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Colcrys Side Effects

Generic name: colchicine

Medically reviewed by Last updated on Oct 19, 2023.

Note: This document contains side effect information about colchicine. Some dosage forms listed on this page may not apply to the brand name Colcrys.

Applies to colchicine: oral capsule, oral solution, oral tablet.

Serious side effects of Colcrys

Along with its needed effects, colchicine (the active ingredient contained in Colcrys) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking colchicine:

More common


Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking colchicine:

Symptoms of overdose

Other side effects of Colcrys

Some side effects of colchicine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to colchicine: compounding powder, intravenous solution, oral capsule, oral liquid, oral tablet.


The most common adverse reactions have included gastrointestinal symptoms and pharyngolaryngeal pain.[Ref]


Very common (10% or more): Diarrhea (23%)

Common (1% to 10%): Abdominal cramping, abdominal pain, nausea, vomiting

Frequency not reported: Lactose intolerance, gastrointestinal hemorrhage, paralytic ileus, stomatitis[Ref]

Gastrointestinal events including diarrhea, nausea, vomiting, and abdominal pain are the most common adverse reactions reported with use of this drug. These events are often the first signs of toxicity and may indicate the need for dose reduction or therapy discontinuation.[Ref]


Rare (less than 0.1%): Agranulocytosis, thrombocytopenia, aplastic anemia

Postmarketing reports: Myelosuppression, disseminated intravascular coagulation[Ref]

Nervous system

Rare (less than 0.1%): Peripheral neuritis

Frequency not reported: Sensory motor neuropathy[Ref]


Rare (less than 0.1%): Myopathy, rhabdomyolysis

Frequency not reported: Elevated CPK, myotonia, muscle weakness, muscle pain[Ref]


Very rare (less than 0.01%): Hypersensitivity including angioedema[Ref]


Frequency not reported: Renal damage, bladder spasm, anuria, oliguria[Ref]


Frequency not reported: elevated AST, elevated ALT, elevated alkaline phosphatase, hepatic damage[Ref]


Common (1% to 10%): Pharyngolaryngeal pain

Postmarketing reports: Adult respiratory distress syndrome[Ref]


Frequency not reported: Delayed corneal wound healing[Ref]

There have been reports of corneal ulcers refractory to conventional treatment and delayed corneal wound healing following strabismus surgery in patients receiving colchicine. Discontinuation of colchicine therapy resulted in satisfactory wound healing within several days.[Ref]


Rare (less than 0.1%): Alopecia

Very rare (less than 0.01%): Nonthrombocytopenic purpura rashes, rashes, urticaria, dermatoses, dermatitis

Frequency not reported: Maculopapular rash[Ref]


Frequency not reported: Hypothyroidism[Ref]


Rare (less than 0.1%): Azoospermia, oligospermia

Frequency not reported: Amenorrhea, dysmenorrhea, hematuria[Ref]


Frequency not reported: Loss of appetite[Ref]

Frequently asked questions


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Colcrys (colchicine). AR Scientific Inc. 2009.

4. Product Information. Mitigare (colchicine). Hikma Americas, Inc. 2016.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.