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Combivent Respimat Side Effects

Generic name: albuterol / ipratropium

Medically reviewed by Drugs.com. Last updated on Mar 9, 2024.

Note: This document contains side effect information about albuterol / ipratropium. Some dosage forms listed on this page may not apply to the brand name Combivent Respimat.

Applies to albuterol / ipratropium: inhalation solution, inhalation spray.

Serious side effects of Combivent Respimat

Along with its needed effects, albuterol/ipratropium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking albuterol / ipratropium:

More common

Less common

Rare

Incidence not known

Other side effects of Combivent Respimat

Some side effects of albuterol / ipratropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to albuterol / ipratropium: inhalation aerosol, inhalation solution.

Respiratory

Common (1% to 10%): Cough, dyspnea, bronchitis, nasopharyngitis, upper respiratory infection, pharyngolaryngeal pain, wheezing, respiratory disorder, sinusitis, bronchospasm, dysphonia, increased sputum

Rare (less than 0.1%): Laryngospasm

Postmarketing reports: Throat irritation, paradoxical bronchospasm, nasal congestion, pharyngeal edema[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, tremor, nervousness, insomnia

Postmarketing reports: Central nervous system stimulation, mental disorder[Ref]

Other

Common (1% to 10%): Asthenia, influenza -like illness, chest discomfort[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, palpitations, tachycardia, arrhythmia, angina, systolic blood pressured increased

Rare (less than 0.1%): Diastolic blood pressure decreased

Postmarketing reports: Myocardial ischemia, supraventricular tachycardia and/or atrial fibrillation[Ref]

Hypersensitivity

Postmarketing reports: Rash, pruritus, and urticaria (including giant urticaria), angioedema including that of tongue, lips and face, laryngospasm, and anaphylactic reaction[Ref]

Ocular

Common (1% to 10%): Eye pain

Postmarketing reports: Glaucoma, blurred vision, mydriasis, conjunctival hyperemia, halo vision, accommodation disorder, ocular irritation, corneal edema, intraocular pressure increased[Ref]

There are numerous case reports in the literature of precipitation of glaucoma with the use of ipratropium and albuterol via nebulized solution. This is thought to occur through direct contact with the eyes, and is seen with the combination since both beta agonists and anticholinergics can increase intraocular pressure. There is one report of glaucoma associated with the use of nebulized albuterol and ipratropium aerosol in an emergency department. Caution is warranted when the combination is used in patients predisposed to glaucoma. Extra care should be taken to avoid contact with the eyes.[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, dry mouth, constipation, vomiting, dyspepsia, taste perversion, dry throat

Postmarketing reports: Gastrointestinal motility disorder (e.g., diarrhea), drying of secretions, stomatitis, mouth edema[Ref]

Musculoskeletal

Common (1% to 10%): Muscle spasms, myalgia, arthralgia

Postmarketing reports: Muscular weakness[Ref]

Metabolic

Common (1% to 10%): Hypokalemia

Frequency not reported: Lactic acidosis[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash

Postmarketing reports: Angioedema, hyperhidrosis, skin reaction[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, dysuria

Postmarketing reports: Urinary retention[Ref]

References

1. (2001) "Product Information. Combivent (albuterol-ipratropium)." Boehringer-Ingelheim

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.