Diclofenac / menthol topical Side Effects
For the Consumer
Diclofenac and menthol can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Diclofenac and menthol may also cause stomach or intestinal bleeding, which can be fatal.
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Stop using this medicine and seek emergency medical attention if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Also call your doctor at once if you have:
a skin rash, no matter how mild;
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.
Serious side effects may be more likely in older adults.
Common side effects may include:
skin dryness, redness, itching, or rash;
blistering or hardening of the treated skin;
numbness, tingling, burning pain;
flushing (sudden warmth, redness, or tingly feeling);
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to diclofenac / menthol topical: topical liquid
The most common adverse events reported with diclofenac sodium topical solution were application site skin reactions.[Ref]
Very common (10% or more): Dry skin (32%)
Application site reactions were reported as dryness, erythema, induration, vesicles, paresthesia, pruritus, vasodilation, acne, and urticaria.
Common (1% to 10%): Ecchymosis
Postmarketing reports: Rectal hemorrhage
Postmarketing reports: Allergic reaction
Common (1% to 10%): Pharyngitis, sinusitis
Postmarketing reports: Back pain, leg cramps, myalgia
Postmarketing reports: Increased creatinine
Common (1% to 10%): Rash (non-application site), dry skin (non-application site)
Postmarketing reports: Depression
Postmarketing reports: Asthenia, body odor, pain
Common (1% to 10%): Paresthesia
Common (1% to 10%): Edema
Postmarketing reports: Chest pain, palpitation, cardiovascular disorder
More about diclofenac / menthol topical
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: topical non-steroidal anti-inflammatories
- Other brands
Related treatment guides
1. "Product Information. DicloStream (diclofenac-menthol topical)." UpStream Pharma LLC, Biloxi, MS.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.