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Dasatinib Side Effects

In Summary

Commonly reported side effects of dasatinib include: pericardial effusion, pleural effusion, pulmonary edema, dyspnea, fluid retention, and gastrointestinal hemorrhage. Other side effects include: anasarca. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dasatinib: oral tablet

Along with its needed effects, dasatinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dasatinib:

More common
  • Bloody or black, tarry stools
  • body aches or pain
  • burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  • chest pain
  • chills
  • constipation
  • cough
  • coughing up blood
  • decrease in the amount of urine
  • dizziness
  • ear congestion
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • full or bloated feeling
  • headache
  • hoarseness
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • noisy or rattling breathing
  • painful or difficult urination
  • pale skin
  • paralysis
  • pressure in the stomach
  • runny nose
  • sensation of pins and needles
  • severe stomach pain
  • sneezing
  • sore throat
  • stabbing pain
  • swelling of the abdominal or stomach area
  • swelling of the face, fingers, hands, feet, or lower legs
  • tightness in the chest
  • troubled breathing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weakness in the arms, hands, legs, or feet
  • weight gain
Less common
  • Blue lips and fingernails
  • chest discomfort
  • coughing that sometimes produces a pink frothy sputum
  • decreased urine output
  • difficult or fast breathing
  • dilated neck veins
  • increased sweating
  • irregular breathing
  • nausea
  • swelling in the legs and ankles
Incidence not known
  • Anxiety
  • pain, redness, or swelling in the arm or leg
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area

Some side effects of dasatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bleeding gums
  • cracked lips
  • diarrhea
  • difficulty with moving
  • difficulty with swallowing
  • increased menstrual flow or vaginal bleeding
  • itching skin or rash
  • lack or loss of strength
  • loss of appetite
  • muscle aching, cramping, or stiffness
  • muscle or bone pain
  • nose bleeds
  • pain
  • pain in the joints
  • prolonged bleeding from cuts
  • red or dark brown urine
  • stomach pain
  • swollen joints
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to dasatinib: oral tablet


In the phase III dose optimization study in patients with chronic phase CML, grade 3 or 4 myelosuppression occurred more frequently in patients treated with the 70 mg twice daily regimen than in those treated with a 100 mg once daily regimen.[Ref]

Very common (10% or more): Hemorrhage (11 to 26%)
Common (1% to 10%): Febrile neutropenia, pancytopenia
Uncommon (0.1% to 1%): CNS bleeding
Rare (Less than 0.1%): Aplasia pure red cell[Ref]


The most common side effects included fluid retention, musculoskeletal pain, diarrhea, rash, and headache.[Ref]


Very common (10% or more): Diarrhea (18 to 31%), vomiting (11 to 16%), nausea (18 to 24%), abdominal pain (12%)
Common (1% to 10%): Enterocolitis infection, gastrointestinal bleeding, neutropenic colitis, gastritis, mucositis, stomatitis, dyspepsia, abdominal distension, constipation, oral soft tissue disorder
Uncommon (0.1% to 1%): Pancreatitis, upper gastrointestinal ulcer, esophagitis, ascites, anal fissure, dysphagia
Rare (Less than 0.1%): Protein-losing gastroenteropathy, ileus
Postmarketing reports: Fatal gastrointestinal hemorrhage[Ref]

Nervous system

Very common (10% or more): Headache (13 to 33%)
Common (1% to 10%): Neuropathy, peripheral neuropathy, dizziness, dysgeusia, somnolence
Uncommon (0.1% to 1%): Syncope, amnesia, tremor
Rare (Less than 0.1%): Cerebrovascular accident, transient ischemic attack, convulsion, optic neuritis, seventh nerve paralysis[Ref]


Very common (10% or more): Musculoskeletal pain (11 to 22%)
Common (1% to 10%): Arthralgia, myalgia, muscular weakness, musculoskeletal stiffness, muscle spasm, chills
Uncommon (0.1% to 1%): Rhabdomyolysis, muscle inflammation, tendonitis, blood creatine phosphokinase increased[Ref]


Very common (10% or more): Pleural effusion (11 to 24%), dyspnea (15 to 24%), cough
Common (1% to 10%): Pneumonia (including bacterial, viral, fungal), upper respiratory tract infection, pulmonary edema, pulmonary hypertension, lung infiltration, pneumonitis
Uncommon (0.1% to 1%): Bronchospasm, asthma
Rare (Less than 0.1%): Acute respiratory distress syndrome
Postmarketing reports: Pulmonary embolism, interstitial lung disease, pulmonary arterial hypertension[Ref]


Common (1% to 10%): Anorexia, appetite disturbances, hyperuricemia, weight decreased, weight increased
Uncommon (0.1% to 1%): Hypoalbuminemia[Ref]


Uncommon (0.1% to 1%): Hepatitis, cholecystitis, cholestasis[Ref]


Common (1% to 10%): Congestive heart failure, cardiac dysfunction, pericardial effusion, arrhythmia, tachycardia, palpitations, hypertension, chest pain
Uncommon (0.1% to 1%): Myocardial infarction, electrocardiogram QT prolongation, pericarditis, ventricular arrhythmia, ventricular tachycardia, angina pectoris, cardiomegaly, hypotension
Rare (less than 0.1%): Cor pulmonale, myocarditis, acute coronary syndrome
Postmarketing reports: Atrial fibrillation, atrial flutter[Ref]

Results from phase II single arm clinical studies of 911 patients reported QT prolongation in 9 patients. Three patients (less than 1%) experienced a QTcF greater than 500 milliseconds.

In the phase III dose optimization study in patients with chronic phase CML, pleural effusion and congestive cardiac failure/cardiac dysfunction occurred more frequently in the 70 mg twice a day regimen than in those treated with a 100 mg once daily regimen.[Ref]


Very common (10% or more): Skin rash (15 to 21%)
Common (1% to 10%): Flushing, alopecia, dermatitis, eczema, pruritus, acne, dry skin, urticaria, hyperhidrosis, contusion
Uncommon (0.1% to 1%): Acute febrile neutrophilic dermatosis, photosensitivity, pigmentation disorder, panniculitis, skin ulcer, bullous conditions, nail disorder, palmar-plantar erythrodysesthesia syndrome
Rare (Less than 0.1%): Livedo reticularis[Ref]


Very common (10% or more): Fluid retention (21 to 42%)
Uncommon (0.1% to 1%): Renal failure, urinary frequency, proteinuria[Ref]


Very common (10% or more): Fatigue (19 to 26%), superficial edema (10 to 21%), pyrexia (11 to 18%)
Common (1% to 10%): Tinnitus, pain, generalized edema, asthenia
Uncommon (0.1% to 10%): Vertigo, thrombophlebitis, gynecomastia, irregular menstruation, malaise, temperature intolerance
Postmarketing reports: Deep vein thrombosis[Ref]


Common (1% to 10%): Depression, insomnia
Uncommon (0.1% to 1%): Anxiety, confusion, affect lability, libido decreased[Ref]


Uncommon (0.1% to 1%): Erythema nodosum, unspecified hypersensitivity reaction[Ref]


Common (1% to 10%): Visual disturbance, blurred vision, reduction in visual acuity, dry eye
Uncommon (0.1% to 1%): Conjunctivitis
Rare (Less than 0.1%): Visual impairment[Ref]


Uncommon (0.1% to 1%): Tumor lysis syndrome[Ref]


Very common (10% or more): Infection (including bacterial, viral, fungal, non-specified) (10 to 14%)
Common (1% to 10%): Sepsis[Ref]


1. "Product Information. Sprycel (dasatinib)." Bristol-Myers Squibb, Princeton, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.