Dextromethorphan / Pseudoephedrine / Triprolidine Side Effects

Applies to dextromethorphan / pseudoephedrine / triprolidine: oral liquid.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• dizziness;

• nervousness; or

• sleep problems (insomnia).

Common side effects may include:

• drowsiness; or

• feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

See also:

For healthcare professionals

Applies to dextromethorphan/pseudoephedrine/triprolidine: oral liquid.

Cardiovascular adverse events

• Rare (0.01% to 0.1%): Palpitations, hypotension
• Frequency not reported: Dysrhythmias, myocardial infarction/myocardial ischemia, tachycardia, hypertension^[Ref]

Dermatologic

• Frequency not reported: Angioedema, pruritus, rash, severe skin reaction, acute generalized exanthematous pustulosis (AGEP), urticaria^[Ref]

Gastrointestinal

• Common (1% to 10%): Dry mouth, gastrointestinal disorder, nausea
• Frequency not reported: Abdominal pain, diarrhea, ischemic colitis, vomiting^[Ref]

Genitourinary

• Common (1% to 10%): Urinary retention
• Frequency not reported: Dysuria^[Ref]

Hematologic

• Rare (0.01% to 0.1%): Blood disorder^[Ref]

Hepatic

• Rare (0.01% to 0.1%): Liver disorder^[Ref]

Hypersensitivity

• Rare (0.01% to 0.1%): Cross-sensitivity with other sympathomimetics^[Ref]

Nervous system

• Very common (10% or more): Headache
• Common (1% to 10%): Dizziness, paradoxical stimulation, psychomotor impairment, somnolence
• Rare (0.01% to 0.1%): Extrapyramidal disorder, seizure, tremor
• Frequency not reported: Cerebrovascular accident, paresthesia, posterior reversible encephalopathy syndrome (PRES), reversible cerebral vasoconstriction syndrome (RCVS), psychomotor hyperactivity^[Ref]

Ocular

• Common (1% to 10%): Vision blurred^[Ref]

Other

• Frequency not reported: Drug withdrawal syndrome, fatigue^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, nervousness
• Rare (0.01% to 0.1%): Confusion, depression, sleep disorder
• Frequency not reported: Anxiety, drug dependence, euphoric mood, excitability, hallucinations, irritability, paranoid delusions, restlessness^[Ref]

Respiratory

• Common (1% to 10%): Increased viscosity of bronchial secretion
• Frequency not reported: Dry throat, epistaxis, nasal dryness, respiratory depression^[Ref]

Further information

Dextromethorphan/pseudoephedrine/triprolidine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer