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Eletriptan Side Effects

In Summary

Commonly reported side effects of eletriptan include: weakness. Other side effects include: drowsiness, chest pain, paresthesia, nausea, chest tightness, chest pressure, and dizziness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eletriptan: oral tablet

In addition to its needed effects, some unwanted effects may be caused by eletriptan. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking eletriptan:

Less common:
  • Chest pain or tightness
  • difficulty with swallowing
  • tightness in the throat
Rare
  • Chest discomfort
  • dizziness
  • headache
  • nausea
  • nosebleeds
  • numbness or tingling in the face, arms or legs
  • pain or discomfort in the arms, jaw, back or neck
  • sweating
  • vision problems
  • vomiting
Incidence not known:
  • Abdominal or stomach pain
  • agitation
  • bloody diarrhea
  • confusion
  • cough
  • diarrhea
  • difficulty in speaking
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever
  • inability to move arms, legs, or facial muscles
  • overactive reflexes
  • pain in the arms legs, or lower back, especially pain in calves or heels upon exertion
  • pale, bluish-colored, or cold hands or feet
  • paleness or cold feeling in fingertips and toes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • seizures
  • severe or sudden headache
  • shivering
  • skin rash, hives, or itching
  • slurred speech
  • sudden loss of coordination
  • sweating
  • talking or acting with excitement you cannot control
  • tingling or pain in the fingers or toes when exposed to cold
  • trembling or shaking
  • twitching
  • unusual tiredness or weakness
  • weak or absent pulses in the legs
  • weakness in the arm or leg on one side of the body, sudden and severe

Minor Side Effects

Some of the side effects that can occur with eletriptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Lack or loss of strength
  • sleepiness or unusual drowsiness
Less common:
  • Acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • dry mouth
  • heartburn
  • indigestion
  • stomach soreness or discomfort
  • stomach upset

For Healthcare Professionals

Applies to eletriptan: oral tablet

General

The most commonly reported adverse events have included asthenia, nausea, dizziness, and somnolence.[Ref]

Cardiovascular

Transient, dose-related increases in blood pressure (BP) have been observed, particularly in the elderly and among patients with renal impairment, and predominantly increases to diastolic BP. One patients with hepatic cirrhosis experienced a BP of 220/96 mmHg 5 hours after a receiving an 80 mg dose.[Ref]

Common (1% to 10%): Chest tightness/pain/pressure, palpitation
Uncommon (0.1% to 1%): Hypertension, peripheral vascular disorder, tachycardia
Rare (0.01% to 0.1%): Angina pectoris, arrhythmia, atrial fibrillation, AV block, bradycardia, hypotension, syncope, thrombophlebitis, vasospasm, shock
Very rare (less than 0.01%): Acute myocardial infarction, ventricular tachycardia, ventricular fibrillation, coronary artery vasospasm, transient myocardial ischemia
Frequency not reported: Edema[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain/discomfort/stomach pain/cramps/pressure, dry mouth, dyspepsia, nausea
Uncommon (0.1% to 1%): Dysphagia, throat tightness/difficulty swallowing, anorexia, constipation, diarrhea, eructation, esophagitis, flatulence, gastritis, gastrointestinal disorder, glossitis, increased salivation
Rare (0.01% to 0.1%): Enlarged abdomen, halitosis, gingivitis, hematemesis, stomatitis, tongue disorder, tongue edema, tooth disorder
Postmarketing reports: Ischemic colitis, vomiting[Ref]

Nervous system

Common (1% to 10%): Paresthesia, dizziness, somnolence, headache, hypertonia, hyperesthesia, myasthenia
Uncommon (0.1% to 1%): Ataxia, incoordination, speech disorder, stupor, tremor, taste perversion
Rare (0.01% to 0.1%): Abnormal gait, aphasia, dystonia, hemiplegia, hyperalgesia, hypokinesia, neuropathy, paralysis, twitching, parosmia
Frequency not reported: Serotonin syndrome
Postmarketing reports: Seizure, cerebrovascular accident[Ref]

Hypersensitivity

Postmarketing reports: Allergic reactions including angioedema[Ref]

Endocrine

Rare (0.01% to 0.1%): Goiter, thyroid adenoma, thyroiditis, breast pain[Ref]

Hematologic

Rare (0.01% to 0.1%): Anemia, leukopenia, purpura, lymphadenopathy[Ref]

Metabolic

Uncommon (0.1% to 1%): Thirst
Rare (0.01% to 0.1%): Increased appetite, weight gain, weight loss[Ref]

Musculoskeletal

Common (1% to 10%): Back pain[Ref]

Respiratory

Common (1% to 10%): Pharyngitis, throat tightness
Uncommon (0.1% to 1%): Asthma, dyspnea, respiratory disorder, respiratory tract infection, rhinitis, voice alteration, yawn
Rare (0.01% to 0.1%): Bronchitis, choking sensation, increased cough, epistaxis, hyperventilation, laryngitis, sinusitis, increased sputum[Ref]

Dermatologic

Common (1% to 10%): Sweating
Uncommon (0.1% to 1%): Face edema, pruritus, rash, skin disorder
Rare (0.01% to 0.1%): Alopecia, dry skin, eczema, exfoliative dermatitis, maculopapular rash, psoriasis, skin discoloration, skin hypertrophy, urticaria[Ref]

Ocular

Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, eye pain, lacrimation disorder, photophobia
Rare (0.01% to 0.1%): Oculogyric crisis, dry eyes, eye hemorrhage, ptosis, diplopia, abnormality of accommodation[Ref]

Other

Common (1% to 10%): Asthenia, flushing/feeling of warmth, chills, malaise, vertigo
Uncommon (0.1% to 1%): Ear pain, tinnitus
Rare (0.01% to 0.1%): Fever, hypothermia, otitis media[Ref]

Genitourinary

Uncommon (0.1% to 1%): Impotence, polyuria, urinary frequency, urinary tract disorder
Rare (0.01% to 0.1%): Menstrual disorder, menorrhagia, vaginitis[Ref]

Psychiatric

Uncommon (0.1% to 1%): Abnormal dreams, agitation, anxiety, apathy, depersonalization, depression, emotional lability euphoria, insomnia, nervousness
Rare (0.01% to 0.1%): Amnesia, catatonic reaction, hallucinations, manic reaction, hysteria, neurosis, psychotic depression, sleep disorder[Ref]

References

1. "Product Information. Relpax (eletriptan)." Pfizer U.S. Pharmaceuticals, New York, NY.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for eletriptan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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