Efudex Occlusion Pack Side Effects

Generic name: fluorouracil topical

Medically reviewed by Drugs.com. Last updated on Sep 7, 2023.

Note: This document provides detailed information about Efudex Occlusion Pack Side Effects associated with fluorouracil topical. Some dosage forms listed on this page may not apply specifically to the brand name Efudex Occlusion Pack.

Applies to fluorouracil topical: topical cream, topical solution.

Precautions

It is very important that your doctor check your progress at regular visits for any unwanted effects that may be caused by this medicine.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds. If you have a severe reaction from the sun, check with your doctor.

This medicine may cause black, tarry stools, blurred or double vision, chills, cough, diarrhea, difficulty in walking, drooping eyelids, fever, headache, jaw pain, lower back or side pain, numbness or tingling in the fingers and toes, pain in the fingers, toes, and testicles, painful or difficult urination, pale skin, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swelling or inflammation of the mouth, unusual bleeding or bruising, or unusual tiredness or weakness. Check with your doctor right away if you notice any of these serious side effects.

Serious side effects

Along with its needed effects, fluorouracil topical (the active ingredient contained in Efudex Occlusion Pack) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluorouracil topical:

Other side effects

Some side effects of fluorouracil topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

See also:

For healthcare professionals

Applies to fluorouracil topical: topical cream, topical kit, topical solution.

Dermatologic adverse events

• Very rare (less than 0.01%): Pruritus, urticaria, rash (local or generalized), erythema (i.e., erythema multiforme), burning sensation, exfoliation, swelling, ulceration, allergic contact dermatitis, eczema, blistering, alopecia, pain
• Frequency not reported: Hyperpigmentation, crusting, irritation, photosensitivity, scarring, bullous pemphigoid, ichthyosis, scaling, suppuration, telangiectasia, tenderness, herpes simplex^[Ref]

Gastrointestinal

• Very rare (less than 0.01%): Diarrhea, vomiting, abdominal pain, stomatitis, mucosal inflammation
• Frequency not reported: Nausea, medicinal taste^[Ref]

Hematologic

• Frequency not reported: Leukocytosis, eosinophilia, thrombocytopenia, toxic granulation^[Ref]

Hypersensitivity

• Very rare (less than 0.01%): Hypersensitivity^[Ref]

Nervous system

• Frequency not reported: Dysgeusia, headache, dizziness^[Ref]

Ocular

• Frequency not reported: Conjunctival irritation, corneal reaction, keratitis, increased lacrimation^[Ref]

Other

• Very rare (less than 0.01%): Pyrexia, chills^[Ref]

Respiratory

• Frequency not reported: Nasal irritation^[Ref]

Psychiatric

• Frequency not reported: Emotional upset, irritability, insomnia^[Ref]

Further information

Efudex Occlusion Pack side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer