Entresto Sprinkle Side Effects

Generic name: sacubitril / valsartan

Medically reviewed by Drugs.com. Last updated on Jul 13, 2024.

Note: This document provides detailed information about Entresto Sprinkle Side Effects associated with sacubitril / valsartan. Some dosage forms listed on this page may not apply specifically to the brand name Entresto Sprinkle.

Applies to sacubitril / valsartan: oral tablet.

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

Do not take this medicine for at least 36 hours before or after you take an ACE inhibitor medicine.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position or if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.

Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Entresto Sprinkle

Along with its needed effects, sacubitril/valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sacubitril / valsartan:

Other side effects of Entresto Sprinkle

Some side effects of sacubitril / valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to sacubitril / valsartan: oral pellet, oral tablet.

General adverse events

The most common adverse reactions were hypotension, hyperkalemia, cough, dizziness, and renal failure.^[Ref]

Cardiovascular

• Very common (10% or more): Hypotension (18%)
• Common (1% to 10%): Orthostasis^[Ref]

Metabolic

• Very common (10% or more): Potassium greater than 5.5 mEq/L (16%), hyperkalemia (12%)^[Ref]

Renal

• Very common (10% or more): Serum creatinine increased greater than 50% (16%)
• Common (1% to 10%): Renal failure/acute renal failure^[Ref]

Respiratory

• Common (1% to 10%): Cough^[Ref]

Nervous system

• Common (1% to 10%): Dizziness^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Angioedema
• Postmarketing reports: Rash, pruritus^[Ref]

The incidence of angioedema was 2.4% in Black patients.^[Ref]

Hematologic

• Common (1% to 10%): Hemoglobin/hematocrit decreased greater than 20%^[Ref]

Other

• Common (1% to 10%): Falls^[Ref]

Immunologic

• Postmarketing reports: Hypersensitivity, anaphylactic reaction

See also:

Frequently asked questions

• Does Entresto improve ejection fraction?
• How much does Entresto cost per month?
• Is Entresto a blood thinner and does it lower blood pressure?

Further information

Entresto Sprinkle side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer