Enalaprilat Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 30, 2024.

Applies to enalaprilat: intravenous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects .

Stop using this medicine and call your doctor right away if you have swelling of the face, arms, legs, eyes, lips, or tongue, or problems with swallowing or breathing. These are symptoms of a condition called angioedema .

You may experience lightheadedness during the first few days with this medicine. If this becomes severe and you faint, talk to your doctor right away .

Tell your doctor immediately if you have any signs of infection such as chills, sore throat, or fever. These may be symptoms of an immune system condition called neutropenia .

Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away .

Check with your doctor right away if you have symptoms of jaundice (yellow skin or eyes) because these may be signs of a serious liver condition .

This medicine may increase the amount of potassium in your blood. Do not use salt substitutes containing potassium without first checking with your doctor .

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests .

Serious side effects of enalaprilat

Along with its needed effects, enalaprilat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking enalaprilat:

Other side effects of enalaprilat

Some side effects of enalaprilat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to enalaprilat: compounding powder, intravenous solution, oral liquid, oral tablet.

General adverse events

The most frequently reported side effects included congestive heart failure, coronary artery disease, cough, dizziness, postural dizziness, fatigue, headache, hypotension, hypertension, hyperkalemia, microalbuminuria, and vomiting.^[Ref]

Cardiovascular

• Common (1% to 10%): Angina pectoris, chest pain, edema, hypotension, myocardial infarction, orthostatic hypotension, rhythm disturbances, tachycardia
• Uncommon (0.1% to 1%): Flushing, palpitation, Raynaud's phenomenon
• Frequency not reported: Atrial tachycardia, atrial bradycardia, atrial fibrillation, cardiac arrest, vasculitis

Dermatologic

• Uncommon (0.1% to 1%): Alopecia, angioedema, diaphoresis, erythema multiforme, hyperhidrosis, pemphigus, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
• Rare (0.01% to 0.1%): Erythroderma, exfoliative dermatitis
• Frequency not reported: Dermatologic manifestations, erythema with vasculitis, photosensitivity, severe skin reactions

Endocrine

• Uncommon (0.1% to 1%): Syndrome of inappropriate ADH secretion
• Frequency not reported: Gynecomastia

Gastrointestinal

• Very common (10% or more): Nausea
• Common (1% to 10%): Abdominal pain, diarrhea, vomiting
• Uncommon (0.1% to 1%): Constipation, dry mouth, dysgeusia, dyspepsia, gastric irritation, ileus, pancreatitis, peptic ulcer, stomatitis
• Rare (0.01% to 0.1%): Aphthous ulceration, glossitis
• Very rare (less than 0.01%): Intestinal angioedema
• Frequency not reported: Melena

Genitourinary

• Frequency not reported: Impotence

Hematologic

• Uncommon (0.1% to 1%): Anemia, aplastic anemia, eosinophilia, hemolytic anemia, leukocytosis
• Rare (less than 0.1%): Agranulocytosis, bone marrow depression, decreased hemoglobin and hematocrit, hemolysis, lymphadenopathy, neutropenia, pancytopenia, thrombocytopenia

Hepatic

• Uncommon (0.1% to 1%): Hepatic failure, hepatitis either hepatocellular or cholestatic, jaundice
• Rare (0.01% to 0.1%): Hepatitis including necrosis, increased liver enzymes and/or serum bilirubin, cholestasis
• Frequency not reported: Fulminant hepatic necrosis

Hypersensitivity

• Common (1% to 10%): Angioneurotic edema, angioneurotic edema of the face, extremities, lips, tongue, glottis and/or larynx, rash
• Uncommon (0.1% to 1%): Photosensitivity, urticaria
• Frequency not reported: Anaphylactoid reactions, hypersensitivity reactions, intestinal angioedema

Angioedema associated with laryngeal edema may be fatal.

Immunologic

• Rare (0.01% to 0.1%): Autoimmune diseases

Metabolic

• Common (1% to 10%): Hyperkalemia
• Uncommon (0.1% to 1%): Anorexia, hypoglycemia, hyponatremia

Musculoskeletal

• Uncommon (0.1% to 1%): Muscle cramps
• Frequency not reported: Arthralgias or arthritis and myalgias or myositis, flank pain

Nervous system

• Very common (10% or more): Dizziness
• Common (1% to 10%): Headache, postural dizziness, syncope, taste alteration, vertigo
• Uncommon (0.1% to 1%): Cerebrovascular accident, insomnia, paresthesia, somnolence, tinnitus
• Frequency not reported: Anosmia, ataxia, peripheral neuropathy (dysesthesia)

Ocular

• Very common (10% or more): Blurred vision
• Frequency not reported: Conjunctivitis, dry eyes, tearing

Other

• Very common (10% or more): Asthenia
• Common (1% to 10%): Fatigue, orthostatic effects
• Uncommon (0.1% to 1%): Fever, increased blood urea nitrogen, malaise
• Frequency not reported: Death, elevated erythrocyte sedimentation rate, herpes zoster, positive ANA (Antinuclear antibody), serositis

Psychiatric

• Common (1% to 10%): Depression
• Uncommon (0.1% to 1%): Confusion, dream abnormality, nervousness
• Rare (0.01% to 0.1%): Sleep disorders

Renal

• Common (1% to 10%): Increased serum creatinine and potassium, microalbuminuria, urinary tract infection
• Uncommon (0.1% to 1%): Oliguria, proteinuria, renal failure, renal dysfunction

Respiratory

• Very common (10% or more): Cough
• Common (1% to 10%): Bronchitis, dyspnea, pneumonia
• Uncommon (0.1% to 1%): Asthma, bronchospasm, pulmonary infiltrates, rhinorrhea, sore throat and hoarseness
• Rare (0.01% to 0.1%): Allergic alveolitis, eosinophilic pneumonitis, rhinitis
• Frequency not reported: Pulmonary embolism and infarction, pulmonary edema, upper respiratory infection

See also:

Further information

Enalaprilat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer