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Enalaprilat Dosage

Medically reviewed by Drugs.com. Last updated on Jun 28, 2023.

Applies to the following strengths: 2.5 mg; 5 mg; 10 mg; 20 mg; 1.25 mg/mL; 1 mg/mL

Usual Adult Dose for Hypertension

Initial dose (oral tablets or solution): 5 mg orally once a day
Maintenance dose (oral tablets or solution): 10 to 40 mg orally per day as a single dose or in 2 divided doses
Maximum dose: 40 mg orally daily as a single dose or in 2 divided doses

In combination with diuretics:
Initial dose: 2.5 mg orally once a day
If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with enalapril. If required, diuretic therapy may be gradually resumed.

Parenteral: 1.25 to 5 mg IV over a 5 minute period every 6 hours

Comments:

Usual Adult Dose for Congestive Heart Failure

Initial dose: 2.5 mg orally once a day
Maintenance dose: 2.5 to 20 mg daily in 2 divided doses
Maximum dose: 40 mg orally per day in 2 divided doses

Comments:

Usual Adult Dose for Left Ventricular Dysfunction

Initial dose: 2.5 mg orally twice a day
Maintenance dose: 20 mg orally per day in 2 divided doses

Comments:

Usual Pediatric Dose for Hypertension

Oral tablets or solution:
Children 1 month to 17 years:
Initial dose: 0.08 mg/kg/day (up to 5 mg) in 1 to 2 divided doses. Adjust dosage based on patient response.
Maximum dose: Doses greater than 0.58 mg/kg (40 mg) have not been evaluated in pediatric patients.

Comment:

Renal Dose Adjustments

CrCl 30 mL/min or less:


There are no data on the safety and efficacy of enalapril in neonates and pediatric patients with CrCl of less than 30 mL/min.

Liver Dose Adjustments

Data not available

Dose Adjustments

Precautions

US BOXED WARNING:


IV solution: Safety and efficacy have not been established in patients younger than 18 years.
Oral solution: This drug is not recommended for use in neonates (1 month or younger), preterm infants less than 44 weeks (corrected post-conceptual age), or pediatric patients with CrCl less than 30 mL/min. Safety and efficacy have not been established in pediatric patients with heart failure or asymptomatic left ventricular dysfunction.
Oral tablet: This drug is not recommended for use in neonates or pediatric patients with CrCl less than 30 mL/min.

Consult WARNINGS section for dosing related precautions.

Dialysis

Enalapril is removed by hemodialysis (20% to 50%)
Hemodialysis: 2.5 mg on dialysis days; oral solution: Use a lower initial dose.
The dosage on nondialysis days should be adjusted according to blood pressure response.

Other Comments

Administration Advice:


General:

Monitoring:

Patient advice:

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