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Diprivan Side Effects

Generic Name: propofol

Note: This document contains side effect information about propofol. Some of the dosage forms listed on this page may not apply to the brand name Diprivan.

For the Consumer

Applies to propofol: parenteral injectable emulsion

Side effects include:

Use for anesthesia or MAC sedation: Bradycardia, arrhythmia, tachycardia, hypotension, hypertension, movement, burning/stinging, pain at injection site, apnea, rash, pruritus.

Use for critical care setting sedation: Bradycardia, decreased cardiac output, hypotension, hyperlipidemia, respiratory acidosis (during weaning).

For Healthcare Professionals

Applies to propofol: intravenous emulsion

Cardiovascular

Very common (10% or more): Hypotension (up to 75%)

Common (1% to 10%): Hypertension, bradycardia

Uncommon (0.1% to 1%): Arrhythmias, tachycardia, extrasystole

Rare (0.01% to 0.1%): Pulmonary edema, asystole, syncope, perioperative arrhythmias, cardiac arrest

Very rare (less than 0.01%): Cardiac failure, pulmonary edema

Frequency not reported: Cardiac arrhythmia[Ref]

Dermatologic

Very common (10% or more): Pruritus (up to 28%)

Common (1% to 10%): Transient flush, rash[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting

Very rare (less than 0.01%): Pancreatitis, abdominal cramps[Ref]

Genitourinary

Rare (Less than 0.1%): Discoloration of the urine following prolonged use[Ref]

Hepatic

Frequency not reported: Hepatomegaly[Ref]

Hypersensitivity

Rare (0.01% to 0.1%): Anaphylaxis, in some cases with angioedema, bronchospasm, erythema, and hypotension (these reactions have been reported to respond to adrenaline)[Ref]

Local

Common (1% to 10%): Pain during injection (burning, tingling/slinging)

Very rare (less than 0.01%): Tissue necrosis following accidental extravascular administration[Ref]

Metabolic

Very rare (less than 0.01%): Metabolic acidosis, hyperkalemia, hyperlipidemia[Ref]

Musculoskeletal

Very rare (less than 0.01%): Rhabdomyolysis (when administered at doses greater than 4 mg/kg/hour for ICU sedation)[Ref]

Nervous system

Very common (10% or more): Paresthesia (up to 74%), excitation phenomena such as involuntary movements, twitches, tremors, hypertonus, hiccup

Common (1% to 10%): Headache, shivering

Rare (0.01% to 0.1%): Convulsions and seizures of the epileptic type

Very rare (less than 0.01%): Postoperative unconsciousness

Frequency not reported: Involuntary movements[Ref]

Paresthesias (including burning, tingling, stinging) and/or pruritus, usually manifested in the perineal region, were the most frequently recorded adverse reactions in clinical trials. Paresthesias and pruritus generally occurred within 5 minutes after administration of the initial dose and were generally transient and mild to moderate in intensity. The pharmacologic basis of these sensory phenomena is unknown. No pretreatments, including the use of nonsteroidal anti-inflammatory drugs, opioids, or lidocaine, are known to have an effect on or to reduce the incidence of these sensations.[Ref]

Respiratory

Very common (10% or more): Hypoxemia (up to 11%)

Common (1% to 10%): Procedural pain (bronchoscopy), transient apnea, cough

Very rare (less than 0.01%): Pulmonary edema, hiccough[Ref]

Renal

Very rare (less than 0.01%): Renal failure[Ref]

Hematologic

Common (1% to 10%): Thrombosis, phlebitis[Ref]

References

1. "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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