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Doxylamine / pyridoxine Side Effects

In Summary

Commonly reported side effects of doxylamine/pyridoxine include: drowsiness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to doxylamine / pyridoxine: oral tablet delayed release, oral tablet extended release

Along with its needed effects, doxylamine/pyridoxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking doxylamine / pyridoxine:

Incidence not known
  • Chest discomfort
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or labored breathing
  • difficult or painful urination
  • fast, irregular, pounding, or racing heartbeat or pulse
  • swelling of the eyelids, face, lips, hands, or feet

Some side effects of doxylamine / pyridoxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Unusual drowsiness

For Healthcare Professionals

Applies to doxylamine / pyridoxine: oral delayed release tablet


Postmarketing reports: Palpitation, tachycardia[Ref]


Postmarketing reports: Hyperhidrosis, pruritus, rash, maculo-papular rash[Ref]


Postmarketing reports: Abdominal distension, abdominal pain, constipation, diarrhea[Ref]


Postmarketing reports: Hypersensitivity[Ref]

Nervous system

Very common (10% or more): Somnolence (14.3%)
Postmarketing reports: Vertigo, dizziness, headache, migraines, paresthesia, psychomotor hyperactivity[Ref]


Postmarketing reports: Blurred vision, visual disturbances[Ref]


Postmarketing reports: Chest discomfort, fatigue, irritability, malaise[Ref]


Postmarketing reports: Anxiety, disorientation, insomnia, nightmares[Ref]


Postmarketing reports: Dysuria, urinary retention[Ref]


Postmarketing reports: Dyspnea[Ref]


1. "Product Information. Diclegis (doxylamine-pyridoxine)." Duchesnay USA Inc, Rosemont, PA.

Some side effects of doxylamine / pyridoxine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.