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Magnesium Hydroxide use while Breastfeeding

Drugs containing Magnesium Hydroxide: Mylanta, Maalox, Phillips' Milk of Magnesia, Pepcid Complete, Milk of Magnesia, Mylanta Maximum Strength, Maalox Advanced Regular Strength, Mylanta Ultimate Strength, Dulcolax Milk of Magnesia, Rolaids Extra Strength, Show all 85 »Rolaids Advanced, Almacone, Mag-al Plus, Flanax Antacid Liquid, Maalox Advanced Maximum Strength, Mylanta Tonight, Rolaids Regular Strength, Ex-Lax Milk of Magnesia, Rolaids Ultra Strength, Dual-Action Acid Controller Complete, Complete Acid Reducer plus Antacid, Dual Action Complete, Acid Controller Complete Dual Action, Mylanta Maximum Strength Cherry, Duo Fusion, Tums Dual Action, Acid Reducer Plus Antacid, Acid Controller Complete, Mintox Maximum Strength, Magnaprin, Rolaids Ultra Strength Softchews, Fast Acting Mylanta, Mylanta Gelcap, Mi-Acid Double Strength, Mylanta Ultra, Masanti Supreme, Mylanta Supreme, Tempo, Rolaids Multi-Symptom, Advanced Formula Di-Gel, Di-Gel Mint, Di-Gel Lemon, Pedia-Lax Chewable Tablets, Phillips' Haleys M-O, Haley's M-O, Mintox Extra Strength, Urban, Mintox, Mintox Tablets, Mylanta Fast Acting, Milantex Maximum Strength, Milantex, Rulox, Maldroxal, Alamag, Maalox HRF, Masanti DS, Rulox 1, ConRx AR, Maalox TC, FIRST Mouthwash BLM, Aspir-Mox IB, Aspir-Mox, Arthritis Pain Formula, Mylanta DS Fast Acting, Mi-Acid, Aldroxicon II, Rulox Plus, Aldroxicon I, Maldroxal Plus, Urban DS, Aspirin Buffered, Uni-Lan II, Uni-Lan, Di-Gel, Magaant, Masanti, Gelusil, Mylagen-II, Mylagen, Mintox Plus, Almacone-2, Mi-Acid II, Alamag Plus, Zegerid with Magnesium Hydroxide

Medically reviewed by Drugs.com. Last updated on Nov 21, 2019.

Magnesium Hydroxide Levels and Effects while Breastfeeding

Summary of Use during Lactation

A study on the use of magnesium hydroxide during breastfeeding found no adverse reactions in breastfed infants. Intravenous magnesium increases milk magnesium concentrations only slightly. Oral absorption of magnesium by the infant is poor, so maternal magnesium hydroxide is not expected to affect the breastfed infant's serum magnesium. Magnesium hydroxide supplementation during pregnancy might delay the onset of lactation, but it can be taken during breastfeeding and no special precautions are required.

Drug Levels

Maternal Levels. Ten women with pre-eclampsia were given 4 grams of magnesium sulfate intravenously followed by 1 gram per hour until 24 hours after delivery. While the average serum magnesium was 35.5 mg/L in treated women compared to 18.2 mg/L in 5 untreated controls, colostrum magnesium levels at the time of discontinuation of the infusion was 64 mg/L in treated women and 48 mg/L in the controls. By 48 hours after discontinuation, colostrum magnesium levels were only slightly above control values and by 72 hours they were virtually identical to controls.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Fifty mothers who were in the first day postpartum received 15 mL of either mineral oil or an emulsion of mineral oil and magnesium hydroxide equivalent to 900 mg of magnesium hydroxide, although the exact number who received each product was not stated. Additional doses were given on subsequent days if needed. None of the breastfed infants were noted to have any markedly abnormal stools, but all of the infants also received supplemental feedings.[2]

Effects on Lactation and Breastmilk

One mother who received intravenous magnesium sulfate for 3 days for pregnancy-induced hypertension had lactogenesis II delayed until day 10 postpartum. No other specific cause was found for the delay, although a complete work-up was not done.[3] A subsequent controlled clinical trial found no evidence of delayed lactation in mothers who received intravenous magnesium sulfate therapy.[4] Some, but not all, studies have found a trend toward increased time to the first feeding or decreased sucking in infants of mothers treated with intravenous magnesium sulfate during labor because of placental transfer of magnesium to the fetus.[4][5]

A study in 40 pairs of matched healthy women with vaginally delivered singleton pregnancies, outcome endpoints were compared in those receiving continuous oral magnesium aspartate HCl supplementation mean dose of 459 mg daily (range 365 to 729 mg of magnesium daily) for at least 4 weeks before delivery versus non-supplemented controls. In the magnesium group, significantly fewer women could breastfeed their infants exclusively at discharge (63% vs 80%).[6]

References

1.
Cruikshank DP, Varner MW, Pitkin RM. Breast milk magnesium and calcium concentrations following magnesium sulfate treatment. Am J Obstet Gynecol. 1982;143:685-8. [PubMed: 7091241]
2.
Baldwin WF. Clinical study of senna administration to nursing mothers. Can Med Assoc J. 1963;89:566-7. [PMC free article: PMC1921820] [PubMed: 14045350]
3.
Haldeman W. Can magnesium sulfate therapy impact lactogenesis? J Hum Lact. 1993;9:249-52. [PubMed: 8260059]
4.
Riaz M, Porat R, Brodsky NL et al. The effects of maternal magnesium sulfate treatment on newborns: a prospective controlled study. J Perinatol. 1998;18:449-54. [PubMed: 9848759]
5.
Rasch DK, Huber PA, Richardson CJ et al. Neurobehavioral effects of neonatal hypermagnesemia. J Pediatr. 1982;100:272-6. [PubMed: 7199083]
6.
Meier B, Huch R, Zimmermann R et al. Does continuing oral magnesium supplementation until delivery affect labor and puerperium outcome? Eur J Obstet Gynecol Reprod Biol. 2005;123:157-61. [PubMed: 15899543]

Substance Identification

Substance Name

Magnesium Hydroxide

CAS Registry Number

1309-42-8

Drug Class

  • Breast Feeding
  • Lactation
  • Antacids
  • Cathartics
  • Gastrointestinal Agents
  • Magnesium Compounds

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