Estreva Side Effects

Generic name: estradiol

Medically reviewed by Drugs.com. Last updated on Jan 3, 2024.

Note: This document contains side effect information about estradiol. Some dosage forms listed on this page may not apply to the brand name Estreva.

For healthcare professionals

Applies to estradiol: compounding powder, intramuscular solution, oral tablet, transdermal emulsion, transdermal film extended release, transdermal gel, transdermal spray, vaginal ring.

General adverse events

The most common adverse reactions associated with use of estradiol (the active ingredient contained in Estreva) (oral, transdermal spray/gel/film/patches, vaginal ring, IM injection) include breast pain, abdominal pain, back pain, arthralgia, headache, infection, nasopharyngitis, sinusitis, sinus headache, and upper respiratory tract infection.^[Ref]

Cardiovascular

• Common (1% to 10%): Varicose veins, cardiac symptoms (e.g. palpitations), hot flush
• Uncommon (0.1% to 1%): Hypertension, venous thromboembolic disease, superficial phlebitis, vascular purpura
• Rare (less than 0.1%): Arterial hypertension
• Frequency not reported: Myocardial infarction, thrombophlebitis
• Postmarketing reports: Deep vein thrombosis, changes in blood pressure, chest pain, increased blood pressure, irregular heart rate, myocardial infarction, pulmonary embolism, cerebrovascular accident (stroke), hemiparesis, transient ischemic attack, thrombosis, palpitations, unstable angina

Dermatologic

• Common (1% to 10%): Pruritus
• Uncommon (0.1% to 1%): Rash, acne, alopecia, dry skin, nail disorder, skin nodule, hirsutism, erythema nodosum, urticaria acne, dry skin, nail disorder, alopecia, skin nodule
• Rare (less than 0.1%): Skin discoloration
• Frequency not reported: Chloasma or melasma
• Postmarketing reports: Urticaria, erythematous or pruritic rash, alopecia, hyperhidrosis, night sweats, contact dermatitis, eczema, erythema multiforme, erythema nodosum, hirsutism

Gastrointestinal

• Very common (10% or more): Abdominal pain (up to 16%)
• Common (1% to 10%): Flatulence, nausea, diarrhea, abdominal distension, constipation, dyspepsia
• Uncommon (0.1% to 1%): Vomiting, rectal disorder
• Frequency not reported: Gastroesophageal reflux disease
• Postmarketing reports: Pancreatitis, vomiting, hemorrhage, diarrhea, swollen tongue, lip swelling, oral paresthesia

Genitourinary

• Common (1% to 10%): Vulvovaginal pruritus, vulvovaginal mycotic infection, moniliasis genital, leukorrhea, vaginal hemorrhage, vaginal discharge, vaginal discomfort, menopause symptoms, breakthrough bleeding or spotting, dysmenorrhea, breast swelling, menorrhagia, metrorrhagia, endometrial hyperplasia
• Uncommon (0.1% to 1%): Urinary problems, vaginitis/vaginal candidosis
• Postmarketing reports: Vaginal irritation, vaginal pain, genital pruritus, changes in bleeding pattern, pelvic pain, vaginal ulceration or erosion, uterine fibroids

Hematologic

• Postmarketing reports: Hemolytic anemia

Hepatic

• Uncommon (0.1% to 1%): Gamma-glutamyl transferase increased
• Rare (less than 0.1%): Liver function tests abnormalities
• Frequency not reported: Enlargement of hepatic hemangiomas, increased incidence of gallbladder disease
• Postmarketing reports: Cholestatic jaundice, cholecystitis, cholelithiasis, portal vein thrombosis

Hypersensitivity

• Rare (less than 0.1%): Anaphylactic reaction (with a past history of allergic reaction)
• Postmarketing reports: Anaphylactic reactions, hypersensitivity

Local

• Common (1% to 10%): Skin irritation (topical gel)
• Postmarketing reports: Application site reaction

Metabolic

• Uncommon (0.1% to 1%): Hypercholesterolemia
• Rare (less than 0.1%): Glucose intolerance
• Frequency not reported: Porphyria, hypocalcemia, increased triglycerides
• Postmarketing reports: Fluid retention

Musculoskeletal

• Very common (10% or more): Back pain (11%), arthralgia (11%)
• Common (1% to 10%): Leg cramps, neck pain, limb pain
• Postmarketing reports: Muscle spasms

Nervous system

• Very common (10% or more): Headache (up to 50%)
• Common (1% to 10%): Migraine, dizziness
• Uncommon (0.1% to 1%): Vertigo
• Rare (less than 0.1%): Aggravation of epilepsy
• Frequency not reported: Chorea, dementia
• Postmarketing reports: Migraine aggravated, paresthesia, dizziness

Ocular

• Uncommon (0.1% to 1%): Vision abnormal
• Frequency not reported: Retinal vascular thrombosis, steepening of corneal curvature
• Postmarketing reports: Visual disturbances, contact lens intolerance, blindness

Oncologic

• Uncommon (0.1% to 1%): Benign breast neoplasm, benign endometrial neoplasm
• Postmarketing reports: Endometrial cancer, breast cancer

Other

• Very common (10% or more): Breast tenderness/pain (up to 29%), infection (up to 12%), pain (up to 11%)
• Common (1% to 10%): Edema, influenza, influenza-like illness, asthenia
• Uncommon (0.1% to 1%): Weight increased, fever, asthenia, abnormal laboratory test, peripheral edema
• Rare (less than 0.1%): Galactorrhea
• Postmarketing reports: Drug ineffectiveness, blood estrogen increase, fatigue, exacerbation of hereditary angioedema, toxic shock syndrome (vaginal rings), fibrocystic breast disease, breast disorder, breast mass, breast enlargement, breast pain, nipple pain, breast discharge, medical device complication, peripheral edema, reduced carbohydrate tolerance

Psychiatric

• Common (1% to 10%): Depression, insomnia, lethargy
• Uncommon (0.1% to 1%): Sleep disorders, nervousness, mood swings, impaired concentration, euphoria, agitation, anxiety
• Rare (less than 0.1%): Change in libido
• Frequency not reported: Affect lability
• Postmarketing reports: Vaginismus, insomnia, anxiety, irritability, mood disturbances

Renal

• Uncommon (0.1% to 1%): Increased urinary frequency/urgency, urinary incontinence, cystitis, urine discoloration, hematuria

Respiratory

• Very common (10% or more): Nasopharyngitis (up to 19.6%), upper respiratory tract infection (up to 17%), sinusitis (up to 13.1%), sinus headache (up to 10.6%)
• Common (1% to 10%): Pharyngitis, rhinitis, sinus congestion
• Frequency not reported: Exacerbation of asthma
• Postmarketing reports: Dyspnea, pharyngeal edema

See also:

Further information

Estreva side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer