Senna
References
1. Friedrich C, Richter E, Trommeshauser D et al. Lack of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel group, multiple dose study in healthy lactating women. Drug Metab Pharmacokinet. 2011;26:458-64. PMID: 21697613
Bisacodyl Identification
Substance Name
Bisacodyl
CAS Registry Number
603-50-9
Drug Class
Cathartics
Gastrointestinal Agents
Administrative Information
LactMed Record Number
448
Last Revision Date
20130907
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